The Molecular Biology of Picornaviruses

1. Front Matter

   Pages i-xiv

   PDF

2. The Structure of the Picornavirion

   1. Front Matter

      Pages xv-xv

      PDF

   2. The Picornavirion: Structure and Assembly

      • Douglas G. Scraba

      Pages 1-23

   3. General Organization and Structure of the Picornavirus Genome

      • Peter Fellner

      Pages 25-47

   4. Structure-Function Relationships in the Picornaviruses

      • F. Brown

      Pages 49-72

3. Early Events During the Infectious Process: Shut-off of Cellular Synthesis

   1. Front Matter

      Pages N1-N1

      PDF

   2. Inhibition of Cellular Protein Synthesis After Virus Infection

      • Jean M. Lucas-Lenard

      Pages 73-99

   3. The Role of Initiation Factors in the Shut-Off of Protein Synthesis

      • G. Baglioni, P. A. Maroney, M. Simili

      Pages 101-111

4. Synthesis and Processing of Viral Proteins

   1. Front Matter

      Pages N3-N3

      PDF

   2. Synthesis and Processing of Picornaviral Polyprotein

      • R. R. Rueckert, T. J. Matthews, O. M. Kew, M. Pallansch, C. McLean, D. Omilianowski

      Pages 113-125

   3. Virus-Directed Protein Synthesis

      • Jean M. Lucas-Lenard

      Pages 127-147

   4. Role of Cellular and Viral Proteases in the Processing of Picornavirus Proteins

      • Bruce D. Korant

      Pages 149-173

   5. The Genome-Linked Protein of Picornaviruses: Discovery, Properties and Possible Functions

      • Eckard Wimmer

      Pages 175-190

5. On Decoding the Viral mRNA

   1. Front Matter

      Pages N5-N5

      PDF

   2. The Mechanism and Cytoplasmic Control of Mammalian Protein Synthesis

      • Richard J. Jackson

      Pages 191-222

   3. In Vitro Translation of Picornavirus RNA

      • Elvera Ehrenfeld

      Pages 223-238

6. Translational Regulation: Mechanism of Action of Interferon

   1. Front Matter

      Pages N7-N7

      PDF

   2. The Interferon System: Studies on the Molecular Mechanism of Interferon Action

      • M. Revel, A. Kimchi, A. Schmidt, L. Shulman, A. Zilberstein

      Pages 239-253

   3. On the Action of Interferon in Uninfected and Mengovirus-Infected Cells

      • R. Falcoff, O. Aujean, J. A. Lewis, E. Falcoff

      Pages 255-277

   4. Interferon-Induced Activation of an Endonuclease by 2′ 5′ Oligo (A)

      • C. Baglioni, P. A. Maroney, G. E. Chatterjee, M. A. Minks

      Pages 279-292

vi The intent, therefore, was to provide for a fresh and original review of all relevant topics and issues in the field, following a comprehensive and coherent programme. Such an ambitious goal could only be reached thanks to the unlimited collaboration of the lecturers: They were requested to produce nothing less than "freer, broader, speculative and personal "considerations of the subjects" they had to cover ••• And so they did: their presentations unfolded a fantastic picture, a most fascinating and meaningful identification of the field, its present problems and trends. But participants at this conference contributed many valuable observations while discussing specific points. Unfortunately, more often than not, it proved impossible to identify them in the records. Accordingly, we incorporated here and there some of these "anonymous" contributions as part of the edited version of the texts. To all of the participants, I would like to express my gratitude for their actively taking part in all the scientific (and social ••• ) activities (lectures, round tables, posters, encounters) of this N.A.T.O. ASl. The result was a stimulating atmosphere, conducive to authentic scientific exchanges. Hence, the success of this meeting should be credited only to them. Finally, on behalf of all participants, I would like to thank Professor Sissini, the Mayor of Maratea, and Mr. B. Vitolo, the Chairman of its Tourist Office: their enthusiastic support greatly contributed to make of our time in their wonderful seaside resort an unforgettable one.

• Mammalia
• RNA
• Viruses
• atmosphere
• biology
• molecular biology
• protein
• translation
• virus

• Laboratory of Virology and Molecular Biology, Institute of Anatomy, University of Zurich, Zurich, Switzerland

  R. Pérez-Bercoff

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