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Cell Substrates

Their Use in the Production of Vaccines and Other Biologicals

  • Book
  • © 1979

Overview

Editors:
  1. John C. Petricciani

    1. Bureau of Biologics of the Food and Drug Administration, Bethesda, USA

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  2. Hope E. Hopps

    1. Bureau of Biologics of the Food and Drug Administration, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Paul J. Chapple

    1. W. Alton Jones Cell Science Center, Lake Placid, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 118)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-viii
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  2. Past Achievements — Future Expectations

    1. Past Achievements — Future Expectations

      • Harry M. Meyer Jr.
      Pages 1-5

  3. Cell Substrates: General Overview

    1. Introductory Remarks

      • Saul Krugman
      Pages 7-7

    2. Cell Substrates for Biologics Production: Factors Affecting Acceptability

      • John C. Petricciani
      Pages 9-21

    3. Quantitation in the Evaluation of Cell Substrates for Viral Vaccine Production

      • Wade P. Parks, Elizabeth S. Hubbell
      Pages 23-33

    4. Human Cells and the Finite Lifespan Theory

      • Thomas B. L. Kirkwood, Robin Holliday
      Pages 35-46

    5. Line Cell Saga — An Argument in Favor of Production of Biologics in Cancer Cells

      • Maurice R. Hilleman
      Pages 47-58

  5. Cell Substrates for Biologicals other than Vaccines

    1. Introductory Remarks

      • Jan Vilček
      Pages 115-116

    2. Interferon as a Cell Product

      • Jan Vilcek
      Pages 117-127

    3. Urokinase as a Cell Product

      • Joseph C. Fratantoni
      Pages 129-133

    4. Production of Biologicals by Plant Cell Cultures

      • Donald K. Dougall
      Pages 135-152

    5. Use of Recombinant DNA Technology for the Production of Polypeptides

      • Walter L. Miller
      Pages 153-174

    6. Molecular Biology and Public Health

      • Robert R. Wagner
      Pages 175-183

  6. Summary and Considerations for the Future

    1. Introductory Remarks

      • Thomas C. Merigan
      Pages 185-185

    2. Benefit-Risk Assessment

      • H. Bruce Dull
      Pages 187-193
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Keywords

About this book

This volume stems from a symposium sponsored by the W. Alton Jones Cell Science Center, Lake Placid New York. The Second Annual W. Alton Jones Cell Science Center Symposium: Cell Substrates and­ Their Use in the Production of Vaccines and Other Biologicals was held October 23-26, 1978. The Center is an operational unit of the Tissue Culture Association and offers, in collaboration with the Association's Education Committee, a wide range of educational and research activities. During the past 20 years there have been numerous national and international conferences on the topic of cell cultures used to produce biological products. Those largely dealt with the technology and associated issues that were current at the time of the meetings. For example, as human diploid cells were developed and proposed for use in vaccine production, a number of meetings were held to examine the pros and cons of human diploid cells. A large amount of data was provided at those conferences which formed the basis for the eventual acceptance of that cell system. Each meeting added to the general base of knowledge in the area of cell cultures and their application to the current and novel set of problems encountered. In general, the participants reaffirmed the basic premises that were formulated in the early days of polio virus vaccine production regarding the criteria for acceptability of cells when used in the manufacture of biologics intended for humans.

Editors and Affiliations

  • Bureau of Biologics of the Food and Drug Administration, Bethesda, USA

    John C. Petricciani, Hope E. Hopps

  • W. Alton Jones Cell Science Center, Lake Placid, USA

    Paul J. Chapple

Bibliographic Information

  • Book Title: Cell Substrates

  • Book Subtitle: Their Use in the Production of Vaccines and Other Biologicals

  • Editors: John C. Petricciani, Hope E. Hopps, Paul J. Chapple

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-0997-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1979

  • Softcover ISBN: 978-1-4684-0999-4Published: 17 June 2012

  • eBook ISBN: 978-1-4684-0997-0Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 220

  • Topics: Pharmacology/Toxicology, Cell Biology

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