Living Together

1. Front Matter

   Pages i-viii

   PDF

2. Introduction

   • William Trager

   Pages 1-27

3. The Establishment of Infection

   • William Trager

   Pages 29-39

4. Site Selection within the Host: Entry into Specific Organs and Cells

   • William Trager

   Pages 41-69

5. The Host-Parasite Interface I

   • William Trager

   Pages 71-79

6. The Host-Parasite Interface II

   • William Trager

   Pages 81-95

7. The Uptake of Nutrients. Digestion

   • William Trager

   Pages 97-107

8. Nutritional Requirements

   • William Trager

   Pages 109-119

9. Cultivation of Parasites in Vitro with Special Reference to Differentiation in the Life Cycle

   • William Trager

   Pages 121-146

10. Metabolism

    • William Trager

    Pages 147-169

11. Genetics. Developmental Biology

    • William Trager

    Pages 171-184

12. The Kinetoplast and Kinetoplast DNA

    • William Trager

    Pages 185-199

13. Parasite-Induced Modifications of the Host

    • William Trager

    Pages 201-208

14. Modification of Host Cells Produced by Intracellular Protozoa

    • William Trager

    Pages 209-226

15. Innate Resistance

    • William Trager

    Pages 227-237

16. The Spleen

    • William Trager

    Pages 239-246

17. Immunity in Invertebrates

    • William Trager

    Pages 247-252

18. The Immune System of Vertebrates in Relation to Parasitic Infections

    • William Trager

    Pages 253-264

19. Immune Reactions to Trypanosomes and How They Are Evaded. Ablastin. Antigenic Variation

    • William Trager

    Pages 265-279

20. Immunity to Malaria and Related Intracellular Protozoa

    • William Trager

    Pages 281-308

William Trager has been an avid student of parasites for over 50 years at the Rockefeller University. Around the turn of this century, parasitology enjoyed a certain vogue, inspired by colonial responsibilities of the technically ad­ vanced countries, and by the exciting etiological and therapeutic discoveries of Ross, Manson, Ehrlich, and others. For some decades, the Western hemi­ sphere's interest in animal parasites has been eclipsed by concern for bacteria and viruses as agents of transmissible disease. Only very recently, initiatives like the Tropical Disease Research programs of WHO-World Bank-UNDP, and the Great Neglected Disease networks of the Rockefeller and MacArthur Foundations have begun to compensate for the neglect of these problems by United States federal health research agencies. Throughout that period, how­ ever, the Rockefeller Institute (later University) has given high priority to the challenges of parasitism, corresponding during a formidable period with Dr. Trager's own career. The present work then, is a distillation of the insight collected by our principal doyen of parasite biology, informed but by no means confined to his own research. It is addressed to the reader of broad biological interest and training, not to the specialist. The disarmingly unpretentious style makes the work readily accessible to college undergraduates or even to gifted high school students; but do not be deceived thereby, as it has an enormous range of factual information and theoretical insight, familiar to few, but potentially important to most biologists.

• Malaria
• Pathogene
• Protozoa
• antigen
• biology
• ecology
• genetics
• infection
• invertebrates
• metabolism
• nutrition
• parasite
• parasites
• parasitology
• virus
• infectious diseases

• The Rockefeller University, New York, USA

  William Trager

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