Purine and Pyrimidine Metabolism in Man V

1. Front Matter

   Pages i-xviii

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2. Adenosine Receptors

   1. Adenosine Receptors on Human T Lymphocytes and Human Thymocytes

      • Winand N. M. Dinjens, Rineke van Doorn, Jan P. R. M. van Laar-hoven, Dirk Roos, Wim P. Zeijlemaker, Chris H. M. M. de Bruijn

      Pages 1-6

   2. Adenosine Receptors on Human Lymphocytes

      • Gianni Marone, Sergio Vigorita, Massimo Triggiani, Mario Condorelli

      Pages 7-14

   3. Inhibition of Mast Cell Mediator Release by 5-Amino-4-Imidazolecarboxamide Riboside

      • Diana L. Marquardt, Harry E. Gruber

      Pages 15-18

   4. Purine Metabolism by Guinea-Pig Ileum

      • D. R. Webster, G. Boston, D. M. Paton

      Pages 19-28

   5. Suppression by 5′-Methylthioadenosine of Histamine or Leukotriene-Induced Contraction in Isolated Guinea Pig Tracheal Rings

      • Y. Nishida, S. Suzuki, T. Miyamoto

      Pages 29-33

   6. Adenosine Receptors on Human Basophils and Lung Mast Cells

      • Gianni Marone, Massimo Triggiani, Anne Kagey-Sobotka, Lawrence M. Lichtenstein, Mario Condorelli

      Pages 35-42

3. Purine Receptors and the CNS

   1. Hypoxanthine Uptake by Isolated Brain Microvessels

      • P. Cardelli-Cangiano, A. Fiori, A. Giacomello, R. Strom, C. Salerno

      Pages 43-46

   2. Morphine: Sites of Action in Guanosine Nucleoside Pathway

      • Major L. Cohn, Faye A. Eggerding, Antonio F. Machado, Stephan J. Cohn, Bart D. Waxman, Timothy Delaney

      Pages 47-52

   3. Purine and Monoamine Metabolites in Cerebrospinal Fluid

      • N. Lawrence Edwards, Faye S. Silverstein, Michael V. Johnston

      Pages 53-56

   4. Characteristics of High Affinity and Low Affinity Adenosine Binding Sites in Human Cerebral Cortex

      • David John, Irving H. Fox

      Pages 57-69

4. Nucleoside and Base Transport

   1. Hypoxanthine Transport Through Human Erythrocyte Membranes

      • E. Capuozzo, M. C. Gigante, C. Salerno, C. Crifò

      Pages 71-74

   2. Regulatory Aspects of Hypoxanthine Uptake by Human Erythrocytes

      • C. Salerno, G. Gerber, A. Giacomello

      Pages 75-77

   3. Mutant Mouse Cells with Nitrobenzylthioinosine-Insensitive Nucleoside Transport Functions

      • Bruce Aronow, Buddy Ullman

      Pages 79-83

   4. Carrier Mediated Uptake of Deoxyguanosine in Rat Liver Mitochondria

      • Linda Watkins, Roger A. Lewis

      Pages 85-88

5. Studies with Anti-Metabolites

   1. Mechanism of Thymineless Death

      • Mehran Goulian, Bruce M. Bleile, Lisa M. Dickey, Robert H. Grafstrom, Holly A. Ingraham, Scott A. Neynaber et al.

      Pages 89-95

   2. Enhancement of Methotrexate Cytotoxicity by Uracil Analogues that Inhibit Deoxyuridine Triphosphate Nucleotidohydrolase (dUTPase) Activity

      • William R. Beck, George E. Wright, Neil J. Nusbaum, James D. Chang, Eric M. Isselbacher

      Pages 97-104

   3. Influence of Methotrexate on Purine and Pyrimidine Pools and on Cell Phase Distribution of Cultured Human Lymphoblasts

      • Ronney A. De Abreu, Jos P. M. Bökkerink, Marinka A. H. Bakker, Tilly W. Hulscher, John M. van Baal, Chris H. M. M. de Bruijn et al.

      Pages 105-111

   4. Modulation of Cytotoxicity and Metabolism of 5-Fluorouracil in two Intestine Cell Lines

      • G. J. Peters, E. Laurensse, A. Leyva, H. M. Pinedo

      Pages 113-120

   5. Toxicity and Antitumor Effect of 5-Fluorouracil and its Rescue by Uridine

      • G. J. Peters, J. van Dijk, C. van Groeningen, E. J. Laurensse, A. Leyva, J. Lankelma et al.

      Pages 121-128

The Fifth International Symposium on Human Purine and Pyrimidine Metabolism was held in San Diego, California (U. S. A. ) in July and August of 1985. Previous meetings in this series were held in Tel Aviv (Israel), Baden (Austria), Madrid (Spain) and Maastricht (The Netherlands). The proceedings of each of these meetings were published by Plenum. The next meeting will be in Japan. This Symposium differed from those that went before in that it per­ mitted us to honor Dr. J. E. Seegmiller, Professor of Medicine at the University of California San Diego, for his many contributions to our understanding of purine metabolism in man. This publication is dedicated as a Festschrift to Jay. Dr. Richard W. E. Watts delivered the keynote address outlining in scholarly fashion the history of Dr. Seegmiller's accomplishments in research on purine metabolism and the great number of currently active scientists in this field who have worked with him. This address is published as the first contribution to Volume I. Dr. Dewitt Stetten, Jr. , was scheduled to be the speaker at our banquet. Unfortunate­ ly, he could not be with us. Dr. Seegmiller has written an appreciation of Dr. Stetten and his contributions to our field, and this has been pub­ lished following Dr. Watts' paper. The growth of knowledge in purine and pyrimidine metabolism continues to be exponential. The variety of subjects included in these volumes is impressive.

• growth
• infection
• interferon
• leukemia
• medicine
• metabolism
• muscle
• pharmacology
• research
• surgery

• University of California, San Diego La Jolla, USA

  W. L. Nyhan

• Scripps Clinic and Research Foundation, La Jolla, USA

  L. F. Thompson

• M. R. C. Clinical Research Center, Harrow, UK

  R. W. E. Watts

Policies and ethics