Neurobiology of Cerebrospinal Fluid 1

1. Front Matter

   Pages i-xxvii

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2. Physiology, Pharmacology, and Dynamics of Cerebrospinal Fluid

   • James H. Wood

   Pages 1-16

3. Role of Cyclic AMP in Cerebrospinal Fluid Production

   • Arthur M. Feldman, Mel H. Epstein, Saul W. Brusilow

   Pages 17-27

4. Chemical Alterations of Cerebrospinal Fluid Acting on Respiratory and Circulatory Control Systems

   • Hans H. Loeschcke

   Pages 29-40

5. Neurochemical Aspects of Blood-Brain-Cerebrospinal Fluid Barriers

   • Robert W. P. Cutler

   Pages 41-51

6. Sites of Origin and Cerebrospinal Fluid Concentration Gradients

   • James H. Wood

   Pages 53-62

7. Daily Fluctuations in Catecholamines, Monoamine Metabolites, Cyclic AMP, and γ-Aminobutyric Acid

   • Mark J. Perlow, C. Raymond Lake

   Pages 63-69

8. Technical Aspects of Clinical and Experimental Cerebrospinal Fluid Investigations

   • James H. Wood

   Pages 71-96

9. Cerebrospinal Fluid Amine Metabolites and the Probenecid Test

   • Michael H. Ebert, Ronald Kartzinel, Rex W. Cowdry, Frederick K. Goodwin

   Pages 97-112

10. Extracellular Cyclic Nucleotide Metabolism in the Human Central Nervous System

    • Benjamin Rix Brooks, James H. Wood, Maria Diaz, Carol Czerwinski, Leon P. Georges, Jonas Sode et al.

    Pages 113-139

11. Norepinephrine in Cerebrospinal Fluid

    • Michael G. Ziegler, C. Raymond Lake, James H. Wood, Michael H. Ebert

    Pages 141-152

12. Huntington’s Disease

    • Ian J. Butler, William E. Seifert, S. J. Enna

    Pages 153-160

13. Cerebrospinal Fluid Noradrenergic and Behavioral Alterations Associated with Stimulation and Atrophy of the Caudate Nucleus

    • James H. Wood, Michael G. Ziegler, C. Raymond Lake, Ira Shoulson, Benjamin Rix Brooks

    Pages 161-169

14. Evaluation of Cerebrospinal Fluid γ-Aminobutyric Acid Content in Neurological and Psychiatric Disorders

    • Theodore A. Hare, N. V. Bala Manyam, Bruce S. Glaeser

    Pages 171-187

15. Cerebrospinal Fluid γ-Aminobutyric Acid Correlation with Cerebrospinal Fluid and Blood Constituents and Alterations in Neurological Disorders

    • S. J. Enna, Michael G. Ziegler, C. Raymond Lake, James H. Wood, Benjamin Rix Brooks, Ian J. Butler

    Pages 189-196

16. Cerebrospinal Fluid Studies in Parkinson’s DiseaseNorepinephrine and γ-Aminobutyric Acid Concentrations

    • Paul F. Teychenne, C. Raymond Lake, Michael G. Ziegler

    Pages 197-206

17. Neurochemical Alterations in Parkinson’s Disease

    • Thomas N. Chase

    Pages 207-218

18. Cerebrospinal Fluid Monoamine Metabolites in Neurological Disorders of Childhood

    • Bennett A. Shaywitz, Donald J. Cohen, Malcolm B. Bowers Jr.

    Pages 219-236

19. Seizure-Induced Metabolic Alterations in Human Cerebrospinal Fluid

    • Benjamin Rix Brooks

    Pages 237-257

20. Neurotransmitter, Metabolite, and Cyclic Nucleotide Alterations in Cerebrospinal Fluid of Seizure Patients

    • James H. Wood, Benjamin Rix Brooks

    Pages 259-278

Physiologic compartmentalization effectively isolates the central nervous system from the rest of the body. This isolation not only provides protection of its delicate function from aberrant peripheral influences but also impedes its diagnostic evaluation. Cerebro­ spinal fluid (CSF) bathes the brain and spinal cord, is in dynamic equilibrium with its extracellular fluid, and tends to reflect the state of health and activity of the central nervous system. CSF examination is the most direct and popular method of assessing the central chemical and cellular environment in the living patient or mammal. The purpose of this multidisciplined reference text is to provide the sophisticated knowledge of CSF physiology and pathology necessary for the meaningful interpretation of data obtained by various types of CSF analysis. The methodology for reliable CSF collection, storage, preparation, and analysis is discussed with respect to individual, somatotropic, chronologic, endorcinologic, pharmacologic, and possible artifactual var­ iations in CSF composition. These essential aspects, which ensure the validity of CSF data, are presented to aid the investigator in clinical and experimental protocol formu­ lation and in elimination of possible sources of error.

• biology
• brain
• neurobiology
• physiology

• Division of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, USA

  James H. Wood

• Pediatric Oncology Branch, National Cancer Institute National National Institutes of Health, Bethesda, USA

  James H. Wood

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