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Chemical Mutagens

Principles and Methods for Their Detection Volume 3

  • Book
  • © 1973

Overview

Editors:
  1. Alexander Hollaender

    1. Biology Division, Oak Ridge National Laboratory, Oak Ridge, USA
      University of Tennessee, Knoxville, USA

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xxii
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  2. History of Research on Chemical Mutagenesis

    • C. Auerbach
    Pages 1-19

  3. Observations on Meiotic Chromosomes of the Male Mouse as a Test of the Potential Mutagenicity of Chemicals in Mammals

    • Alain Léonard
    Pages 21-56

  4. Techniques for Monitoring and Assessing the Significance of Mutagenesis in Human Populations

    • Howard B. Newcombe
    Pages 57-77

  5. Specific-Locus Mutational Assay Systems for Mouse Lymphoma Cells

    • Donald Clive, W. Gary Flamm, James B. Patterson
    Pages 79-103

  6. Approaches to Monitoring Human Populations for Mutation Rates and Genetic Disease

    • J. V. Neel, T. O. Tiffany, N. G. Anderson
    Pages 105-150

  7. Repair of Chemical Damage to Human DNA

    • James D. Regan, R. B. Setlow
    Pages 151-170

  8. Tradescantia Stamen Hairs: A Radiobiological Test System Applicable to Chemical Mutagenesis

    • A. G. Underbrink, L. A. Schairer, A. H. Sparrow
    Pages 171-207

  9. Detection of Genetically Active Chemicals Using Various Yeast Systems

    • Friedrich K. Zimmermann
    Pages 209-239

  10. Total Reproductive Capacity in Female Mice: Chemical Effects and Their Analysis

    • W. M. Generoso, G. E. Cosgrove
    Pages 241-258

  11. Insect Chemosterilants as Mutagens

    • Alexej B. BoÅ™kovec
    Pages 259-270

  12. The Literature of Chemical Mutagenesis

    • John S. Wassom
    Pages 271-287

  13. Back Matter

    Pages 289-304
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Keywords

About this book

The ready acceptance and wide demand for copies of the first two volumes of Chemical Mutagens: Principles and Methods Jar Their Detection have demon­ strated the need for wider dissemination of information on this timely and urgent subject. Therefore, it was imperative that a third volume be prepared to include more detailed discussions on techniques of some of the methods that were presented from a theoretical point of view in the first two volumes, and to update this rapidly expanding field with current findings and the new developments that have taken place in the past three years. Also included is a special chapter by Dr. Charlotte Auerbach giving the historical background of the discovery of chemical mutagenesis. Methods for recognizing mutagenic compounds in vitro are a necessary preliminary step toward arriving at satisfactory solutions for recognizing significant mutation rates in man, which must be done before our test­ tube methods of detection can be considered reliable. Two chapters in this volume make important contributions to this problem. Due to the increasing activity in efforts to perfect techniques for detecting chemical mutagens and their effects on man, it is planned to continue this series of volumes as necessary to keep abreast of current findings.

Editors and Affiliations

  • Biology Division, Oak Ridge National Laboratory, Oak Ridge, USA

    Alexander Hollaender

  • University of Tennessee, Knoxville, USA

    Alexander Hollaender

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