Chemotherapy of Parasitic Diseases

1. Front Matter

   Pages i-xxviii

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Historical Introduction

      • William C. Campbell

      Pages 3-21

3. Protozoa

   1. Front Matter

      Pages 23-23

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   2. Chemistry of Antiprotozoal Agents

      • John C. Chabala, Max W. Miller

      Pages 25-85

   3. Protozoan Infections of Man: Malaria

      • Timothy G. Geary, James B. Jensen

      Pages 87-114

   4. Protozoan Infections of Man: American Trypanosomiasis and Leishmaniasis

      • Patrick B. McGreevy, Philip D. Marsden

      Pages 115-127

   5. Protozoan Infections of Man: African Trypanosomiasis

      • Robert S. Rew

      Pages 129-137

   6. Protozoan Infections of Man: Other Infections

      • Joseph A. Kovacs, Henry Masur

      Pages 139-158

   7. Protozoan Infections of Domestic Animals: Coccidian and Related Infections

      • L. R. McDougald

      Pages 159-170

   8. Hemoprotozoan Infections of Domestic Animals: Trypanosomiasis, Babesiosis, Theileriosis, and Anaplasmosis

      • Kenneth L. Kuttler, Julius P. Kreier

      Pages 171-191

   9. Modes of Action of Antiprotozoal Agents

      • Douglas L. Looker, J. Joseph Marr, Ronald L. Stotish

      Pages 193-207

   10. Drug Resistance in Protozoa

       • Timothy G. Geary, S. Allen Edgar, James B. Jensen

       Pages 209-236

4. Nematodes

   1. Front Matter

      Pages 237-237

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   2. Chemistry of Antinematodal Agents

      • Michael H. Fisher

      Pages 239-266

   3. Nematode Infections of Man: Intestinal Infections

      • David Botero

      Pages 267-276

   4. Nematode Infections of Man: Extraintestinal Infections

      • David A. Denham

      Pages 277-286

   5. Nematode Infections of Domestic Animals: Gastrointestinal Infections

      • Susan Marriner, James Armour

      Pages 287-305

   6. Nematode Infections of Domestic Animals: Extraintestinal Infections

      • Lyndia Slayton Blair, Thomas R. Klei

      Pages 307-319

   7. Mode of Action of Antinematodal Drugs

      • Robert S. Rew, Raymond H. Fetterer

      Pages 321-337

"Have a chew of dulie," said Crubog . . . "What is it?" asked Potter, half-suspiciously. "Seaweed. " "Is it good for the virility? . . . " "And what is the virility?" asked the old man. "Does it make you more attractive to women?" Potier shouted in his ear. "No. " "What is it good for then?" "WortnS. " "Worms?" "Intestinal worms. You'll never again pass a worm if you eat a fistful of dulse first thing in the morning and last thing at night. " "If it's an anthelmintic, I'll try a spot of it," said Potter. - From Bogmail, a novel by Patrick McGinley (1981) With modern techniques of chemical isolation and structure determination, the old distinction between herbal and chemical remedies has largely been broken down. By chemotherapy we now mean simply the treatment of disease by drugs (the word medicines has unhappily been eclipsed). The distinction made between chemotherapy and non­ chemical therapy (e. g. , radiation, physiotherapy, surgical intervention, immu­ nomodulation) remains useful despite some minor overlapping. The present work thus deals with drugs and their use in parasitic disease. (Since we are dealing with the treatment of incipient as well as established infection, chemotherapy subsumes chem­ oprophylaxis as well as chemotherapeusis per se. ) Definition of parasitism as a biological modus vivendi, although important in itself, need not concern us here. We need simply delimit the scope of the book, and that is easily done.

• Malaria
• Schistosomiasis
• antibiotics
• chemotherapy
• clinical trial
• infection
• infections
• intestinal infections
• metabolism
• pesticide
• pharmacology
• prevention
• protozoan infection
• toxicity
• toxicology
• infectious diseases

• Merck Institute for Therapeutic Research, Rahway, USA

  William C. Campbell

• Merck Sharp & Dohme Research Laboratories, Rahway, USA

  Robert S. Rew

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