Overview
- Editors:
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David W. McCandless
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Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, USA
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Table of contents (19 chapters)
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Front Matter
Pages i-xxii
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Metabolic Encephalopathy Associated with Severe Interruption of Substrate
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- David W. McCandless, Marc S. Abel
Pages 27-41
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- W. David Lust, Hajime Arai, Yukimasa Yasumoto, Tim S. Whittingham, Bogden Djuricic, Bogomir B. Mrsulja et al.
Pages 79-117
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Metabolic Encephalopathy Resulting Primarily from Intrinsic Factors
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Front Matter
Pages 119-119
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- Leslie Zieve, Gorig Brunner
Pages 179-201
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- Gerard B. Odell, Henry S. Schutta
Pages 229-261
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- Paul E. Teschan, Allen I. Arieff
Pages 263-285
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Metabolic Encephalopathy That May Result from Extrinsic Factors
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Front Matter
Pages 309-309
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- Jean Holowach Thurston, Richard E. Hauhart, John A. Dirgo, David B. McDougal Jr.
Pages 353-359
About this book
In recent years, there has been rapid growth in knowledge pertaining to the nervous system. This has, in some measure, been due to the development and application of a number of techniques such as the 2-deoxyglucose method and microchemical methods for measuring metabolites and regional cerebral blood flow. Data from the application of these techniques are just beginning to be collected, and the next few years promise to bring many new and exciting findings. The study of energy metabolism in brain is particularly interesting due to the fact that although the brain has scant energy reserves (as compared with the liver), it has one of the highest metabolic rates in the body. Recent studies from several laboratories have shown a surprising divergence of re sponses to metabolic insult in different areas of brain. In this regard, the cer ebellum, for example, may have metabolic features which are uniqve from those of any other region. The high-energy phosphate compounds ATP and phos phocreatine, supplied by the oxidative metabolism of glucose, are necessary for normal cerebral functions such as the maintenance of membrane potentials, transmission of impulses, and synthetic processes. Interruption of substrate or "poisoning" of the system by a variety of means lead to a rapid change in cellular energetics, and ultimately cell death. From the clinical standpoint, an interesting feature of metabolic encephalopathy is that in many cases, early diagnosis and treatment may result in a rapid reversal of symptoms.
Editors and Affiliations
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Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, USA
David W. McCandless
