PROTEASES: Potential Role in Health and Disease

1. Front Matter

   Pages i-xv

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2. Physiology and Pathophysiology of Proteases and their Inhibitors

   1. Physiology and Pathophysiology of Neutral Proteinases of Human Granulocytes

      • Klaus Havemann, Margarethe Gramse

      Pages 1-20

   2. Regulation of Protease Activity

      • Marion Steinbuch

      Pages 21-40

   3. Human Kininogens and their Function in the Kallikrein-Kinin Systems

      • Werner Müller-Esterl, Hans Fritz

      Pages 41-62

   4. Possible Involvement of Kinins in Muscle Energy Metabolism

      • G. Dietze, E. Maerker, C. Lodri, R. Schifman, M. Wicklmayr, R. Geiger et al.

      Pages 63-71

   5. Structure and Function of Natural Inhibitors as Antagonists of Proteinase Activities

      • Harald Tschesche

      Pages 73-87

   6. Oxidation of Alpha-1-Proteinase Inhibitor: Significance for Pathobiology

      • James Travis, Keith Beatty, Nancy Matheson

      Pages 89-95

   7. In Vivo Significance of Kinetic Constants of Macromolecular Proteinase Inhibitors

      • Joseph G. Bieth

      Pages 97-109

   8. On the Multiplicity of Cellular Elastases and their Inefficient Control by Natural Inhibitors

      • W. Hornebeck, D. Brechemier, M. P. Jacob, C. Frances, L. Robert

      Pages 111-119

   9. Proteases - Proteases Inhibitors: A Local Cellular Information System

      • Hartmut Heine

      Pages 121-127

3. Proteases and Hormones

   1. Regulatory Proteolysis during Corticosteroid Hormone Action

      • M. K. Agarwal

      Pages 129-140

   2. Proteases in Hormone Production and Metabolism

      • Willa A. Hsueh

      Pages 141-151

   3. Precursor Processing and Metabolism of Parathyroid Hormone: Regulation by Calcium

      • Jan A. Fischer

      Pages 153-164

   4. Processing and Degradation of Met-Enkephalin by Peptidases Associated with Rat Brain Cortical Synaptosomes

      • Wolfgang Demmer, Karl Brand

      Pages 165-177

4. Proteases in Kidney and Intestinal Tract

   1. Characterization and Clinical Significance of Membrane Bound Proteases from Human Kidney Cortex

      • J. Scherberich, C. Gauhl, G. Heinert, W. Mondorf, W. Schoeppe

      Pages 179-190

   2. Recent Advances in Protease Research using Synthetic Substrates

      • Reinhart Gossrau, Zdenek Lojda, Robert E. Smith, Pranav Sinha

      Pages 191-207

   3. Kinetic Characterization of Brush Border Membrane Proteases in Relationship to Mucosal Architecture by Section Biochemistry

      • Siegfried Gutschmidt, Rüdiger Hoper, Reinhart Gossrau

      Pages 209-218

   4. Fluorescence Detection of Proteases with AFC, AMC and MNA Peptides using Isoelectric Focusing

      • Pranav Sinha, Reinhart Gossrau, Robert E. Smith, Zdenek Lojda

      Pages 219-226

5. Proteases and Blood System

   1. Pathophysiology of the Interaction between Complement and Non-Complement Proteases

      • U. E. Nydegger, S. Suter

      Pages 227-234

   2. Interactions between the Alternative Complement Pathway and Proteases of the Coagulation System

      • M. D. Kazatchkine, M.-H. Jouvin

      Pages 235-239

We are pleased to present to our readers the Proceedings of the International Symposium "Proteases: Potential Role in Health and Disease" which was held in WUrzburg (FRG) during October 17-20, 1982. The topics discussed included those dealing with the physi­ ology and pathophysiology of proteases and their inhibitors, the interactions of proteases and hormones, the kallikrein-kinin system, complement and the coagulation system, the function of proteases in the kidney and the intestinal tract as well as the role of proteases in lung diseases, pancreatitis, arthritis and hypercatabolic states (multiple trauma, septicemia, acute renal failure). The papers presented answered many questions, but raised many more concerning the significance of proteases and their inhibitors in clinical medicine. It was unfortunately impossible in this volume to in­ clude the extended, lively and extremely stimulating discussions which were enjoyed by the participants during the conference. The meeting has provided a unique framework for close inter­ action between scientists from various disciplines, including bio­ chemistry, physiology, surgery, anaesthesiology, endocrinology, hematology, pulmonology and nephrology. We would like to express our thanks and appreciation for all those who have stimulated, encouraged and supported us to hold this symposium in WUrzburg. This endeavor could not have been possible without the generous financial support of the Paul-Martini­ Foundation (Mainz), Bayer AG (Leverkusen), Beiersdorf AG (Hamburg).

• Calcium
• DNA
• Oxidation
• RNA
• amino acid
• biochemistry
• chemistry
• endocrinology
• enzymes
• hematology
• kidney
• metabolism
• physiology
• protein
• receptor

• University of Würzburg, Würzburg, Federal Republic of Germany

  Walter H. Hörl, August Heidland

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