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Steroid Hormone Receptors: Basic and Clinical Aspects

  • Book
  • © 1994

Overview

Editors:
  1. V. K. Moudgil

    1. Department of Biological Sciences, Oakland University, Rochester, USA

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Part of the book series: Hormones in Health and Disease (HHD)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xiv
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  3. Steroid Receptor Interactions With DNA and Nuclear Components

    1. Front Matter

      Pages 45-45
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    2. Structural and Functional Studies of Selective DNA Binding by Steroid/Nuclear Receptors

      • Leonard P. Freedman, Ben F. Luisi, Iris Alroy, Terri L. Towers
      Pages 47-73

    3. Estrogen Receptor Induced DNA Bending

      • David J. Shapiro, Geoffrey L. Greene, Ann M. Nardulli
      Pages 75-105

    4. The Nuclear Environment and Estrogen Action

      • Jerry R. Malayer, Jack Gorski
      Pages 107-129

    5. Functional Interaction of the Estrogen Receptor with the Tissue-Specific, Homeodomain Transcription Factor, PIT-1

      • Richard A. Maurer, Richard N. Day, Yasuhiko Okimura, Barbara E. Nowakowski
      Pages 131-161

    6. Insights into the Genomic Mechanism of Action of 1,25-Dihydroxyvitamin D3

      • J. Wesley Pike
      Pages 163-191

    7. Molecular Mechanisms of Thyroid Hormone and Retinoic acid Action

      • Magnus Pfahl
      Pages 193-211

  4. Receptor Structure and Associated Proteins

    1. Front Matter

      Pages 213-213
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    2. Heat Shock Proteins and the Cytoplasmic-Nuclear Trafficking of Steroid Receptors

      • William B. Pratt, Lawrence C. Scherrer
      Pages 215-246

    3. In Vitro Assembly of the Avian Progesterone Receptor

      • David F. Smith, William P. Sullivan, Jill Johnson, David O. Toft
      Pages 247-260

    4. Steroid Receptor Associated Proteins: Heat Shock Protein 90 and P59 Immunophilin

      • Marie-Claire Lebeau, Nadine Binart, Françoise Cadepond, Maria-Grazia Catelli, BĂ©atrice Chambraud, Nelly Massol et al.
      Pages 261-280

    5. Estrogenic and Developmental Regulation of 90-Kilodalton Heat Shock Protein Gene Expression

      • G. Shyamala
      Pages 281-305

  5. Receptor Modification and Hormone/Antihormone Interactions

    1. Front Matter

      Pages 305-305
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    2. Phosphorylation and Progesterone Receptor Function

      • Nancy L. Weigel, Angelo Poletti, Candace A. Beck, Dean P. Edwards, Timothy H. Carter, Larry A. Denner
      Pages 309-332

    3. Estrogen Receptor Activation by Ligand-Dependent and Ligand-Independent Pathways

      • Carolyn L. Smith, Orla M. Conneely, Bert W. O’Malley
      Pages 333-356

    4. Why are Steroid Receptor Antagonists Sometimes Agonists?

      • Kathryn B. Horwitz, Kimberly K. Leslie
      Pages 357-375

    5. Ligand Requirements for Estrogen Receptor Function and the Actions of Antiestrogens

      • Joseph C. Reese, Benita S. Katzenellenbogen
      Pages 377-404
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Keywords

About this book

The past few years have witnessed the emergence of steroid hormones as the wonder molecules which generate as much discussion in the scientific literature as they do in a typical living room. This transition has been a result of the tremendous public and scientific interest in the normal functioning of the hor­ mones as well their suggested involvement in several clinical conditions. In the recent past, notable scientific and technological advances have been made in the areas of contraception and regulation of fertility. Steroid receptors are the indis­ pensable mediators of hormonal responses and are complex protein molecules which appear to exist in association with other, yet undefined, proteins and/or factors. Receptors for vitamin D, retinoic acid and the thyroid hormones share structural similarities with steroid receptors, and the roster of this superfamily is still expanding. While our knowledge of the diversity and magnitude of steroid effects has advanced, the precise mode of steroid hormone action has alluded investigators. This volume brings together an international team of prominent investigators who discuss their most recent work on the basic and clinical aspects of steroid/nuclear receptors. The contributions represent updated versions of the invited presentations made at The Second Meadow Brook Conference on Steroid Receptors in Health and Disease. I am grateful to my colleagues on the Scientific Committee: Etienne Baulieu, Jack Gorski, Benita Katzenellenbogen, David Toft and James WittJiff, who provided the vision and guidance in formulating an out­ standing program.

Editors and Affiliations

  • Department of Biological Sciences, Oakland University, Rochester, USA

    V. K. Moudgil

Bibliographic Information

  • Book Title: Steroid Hormone Receptors: Basic and Clinical Aspects

  • Editors: V. K. Moudgil

  • Series Title: Hormones in Health and Disease

  • DOI: https://doi.org/10.1007/978-1-4615-9849-7

  • Publisher: Birkhäuser Boston, MA

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1994

  • Softcover ISBN: 978-1-4615-9851-0Published: 25 November 2012

  • eBook ISBN: 978-1-4615-9849-7Published: 13 March 2013

  • Edition Number: 1

  • Number of Pages: XIV, 522

  • Number of Illustrations: 75 b/w illustrations

  • Topics: General Practice / Family Medicine

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