Lipoproteins and Atherosclerosis

1. Front Matter

   Pages i-x

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2. Chemistry of Plasma Lipoproteins

   1. Heterogeneity of Apolipoprotein B Containing Lipoproteins

      • Ross W. Milne, Philip K. Weech, Yves L. Marcel

      Pages 1-5

   2. Separation and Identification of APO-B-Containing Lipoprotein Particles in Normolipidemic Subjects and Patients with Hyperlipoproteinemias

      • Petar Alaupovic, Marcelo Tavella, James Fesmire

      Pages 7-14

   3. HDL Subfractions, HDL Receptors and HDL Turnover

      • A. van Tol, F. M. van’t Hooft, T. van Gent, G. M. Dallinga-Thie

      Pages 15-21

   4. Use of Monoclonal Antibodies to Human Apo A–I in the Determination of Antigenic Sites Present on HDL Surface

      • M. Ayrault-Jarrier, E. Petit, E. D. Bekaert, D. Pastier, H. Robin, J. Polonovski et al.

      Pages 23-30

   5. Epitope Expression in Purified and Lipid-Bound forms of Human Apoprotein A–I

      • Richard W. James, Daniel Pometta

      Pages 31-35

   6. Apolipoprotein D, Monoclonal Antibodies, and Cross-Reacting Proteins

      • Philip K. Weech, Rino Camato, Ross W. Milne, Yves L. Marcel

      Pages 37-40

   7. Characterisation and Mode of Inheritance of Apolipoprotein E3-Leiden

      • Louis Havekes, Gerd Utermann, Peter de Knijff, Eduard Klasen

      Pages 41-45

   8. Results of the Study of Apolipoprotein E and its Isomorphs on Isoelectric Focusing in Dyslipoproteinemias

      • E. Bruckert, F. Dairou, J. L. de Gennes, J. Truffert, G. Luc

      Pages 47-53

   9. Ag System Re-Explored: Studies with Monoclonal Anti-Apolipoprotein B Antibodies

      • Matti J. Tikkanen

      Pages 55-62

   10. Use of Combined Monoclonal Antibodies for the Immunochemical Determination of Apolipoproteins A–I and B in Human Plasma

       • Santica Marcovina, Alberico L. Catapano

       Pages 63-71

3. Metabolism of Plasma Lipoproteins

   1. Mechanism of Action of Lipoprotein Lipase and Hepatic Triglyceride Lipase

      • Richard L. Jackson, Larry R. McLean, Elvira Ponce, Ann Rechtin, Rudy A. Demel

      Pages 73-77

   2. The Role of LCAT and Cholesteryl Ester Transfer Proteins for the HDL and LDL Structure and Metabolism

      • Gerhard M. Kostner, Gabriele Knipping, Johanna E. M. Groener, Rudolf Zechner, Hans Dieplinger

      Pages 79-86

   3. Cholesteryl Ester Transfer in Atherosclerosis

      • Francis Heller, Pierre Mailleux, Michel Rousseau, Jean Etienne, Carl Harvengt

      Pages 87-93

   4. Metabolism of Apolipoprotein C: Kinetic Studies in Human Subjects: A Critical Review

      • Claude L. Malmendier, Jean-François Lontie, Ghislaine Grutman, Claude Delcroix

      Pages 95-103

   5. Turnover and Interconversion of LDL Sub-Fractions

      • G. R. Thompson, M. Kano, J. Reeve

      Pages 105-109

   6. Metabolic Determinants of Plasma High-Density Lipoprotein Concentration in Humans

      • Norman E. Miller

      Pages 111-115

   7. Lipid Metabolism and the Enterohepatic Circulation: The Regulatory Functions of HMG CoA Reductase and Cholesterol 7∝ Hydroxylase

      • James Shepherd, Christopher J. Packard

      Pages 117-122

   8. The Role of the LDL Receptor in Lipoprotein Metabolism

      • David W. Bilheimer, Scott M. Grundy

      Pages 123-130

   9. The Uptake of Chylomicron Remnants by the Liver

      • Eberhard E. T. Windier

      Pages 131-135

Atherosclerosis which accounts in Western Europe for more than 40 % of deaths, is a generalized disease that develops slowly and is symptomless until lesions have become sufficiently severe to cause myocardial or cerebral infarction. Research on specific and precocious markers of atherosclerosis and the development of non invasive techniques for their early detection represent major challenges in biomedical field. We hope that this volume of edited papers, a consequence of the third international colloquium on atherosclerosis, conducted at the University of Brussels, Belgium through the support of the "Fondation de Recherche sur l' AtherosclE,rose" will contribute to this goal. Among the topics discussed the major ones were the mechanism of action of lipolytic enzymes, the deficiency or dysregulation of cellular receptors, the genetic deficiencies of apolipoproteins, and the panoply of external factors as diet, physical exercise, drugs, which mOdify the lipoprotein metabolism. Special interest was also devoted to potent techniques as kinetic analysis of metabolic tracers and use of monoclonal antibodies. Their contribution to the detection and treatment of atherosclerosis will be obviously essential in the future.

• enzymes
• metabolism
• protein
• proteins
• receptor

• Research Unit on Atherosclerosis, The Free University of Brussels, Brussels, Belgium

  C. L. Malmendier

• Lipoprotein and Atherosclerosis Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA

  P. Alaupovic

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