Heparin

1. Front Matter

   Pages i-x

   PDF

2. Structural Aspects

   1. Front Matter

      Pages 1-1

      PDF

   2. Molecular Properties

      1. The Chemistry of Heparin

         • Roger W. Jeanloz

         Pages 3-17

      2. Crystalline Structure of Heparin

         • Edward D. T. Atkins, Ian A. Nieduszynski

         Pages 19-37

      3. Three-Dimensional Model of Heparin

         • Leon Yuan, Salvatore S. Stivala

         Pages 39-49

   3. Biosynthesis

      1. Heparin and Heparin-Like Substances of Cells

         • Jeremiah E. Silbert, Hynda K. Kleinman, Cynthia K. Silbert

         Pages 51-60

      2. Biosynthesis of Heparin

         • Gudrun Bäckström, Anund Hallen, Magnus Höök, Leif Jansson, Ulf Lindahl

         Pages 61-77

      3. Metabolism of Macromolecular Heparin in Murine Neoplastic Mast Cells

         • Sören Ögren, Ulf Lindahl

         Pages 79-83

      4. Demonstration of Endogenous Heparin in Rat Blood

         • Alan A. Horner

         Pages 85-93

   4. Biological Properties

      1. Relation of Chemical Structure of Heparin to Its Anticoagulant Activity

         • J. A. Cifonelli

         Pages 95-103

      2. Synthesis and Properties of Heparin Derivatives

         • I. Danishefsky

         Pages 105-118

      3. Low-Molecular-Weight Derivative of Heparin that is Orally Active in Mice

         • Sigmund E. Lasker

         Pages 119-130

      4. Heparin is an Anionic Hydrated Anticoagulant

         • Herbert L. Davis

         Pages 131-137

   5. Analytical and Pharmacological Considerations

      1. What is “Heparin”?

         • Louis B. Jaques

         Pages 139-147

      2. Determination of Heparin in Small Tissue Samples

         • Louis B. Jaques

         Pages 149-154

      3. Identification and Quantification of Tissue Heparin by Microelectrophoresis: A Critique

         • Alan A. Horner

         Pages 155-162

      4. Standards for Heparin

         • Milica Brozovic, D. R. Bangham

         Pages 163-179

      5. Application of the Kinetics of Heparin to the Formulation of Dosage Schedules

         • J. Worth Estes

         Pages 181-192

3. Functional Aspects

   1. Front Matter

      Pages 193-193

      PDF

   2. Effect on Blood Coagulation: Interaction with Antithrombin III

      1. Antithrombin III: A Backward Glance O’Er Travel’d Roads

         • Walter H. Seegers

         Pages 195-215

The International Symposium on Heparin, held May 13-15, 1974, in St. Louis, Missouri, as a part of the dedication of the Shoenberg Pavilion of the Jewish Hospital of St. Louis, was conceived as a forum to bring together physicians and scientists with a basic in­ terest in the structure, function and clinical usefulness of heparin. Few naturally occurring substances have commanded the breadth of interest among members of the biomedical research community as this compound has. Aspects of its covalent and three-dimensional struc­ ture, its biosynthesis, its interaction with and effect on physio­ logically important moieties and its use as a therapeutic agent in a variety of disease states have been actively studied for the past several decades. Thus, the present state of these studies seemed to be a timely subject for discussion, not only to gather together in one place representative samples of the myriad of data on heparin but also to underscore the ever increasing necessity for communica­ tion between basic research and clinical practice.

• Lipoprotein
• artery
• biomedical research
• biosynthesis
• blood
• embolism
• hospital
• metabolism
• myocardial infarction
• plasma
• platelet
• research
• thrombosis

• Department of Biological Chemistry, Washington University School of Medicine, St. Louis, USA

  Ralph A. Bradshaw

• Department of Medicine, The Jewish Hospital, St. Louis, USA

  Stanford Wessler

• Washington University School of Medicine, St. Louis, USA

  Stanford Wessler

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