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Human Apolipoprotein Mutants 2

From Gene Structure to Phenotypic Expression

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  • © 1989
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Overview

Editors:
  1. C. R. Sirtori

    1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

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  2. G. Franceschini

    1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

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  3. H. B. Brewer

    1. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA

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  4. G. Assmann

    1. University of Münster, Münster, Federal Republic of Germany

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Part of the book series: NATO Science Series A: (NSSA, volume 167)

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-xii
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  2. Evolution and Control of Gene Expression

    1. Apolipoprotein Genes: Organization, Linkage and Evolution

      • Sotirios K. Karathanasis
      Pages 1-7
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    2. Apolipoprotein Variation: Effect on Plasma Lipid Variability

      • Gerd Utermann
      Pages 9-16
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    3. Expression of Human APO AI, AII and CII Genes in Pro- and Eucaryotic Cells

      • W. Stoffel, E. Binczek, A. Haase, C. Holtfreter
      Pages 17-29
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    4. Cis-Acting Elements and Trans-Acting Factors Involved in Cell Type Specific Expression of the Human Apoliprotein AI Gene

      • U. Seedorf, K. N. Sastry, S. K. Karanthanasis
      Pages 31-38
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    5. Human Apolipoprotein A-I: Studies on Gene Expression and Site-Directed Mutagenesis in E. Coli

      • Marco Soria, Antonella Isacchi, Rolando Lorenzetti, Lucia Monaco, Raffaele Palomba, Paolo Sarmientos
      Pages 39-44
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  3. High Density Lipoproteins and Apo AI-Milano

    1. Apolipoprotein AI-Milano: Mechanisms for the Antiatherogenic Potential

      • Guido Franceschini, Laura Calabresi, Massimo Baio, Alex V. Nichols, Cesare R. Sirtori
      Pages 45-50
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    2. In Vivo Catabolism of Apolipoprotein A-I in Subjects with Familial Hypoalphalipoproteinemia

      • P. Roma, R. E. Gregg, M. Meng, C. Bishop, R. Ronan, L. A. Zech et al.
      Pages 51-57
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    3. Synthesis of Apolipoprotein A-I in the Skeletal Muscle of the Developing Chick

      • S. Calandra, P. Tarugi
      Pages 59-65
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    4. Apolipoprotein-Specific High Density Lipoprotein Populations in Plasma of Carriers of the Apolipoprotein AI-Milano

      • Alex V. Nichols, Marian C. Cheung, Patricia J. Blanche, Elaine L. Gong, Guido Franceschini, Cesare R. Sirtori
      Pages 67-73
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  4. Apolipoprotein B

    1. Apo B Gene Variants are Involved in Determining Serum Cholesterol Levels: Towards Identifying these Variants

      • Philippa Talmud, Richard Houlston, Alison Dunning, Steve Humphries
      Pages 75-80
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    2. Genetic Evidence that the Apolipoprotein Gene is not Involved in Abetalipoproteinemia

      • Philippa J. Talmud, June Lloyd, David Muller, David R. Collins, James Scott, Steve Humphries
      Pages 81-84
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    3. RFLPS of ApoB Gene

      • F. Turturro, J. Heibig, G. C. Ghiselli, A. M. Gotto Jr.
      Pages 85-93
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    4. Apolipoprotein B Genetic Dificiences

      • R. Infante
      Pages 95-108
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  5. Apolipoprotein C-II and C-III

    1. The Molecular Basis of ApoC-II Deficiency

      • S. S. Fojo, U. Beisiegel, A. F. H. Stalenhoef, M. Bojanovski, R. E. Gregg, H. Greten et al.
      Pages 109-119
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    2. Familial Chylomicronemia Due to Mutations in Apolipoprotein CII: Apolipoprotein CII-Toronto and Apolipoprotein CII-St. Michael

      • Philip W. Connelly, Graham F. Maguire, J. Alick Little
      Pages 121-126
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    3. Apolipoprotein C-II Deficiency Syndrome: New Insights into the Molecular Mechanism Leading to the Disease in the Apo C-II Padova Kindred

      • G. Baggio, S. Fojo, C. Gabelli, S. Martini, L. Previato, C. Corti et al.
      Pages 127-136
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    4. Biochemical Aspects and Molecular Study of a Case of Apo CII Deficit

      • G. Pepe, C. Crecchio, A. Tullo, A. M. Mogavero, M. De Tommaso, A. Capurso
      Pages 137-141
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    5. The Molecular Basis of the Defect in Familial Combined Apolipoproteins AI and CIII Deficiency

      • Sotirios K. Karathanasis
      Pages 143-155
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    6. Familial Apolipoprotein A-I, C-III and A-IV Deficiency

      • Jose M. Ordovas, Dianne C. King, Ernst J. Schaefer
      Pages 157-159
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Keywords

About this book

The pleasant community of Limone suI Garda provided outstanding hospitality for a second NATO ARW dealing with apolipoprotein variants, which are natures clues for the discovery of the physiological roles of apolipoproteins in lipoprotein metabolism in normal subjects and patients with specific dyslipoproteinemias. Limone, the site of discovery of the first human apolipoprotein mutant, apoA-I-Milano, provided a brilliant sunny spring venue for more than 50 participants from both sides of the ocean. The attendance at the colorful opening ceremony of the ARW was one of the largest on record. Two members of the Italian government, the Secretaries of Health and the Navy, gave the welcoming addresses. Six television networks, two with national audiences, covered the international workshop. The Limone oracles provided a montage of insights gleamed from the eyes of the clinican, the biochemist, and the molecular biologist. The cumulative information on the molecular defects in lipoprotein metabolism reviewed by this diverse group of investigators provided an ever expanding horizon of new knowledge in this fast moving and some times perplexing field. Clinical vignettes were presented on patients from throughout the world including Canada (Connelly), Turkey (Schmitz), and France (Infante) detailing the clinical sequelae of a defect in a specific apolipoprotein. The clinical importance of Lp(a), a lipoprotein relegated almost to obscurity for many years, has now taken v center stage.

Editors and Affiliations

  • Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    C. R. Sirtori, G. Franceschini

  • National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA

    H. B. Brewer

  • University of Münster, Münster, Federal Republic of Germany

    G. Assmann

Bibliographic Information

  • Book Title: Human Apolipoprotein Mutants 2

  • Book Subtitle: From Gene Structure to Phenotypic Expression

  • Editors: C. R. Sirtori, G. Franceschini, H. B. Brewer, G. Assmann

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4615-9549-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1989

  • Softcover ISBN: 978-1-4615-9551-9Published: 30 April 2013

  • eBook ISBN: 978-1-4615-9549-6Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: XII, 255

  • Number of Illustrations: 89 b/w illustrations

  • Topics: Biochemistry, general, Protein Science

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