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Oxygen Free Radicals in Tissue Damage

  • Book
  • © 1993

Overview

Editors:
  1. Merrill Tarr

    1. Dept. of Physiology, University of Kansas Medical Ctr., Kansas City, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Fred Samson

    1. Ralph L. Smith Research Center, University of Kansas Medical Ctr., Kansas City, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-x
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  2. Getting Along With Oxygen

    • Irwin Fridovich
    Pages 1-11

  3. Oxygen Free Radicals and Tissue Injury

    • Donald C. Borg
    Pages 12-53

  4. Photosensitizers as Model Systems to Study Reactive Oxygen Effects in Biological Preparations

    • Dennis P. Valenzeno, Merrill Tarr
    Pages 54-76

  5. Singlet Oxygen in Biological Systems: A Comparison of Biochemical and Photochemical Mechanisms for Singlet Oxygen Generation

    • Jeffrey R. Kanofsky
    Pages 77-92

  6. In Vivo Detection of Oxygen Free Radical Species

    • Robert A. Floyd
    Pages 93-104

  7. Reactive Oxidant Species in Rat Brain Extracellular Fluid

    • Matthew E. Layton, Thomas L. Pazdernik
    Pages 105-131

  8. Oxygen Radicals Mediate Ischemia-Reperfusion-Induced Leukocyte-Endothelial Cell Adhesive Interactions

    • Norman R. Harris, Barbara J. Zimmerman, D. Neil Granger
    Pages 132-146

  9. The Respiratory Burst and Drug Metabolism: Implications for Idiosyncratic Drug Reactions and Antiinflammatory Effects

    • Jack P. Uetrecht
    Pages 147-154

  10. Role of Oxygen Radicals in Central Nervous System Trauma

    • Edward D. Hall
    Pages 155-173

  11. Nitric Oxide as a Mediator of Cerebral Blood-Flow, Synaptic Plasticity, and Superoxide-Mediated Brain Injury

    • Joseph S. Beckman, Jun Chen, Harry Ischiropoulos, Ling Zhu, Karl A. Conger, James H. Halsey Jr
    Pages 174-195

  12. Contributions of the Physical Properties of Neuroprotective Agents to their Efficacy as Inhibitors of Lipid Peroxidation

    • Kenneth L. Audus
    Pages 196-210

  13. Oxidative Stress in the Pathogenesis of Postischemic Ventricular Dysfunction (Myocardial “Stunning”)

    • Marcel Zughaib, Xiao Ying Li, Mohamed O. Jeroudi, Craig J. Hartley, Roberto Bolli
    Pages 211-249

  14. Oxygen Free Radicals in the Pathophysiology of Myocardial Ischemia/Reperfusion

    • James N. Weiss, Joshua I. Goldhaber, Sen Ji
    Pages 250-266

  15. Reactive Oxygen-Induced Modifications of Cardiac Electrophysiology: A Comparison of the Effects of Rose Bengal and other Reactive Oxygen Generators

    • Merrill Tarr, Dennis P. Valenzeno
    Pages 267-284

  16. Back Matter

    Pages 285-297
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Keywords

About this book

Oxygen free radicals and other reactive oxygen species are being postulated as causal agents in an increasing number of pathological conditions. Indeed, some investigators are suggesting that highly destructive reactive oxygen species are the final common path lead­ ing to tissue damage following a wide variety of insults including trauma, hypoxia, ischemia, hyperoxia, radiation, some toxins, and even strenuous athletic pursuits. But, as Robert Floyd points out, "Proof of the importance of oxygen free radicals and the oxidative damage they initiate depend on unequivocal evidence for the pres­ ence of free radicals and a clear association of their formation with the induction of the dysfunction of pathological conditions. " Since such proof does not come easily, there have been and will continue to be many controversies regarding the role played by reactive oxygen species in tissue damage. There have been many recent reviews of the chemistry and pos­ sible role of reactive oxygen species in many types of organ dys­ functions, tissue damage, degenerative diseases, and aging. This book is not such a review. Rather it presents for a diverse audience of physical-organic chemists, biochemists, medical researchers, and other investigators of pathophysiology, discussions of a variety of is­ sues important for understanding reactive oxygen species and their role in tissue damage.

Editors and Affiliations

  • Dept. of Physiology, University of Kansas Medical Ctr., Kansas City, USA

    Merrill Tarr

  • Ralph L. Smith Research Center, University of Kansas Medical Ctr., Kansas City, USA

    Fred Samson

Bibliographic Information

  • Book Title: Oxygen Free Radicals in Tissue Damage

  • Editors: Merrill Tarr, Fred Samson

  • DOI: https://doi.org/10.1007/978-1-4615-9840-4

  • Publisher: Birkhäuser Boston, MA

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1993

  • Softcover ISBN: 978-1-4615-9842-8Published: 26 May 2013

  • eBook ISBN: 978-1-4615-9840-4Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: X, 297

  • Topics: Cell Biology, Science, Humanities and Social Sciences, multidisciplinary

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