DNA Synthesis

1. Front Matter

   Pages i-xiv

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2. Initiation and Control of Replication

   1. Control of DNA Replication in Bacteria

      • R. H. Pritchard

      Pages 1-26

   2. Map Position of the Replication Origin of the E.coli K12 Chromosome

      • Olivier Fayet, Jean-Michel Louarn

      Pages 27-31

   3. An Approach to the Isolation of the Replication Origin of Bacillus Subtilis

      • Scott Winston, Noboru Sueoka

      Pages 33-39

   4. Stability of Origin-RNA and its Implications on the Structure of the Origin of Replication in E.coli

      • John E. Womack, Walter Messer

      Pages 41-48

   5. The Genetics of E.Coli DNA Replication

      • James A. Wechsler

      Pages 49-70

   6. Characterization of Chromosomal Replication in a dnaA Mutant

      • Joe A. Fralick

      Pages 71-83

   7. Genetic and Physiological Properties of an Escherichia Coli Strain Carrying the dnaA Mutation T46

      • E. Orr, P. A. Meacock, R. H. Pritchard

      Pages 85-99

   8. The Function of RNA Polymerase and dnaA in the Intitiation of Chromosome Replication in Escherichia coli and Salmonella Typhimurium

      • Miroslawa M. Bagdasarian, Maryla Izakowska, Renata Natorff, Michael Bagdasarian

      Pages 101-111

   9. Stabilized Initiation Activity of DNA Replication in an Sdr^c Mutant of Escherichia Coli

      • T. Kogoma, M. J. Cunnaughton, B. A. Alizadeh

      Pages 113-120

   10. Replication of Bacteriophage Mu: Direction and Possible Location of the Origin

       • Theo Goosen

       Pages 121-126

   11. Control of the Initiation of Lambda Replication, oop, lit and Repressor Establishment RNA Synthesis

       • Sidney Hayes

       Pages 127-142

   12. Control of Initiation of DNA Replication in Mammalian Cells

       • J. Herbert Taylor

       Pages 143-159

   13. Developmental Considerations of Eukaryotic DNA Replication and Replicon Size

       • Peter J. Stambrook, Douglas J. Burks

       Pages 161-174

   14. The Organization of DNA Replication in a Mammalian Cell Line

       • Barbara R. Jasny, Joel E. Cohen, Igor Tamm

       Pages 175-188

   15. An Unusual Structure Implicated in Initiation of DNA Synthesis

       • Timothy Nilsen, Corrado Baglioni

       Pages 189-201

   16. Inhibition of DNA Synthesis by 1-β-D-Arabinofuranosylcytosine: Differential Effect on Chain Initiation and Elongation in Human Lymphoblasts

       • Arnold Fridland

       Pages 203-217

3. The Biosynthesis of Chromosomal DNA

   1. Thymidine Metabolism in Bacteria (and “How, or How Not, to Label DNA”)

      • Gerard A. O’Donovan

      Pages 219-253

   2. Deoxyribonucleoside Triphosphates and DNA Polymerase in Bacteriophage PBS1-Infected Bacillus Subtilis

      • Ronald A. Hitzeman, Alan R. Price, Jan Neuhard, Henrik Møllgaard

      Pages 255-266

   3. In Vivo Synthesis and Properties of Uracil-Containing DNA

      • Huber R. Warner, Bruce K. Duncan

      Pages 267-279

This book represents the proceedings of the NATO Advanced Study Institute held in Santa Flavia, Sicily from the 20 - 29th June, 1977. In addition to the review talks given by the Lecturers at the Institute it proved feasible for other topics to be splendidly reviewed. This has led to a much wider subject coverage than would otherwise have been possible. The discussion sessions which followed these review talks were extremely valuable and almost all the participants played an active role. Essentially all of the verbal contributions presented at this ASI were subsequently put into written format, which is why these proceedings are so extensive. ~hey do, however, provide an up-to-date summary of DNA synthesis in a wide variety of subjects with many of the remaining problems clearly expressed. The editing of these contributions has been essentially confined to alterations in style and presentation. We have taken some liberties in the re-organization of the papers into related sections. We express our thanks to those who helped organize the ASI and to the session conveners who attempted to confine and contain those who became too verbose. We are indebted to NATO, Scientific Affairs Division for the financial support that made this ASI possible. Finally, we express our gratitude to Miss Brenda Marriott. She typed all seventy five papers in this book, which was originally estimated to be less than half its present length and which just grew and grew. She deserves our special thanks.

• DNA
• Mammalia
• development
• genetics
• paper
• synthesis
• system

• Imperial Cancer Research Fund, London, England

  Ian Molineux

• University of Paris, Paris, France

  Masamichi Kohiyama

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