The Cell Membrane

1. Front Matter

   Pages N1-ix

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2. Herman Kalckar: An Appreciation

   1. Herman Kalckar: An Appreciation

      • Edgar Haber

      Pages 1-3

3. The Cell Membrane of Procaryotes

   1. Front Matter

      Pages 5-5

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   2. Outer Membrane Permeability of Gram-Negative Bacteria in their Interaction with the Outside World

      • Hiroshi Nikaido

      Pages 7-17

   3. Biogenesis of Membrane Lipoproteins in Bacteria

      • Henry C. Wu

      Pages 19-31

   4. Periplasmic Membrane-Derived Oligosaccharides and Osmoregulation in Escherichia Coli

      • Eugene P. Kennedy

      Pages 33-43

   5. Approaches to the Biochemistry of Protein Secretion in Bacteria

      • Bernard D. Davis, Stephen Lory, Michael Caulfield, P. C. Tai

      Pages 45-54

   6. Two Mechanisms of Biosyntheses of Antibiotic Peptides

      • Kiyoshi Kurahashi, Chika Nishio

      Pages 55-66

   7. Transmembrane Channels Made by Colicins

      • S. E. Luria

      Pages 67-69

   8. Significance of Lipopolysaccharide Structure for Questions of Taxonomy and Phylogenetical Relatedness of Gram-Negative Bacteria

      • Hubert Mayer

      Pages 71-83

   9. Cloning and Expression of Genes Encoding the nupG Nucleoside Transport System in Escherichia Coli

      • Agnete Munch-Petersen, Nina Jensen

      Pages 85-99

   10. From Herman Kalckar’s Galactose Recapture to the Galactose Chemoreceptor

       • Winfried Boos

       Pages 101-107

   11. Glycerol Utilization by Facilitated Diffusion Coupled to Phosphorylation in Bacteria

       • E. C. C. Lin

       Pages 109-130

   12. Mechanisms of Cellular Protein Localization

       • S. A. Benson, E. Bremer, S. Garrett, D. R. Kiino, J. W. Shultz, T. J. Silhavy et al.

       Pages 131-146

4. The Cell Membrane of Eukaryotes

   1. Front Matter

      Pages 147-147

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   2. Ektobiology, Growth Control and Cancer

      • Arthur B. Pardee

      Pages 149-159

   3. Carbohydrate Antigens of Cell Surfaces Detected by Monoclonal Antibodies

      • Victor Ginsburg

      Pages 161-168

   4. Studies on a Cancer Associated Glycoprotein

      • Kurt J. Isselbacher, Daniel K. Podolsky

      Pages 169-179

   5. Glycosphingolipids as Markers for Development and Differentiation and as Regulators of Cell Proliferation

      • Sen-itiroh Hakomori

      Pages 181-201

   6. Probing the Macrophage Surface: Alterations in Specific Surface Carbohydrates Accompany Macrophage Activation

      • Arthur M. Mercurio, Gerald A. Schwarting, Phillips W. Robbins

      Pages 203-215

The contents of this book reflect a symposium held in honor of Professor Herman Kalckar's seventy-fifth birthday. His impact on the history of biochemistry is reflected by the diversity of the contributions of his former students and friends. Speakers came from Asia, Europe, and the United States to discuss both procaryotes and eukaryotes. The unifying theme was the cell membrane, both its organization and its function. Ektobiology, a topic that has held the attention of Professor Kalckar for many years, was clearly defined as a central topic in biology. This subject deals with the key structure whereby the cell interacts with the outside world and which, in a sense, defines the boundary between what is the cell and what is not. Topics discussed include the biogenesis of membrane proteins, sugars and lipids, the role of membrane components in osmoregula­ tion, and mechanisms of nutrient transport. Of great interest is the system for surface recognition evolved in vertebrates, exemplified by the HLA system of man. Neoplasia causes changes in the cell membrane that may be of significant future potential in the diagnosis and treatment of malignancies as well as in the understanding of the process of transformation. The changes in glycosphingolipids and carbohydrate antigens in relation to oncogenesis are detailed. I should like to recognize Doctors Kurt J. Isselbacher, Phillips W. Robbins, Victor Ginsburg, and Hiroshi Nikaido for their ,assistance in organizing the symposium. Ms. Jean Brumbaugh deserves special thanks for putting this book together.

• biochemistry
• biology
• cell membrane
• oncogene
• protein
• proteins

• Harvard Medical School, Massachusetts General Hospital, Boston, USA

  Edgar Haber

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