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Molecular Biology and Pathogenesis of Coronaviruses

  • Book
  • © 1984
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Overview

Editors:
  1. P. J. M. Rottier

    1. State University of Utrecht, Utrecht, The Netherlands

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  2. B. A. M. Zeijst

    1. State University of Utrecht, Utrecht, The Netherlands

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  3. W. J. M. Spaan

    1. State University of Utrecht, Utrecht, The Netherlands

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  4. M. C. Horzinek

    1. State University of Utrecht, Utrecht, The Netherlands

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 173)

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Table of contents (45 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Molecular Biology of Coronaviruses

    1. Overview

      1. Biochemistry of Coronaviruses 1983
        • Brian W. J. Mahy
        Pages 1-10
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    2. Viral Proteins and Maturation

      1. Organization of the IBV Genome
        • David F. Stern, Bartholomew Sefton
        Pages 11-23
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      2. Proteolytic Cleavage of Peplomeric Glycoprotein E2 of MHV Yields Two 90K Subunits and Activates Cell Fusion
        • Lawrence S. Sturman, Kathryn V. Holmes
        Pages 25-35
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      3. Coronavirus Maturation
        • Kathryn V. Holmes, Mark F. Frana, Susan G. Robbins, Lawrence S. Sturman
        Pages 37-52
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      4. <u>In Vitro</u> Assembly of the Murine Coronavirus Membrane Protein E1
        • Peter Rottier, Dorothée Brandenburg, John Armstrong, Ben van der Zeijst, Graham Warren
        Pages 53-64
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      5. Characterization of Viral Proteins Synthesized in 229E Infected Cells and Effect(s) of Inhibition of Glycosylation and Glycoprotein Transport
        • M. C. Kemp, J. C. Hierholzer, A. Harrison, J. S. Burks
        Pages 65-77
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      6. Defective Replication of Porcine Transmissible Gastroenteritis Virus in a Continuous Cell Line
        • D. J. Garwes, Lynne Bountiff, G. C. Millson, Carole J. Elleman
        Pages 79-93
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      7. Structural Characterization of IBV Glycoproteins
        • David Cavanagh
        Pages 95-108
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      8. Use of Monoclonal Antibodies to Assess Antigenic Relationships of Avian Infectious Bronchitis Virus Serotypes in the United States
        • D. B. Snyder, W. W. Marquardt
        Pages 109-113
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      9. Monoclonal Antibodies to the Three Classes of Mouse Hepatitis Virus Strain A59 Proteins
        • Marck J. M. Koolen, Albert D. M. E. Osterhaus, Kees H. J. Siebelink, Marian C. Horzinek, Bernard A. M. van der Zeijst
        Pages 115-116
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      10. Antigenic and Polypeptide Structure of Bovine Enteric Coronavirus as Defined by Monoclonal Antibodies
        • J. F. Vautherot, J. Laporte, M. F. Madelaine, P. Bobulesco, A. Roseto
        Pages 117-132
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      11. Plaque Assay, Polypeptide Composition and Immunochemistry of Feline Infectious Peritonitis Virus and Feline Enteric Coronavirus Isolates
        • John F. Boyle, Niels C. Pedersen, James F. Evermann, Alison J. McKeirnan, Richard L. Ott, John W. Black
        Pages 133-147
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      12. Assembly of 229E Virions in Human Embryonic Lung Fibroblasts and Effects of Inhibition of Glycosylation and Glycoprotein Transport on this Process
        • M. C. Kemp, A. Harrison, J. C. Hierholzer, J. S. Burks
        Pages 149-150
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      13. Amphotericin Inhibits Coronavirus SD, SK and A59 Growth
        • B. L. DeVald, J. C. Gerdes, J. S. Burks, M. C. Kemp
        Pages 151-152
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      14. Electron Lucent Structures Induced by Coronaviruses
        • M. C. Kemp, A. Harrison, J. C. Hierholzer, J. S. Burks
        Pages 153-154
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    3. Virus Specific RNAs: Structure and Replication

      1. Cloning and Sequencing the Nucleocapsid and E1 Genes of Coronavirus
        • John Armstrong, Sjef Smeekens, Willy Spaan, Peter Rottier, Ben van der Zeijst
        Pages 155-162
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      2. Nucleotide Sequencing of Mouse Hepatitis Virus Strain JHM Messenger RNA 7
        • Michael Skinner, Stuart Siddell
        Pages 163-171
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      3. Transcription Strategy of Coronaviruses: Fusion of Non-Contiguous Sequences During mRNA Synthesis
        • Willy Spaan, Hajo Delius, Mike A. Skinner, John Armstrong, Pete Rottier, Sjef Smeekens et al.
        Pages 173-186
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      4. Studies on the Mechanism of RNA Synthesis of a Murine Coronavirus
        • Michael M. C. Lai, Ralph S. Baric, Peter R. Brayton, Stephen A. Stohlman
        Pages 187-200
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Keywords

About this book

The present volume contains the Proceedings of an EMBO Workshop organized in June 1983 by the Institute of Virology, Veterinary Faculty, State University of Utrecht, The Netherlands. Some 70 scientists from 11 countries followed the invitation to present and discuss their recent data on the structure, replication, genetics and pathogenesis of coronaviruses. It was the second international meeting on these viruses; the Workshop, which was held in Zeist near Utrecht followed the example of the Wuerzburg symposium of October 1980. At that time it became clear that coronaviruses are unique in many respects. Once a group of viruses that were defined merely on the basis of their characteristic peplomer morphology, Coronaviridae family members are known today - to be constructed from essentially three polypeptides - to use a "nested set" of 5-6 subgenomic mRNAs in the expression of their large, positive and single stranded RNA genome, - to generate these subgenomic RNAs through specific fusion of non­ contiguous sequences, - to mature by budding from intracellular membranes, - to cause persistent infection with neurological involvement and sometimes immunopathological conditons. These and many other findings have been established only very recently. The articles collected in this book reveal and/or further detail these findings. Since these Proceedings contain the combined scientific presentations of representatives from virtually all laboratories engaged in the field, they provide a fairly comprehensive review of the state of the art in corona­ virology.

Editors and Affiliations

  • State University of Utrecht, Utrecht, The Netherlands

    P. J. M. Rottier, B. A. M. Zeijst, W. J. M. Spaan, M. C. Horzinek

Bibliographic Information

  • Book Title: Molecular Biology and Pathogenesis of Coronaviruses

  • Editors: P. J. M. Rottier, B. A. M. Zeijst, W. J. M. Spaan, M. C. Horzinek

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-9373-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1984

  • Softcover ISBN: 978-1-4615-9375-1Published: 25 November 2012

  • eBook ISBN: 978-1-4615-9373-7Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 409

  • Topics: Medical Microbiology

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