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Lipoprotein Deficiency Syndromes

  • Book
  • © 1986

Overview

Editors:
  1. Aubie Angel

    1. Institute of Medical Sciences, University of Toronto, Toronto, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Jiri Frohlich

    1. Shaughnessy Hospital, University of British Columbia, Vancouver, Canada

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 201)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Lipoprotein Deficiency and Atherosclerosis

    1. Genetic High Density Lipoprotein Deficiency States and Atherosclerosis

      • Ernst J. Schaefer, Judith R. McNamara, Carol J. Mitri, Jose M. Ordovas
      Pages 1-15

    2. Metabolic Interrelationships of HDL Subclasses

      • Ronald M. Krauss, Alex V. Nichols
      Pages 17-27

    3. Speciation of HDL

      • John P. Kane
      Pages 29-35

    4. Modifications and Degradation of High Density Lipoproteins

      • A. Angel, B. Fong
      Pages 37-49

    5. Effect of Diabetes Mellitus and End-Stage Renal Disease on HDL Metabolism

      • M. H. Tan
      Pages 51-59

    6. HDL Binding to Human Adipocyte Plasma Membranes: Regional Variation in Omental and Subcutaneous Depots

      • Bessie Fong, Andrew Salter, Jose Jimenez, Jean-Pierre Despres, Aubie Angel
      Pages 61-66

    7. Clinical, Nutritional and Biochemical Consequences of Apolipoprotein B Deficiency

      • Herbert J. Kayden, Maret G. Traber
      Pages 67-81

  3. Hypoalphalipoproteinemia Syndromes

    1. Familial Hypoalphalipoproteinemia

      • Charles J. Glueck, Marc A. Melser, I. B. Borecki, Jane L. H. C. Third, D. C. Rao, Peter M. Laskarzewski
      Pages 83-92

    2. A Family Study of Hypoalphalipoproteinemia

      • C. Vergani, A. L. Catapano, A. Sidoli
      Pages 93-103

    3. Apoprotein A-I and Lecithin: Cholesterol Acyltransferase in a Patient with Tangier Disease

      • P. Haydn Pritchard, Jiri Frohlich
      Pages 105-110

    4. Severe Hypoalphalipoproteinemia Induced by a Combination of Probucol and Clofibrate

      • Jean Davignon, A. Christine Nestruck, Petar Alaupovic, Daniel Bouthillier
      Pages 111-125

    5. Control of Plasma HDL Levels After Plasmapheresis

      • G. R. Thompson, A. Jadhav
      Pages 127-135

    6. Clinical Syndrome and Lipid Metabolism in Hereditary Deficiency of Apolipoproteins A-I and C-III, Variant 1

      • Robert A. Norum, Trudy M. Forte, Petar Alaupovic, Henry N. Ginsberg
      Pages 137-149

    7. The Molecular Biology of Human ApoA-I, ApoA-II, ApoC-II and ApoB

      • Simon W. Law, Karl J. Lackner, Silvia S. Fojo, Ashok Hospattankar, Juan C. Monge, H. Bryan Brewer Jr.
      Pages 151-162

  4. LCAT and Cholesterol Transport

    1. Lecithin: Cholesterol Acyltransferase, a Review and Immunochemical Studies

      • Yves L. Marcel, Camilla A. Vézina, Philip K. Weech, François Tercé, Ross W. Milne
      Pages 163-179

    2. Lecithin: Cholesterol Acyltransferase (LCAT) Deficiency Syndromes

      • Jiri Frohlich, Roger McLeod
      Pages 181-194

    3. Cholesterol Efflux: Mechanism and Regulation

      • George H. Rothblat, Michael C. Phillips
      Pages 195-204

    4. Inhibition and Activation of Cholesteryl Ester Transfer and its Significance in Plasma Cholesterol Metabolism

      • Christopher J. Fielding
      Pages 205-210

  5. Hypertriglyceridemia Secondary to Enzyme or Apoprotein Deficiency

    1. Apolipoprotein C-II Deficiency

      • W. Carl Breckenridge
      Pages 211-226
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Keywords

About this book

Current interest in lipoprotein deficiency states stems from the growing realization of their importance in the etiology of premature coronary heart disease. While hypercholesterolemia and coronary heart disease risk are strongly correlated in their etiologic relationship, it is becoming equally clear that deficiencies in HDL, whether congenital or acquired, also enhance the risk for the future development of coronary atherosclerosis. This has led to renewed attention to the lipid hypothesis and realization of the fact that each lipoprotein class and apoprotein species has specific functions in the transport and cellular uptake of various lipids. It is a truism that a biochemical correlate of disease once identified is subsequently recognized with increasing frequency in clinical medicine. The story of HDL was no exception. Indeed hypoalphalipoproteinemia appears to be a disease of high prevalence approaching and perhaps even exceeding that of familial hypercholesterolemia. Its clinical signifi­ cance escaped our notice for many years largely due to a heavy emphasis on hypercholesterolemia and to difficulties in measuring HDL reliably.

Editors and Affiliations

  • Institute of Medical Sciences, University of Toronto, Toronto, Canada

    Aubie Angel

  • Shaughnessy Hospital, University of British Columbia, Vancouver, Canada

    Jiri Frohlich

Bibliographic Information

  • Book Title: Lipoprotein Deficiency Syndromes

  • Editors: Aubie Angel, Jiri Frohlich

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-1262-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1986

  • Softcover ISBN: 978-1-4684-1264-2Published: 23 October 2012

  • eBook ISBN: 978-1-4684-1262-8Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 303

  • Topics: Biochemistry, general

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