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Chromatin Structure and Function

Levels of Organization and Cell Function Part B

  • Book
  • © 1979

Overview

Editors:
  1. Claudio A. Nicolini

    1. Temple University, Philadelphia, USA

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Part of the book series: NATO Science Series A: (NSSA, volume 21b)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xix
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  2. Various Levels of Chromatin Organization and Mechanisms for Transcriptional Control

    1. Front Matter

      Pages 369-369
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    2. Histones Assembly and Their Structural Role for Nucleosome Core

      • N. M. Maraldi, S. Capitani, L. Cocco, F. A. Manzoli
      Pages 371-388

    3. Nuclease Digestion and the Structure of Chromatin

      • K. E. Van Holde, J. R. Allen, J. Corden, D. Lohr, K. Tatchell, W. O. Weischet
      Pages 389-412

    4. Reconstitution of Nucleosomes

      • K. Tatchell, K. E. Van Holde
      Pages 413-425

    5. Conformation of Polynucleosomes in Low Ionic Strength Solution

      • Barbara Ramsay Shaw, Kenneth S. Schmitz
      Pages 427-440

    6. Chromatin Structure: Relation of Nucleosomes of DNA Sequence

      • Ariel Prunnel
      Pages 441-449

    7. Histone Complexes, Nucleosomes, Chromatin and Cell-Cycle Dependent Modification of Histones

      • H. W. E. Rattle, G. G. Kneale, J. P. Baldwin, H. R. Matthews, C. Crane-Robinson, P. D. Cary et al.
      Pages 451-513

    8. Evidence for Superstructures of Wet Chromatin

      • Samarendra Basu
      Pages 515-540

    9. Chromatin Fractionation and the Properties of Transcriptionally Active Regions of Chromatin

      • Joel M. Gottesfeld
      Pages 541-560

    10. Chromatin Reconstitution and Non-Histone Proteins

      • R. Stewart Gilmour
      Pages 561-591

  3. Structure-Function of the Genetic Apparatus and Cell Cycle, Aging, Neoplastic Transformation, Differentiation, Chemical Carcinogenesis

    1. Front Matter

      Pages 597-597
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    2. The Structure and Function of Chromatin in Lower Eukaryotes

      • K. E. Davies, I. O. Walker
      Pages 599-611

    3. Chromatin Structure, from Angstrom to Micron Levels, and Its Relationship to Mammalian Cell Proliferation

      • C. Nicolini
      Pages 613-666

    4. Chromatin Pattern in Situ: Dependence upon Cell Cycle, Preimplantation Development and Cellular Aging in Vitro

      • Wojciech Sawicki
      Pages 667-681

    5. Neoplastic Transformation: The Relevance of In Vitro Studies for the Understanding of Tumor Pathenogenesis and Neoplastic Growth

      • L. A. Smets
      Pages 683-704

    6. Cell Differentiation and Malignancy in Leukemia

      • Leo Sachs
      Pages 705-720

    7. Cellular Morphometry in Transformation, Differentiation, and Aging

      • S. Parodi, G. Brambilla, F. Beltrame, S. Lessing, C. A. Nicolini
      Pages 721-749

    8. Basic Mechanisms in Chemical Carcinogenesis

      • Paul O. P. Ts’o
      Pages 751-769

    9. Carcinogen Induced Alteration in Gene Packing and Its Possible Significance in Carcinogenesis

      • P. M. Rao, S. Rajalakshmi, D. S. R. Sarma
      Pages 771-779
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Keywords

About this book

This volume is the second part of the book on "Chromatin Structure and Function", which resulted from a NATO-Advanced Study Institute held at Erice during April 1978. In addition to giving an updated and detailed description of various levels of chromatin organization, i. e. octamers, nucleosomes, multimers, solenoid and higher order fibers (including the most recent, yet unpublished, findings), it focuses, in a tutorial and organic format, on the possible mechanisms controlling transcription and on the basic biological phenomena (either genetic or epigenetic) related to cell aging, cell cycle, differentiation, transformation and chemical carcinogenesis. The most significant (sometime spirite~ discussion sessions have been included at the end of every section. Their clarifying nature is further supported by the final section (V), which summarizes and reviews the current state of the art on the genetic apparatus and its constituents. All chapters have selected up-to-date references; quite a few have an extensive bibliography both in terms of basic reference books and most recent findings. A few chapters, dealing at the level of intact cell and/or in classical genetic terms, with aging, differentiation and neoplastic transformation, have been included to furnish a more comprehensive view of fundamental cell functions directly and indirectly related to the structure and function of the genetic apparatus. At the same time it is hoped that interested students and investigators will find in the chapters of this volume the necessary and stimulating introduction to the wide variety of fundamental mechanism and phenomena occurring in higher eukaryotes.

Editors and Affiliations

  • Temple University, Philadelphia, USA

    Claudio A. Nicolini

Bibliographic Information

  • Book Title: Chromatin Structure and Function

  • Book Subtitle: Levels of Organization and Cell Function Part B

  • Editors: Claudio A. Nicolini

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-0976-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1979

  • Softcover ISBN: 978-1-4684-0978-9Published: 16 April 2013

  • eBook ISBN: 978-1-4684-0976-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXII, 514

  • Topics: Biochemistry, general

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