Skip to main content
SpringerLink
Log in
Book cover

Chemical Mutagens

Principles and Methods for Their Detection: Volume 2

  • Book
  • © 1971

Overview

Editors:
  1. Alexander Hollaender

    1. Division of Biology, Oak Ridge National Laboratory, Oak Ridge, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (14 chapters)

  1. Front Matter

    Pages i-xxii
    Download chapter PDF

  2. Measurement of Recessive Lethal Damage Over the Entire Genome and at Two Specific Loci in the ad-3 Region of a Two-Component Heterokaryon of Neurospora crassa

    • F. J. de Serres, H. V. Malling
    Pages 311-342

  3. Aspergillus

    • J. A. Roper
    Pages 343-363

  4. Higher Plants

    • L. Ehrenberg
    Pages 365-386

  5. Procedures for Culturing Diploid Cells and Preparation of Meiotic Chromosomes from Dwarf Species of Hamsters

    • G. Yerganian, K. S. Lavappa
    Pages 387-410

  6. Induction and Analysis of Gene Mutations in Mammalian Cells in Culture

    • Ernest H. Y. Chu
    Pages 411-444

  7. Inducing Mutations with Chemicals in Habrobracon

    • Roger H. Smith, R. C. von Borstel
    Pages 445-460

  8. The Detection of Mutations in Drosophila melanogaster

    • S. Abrahamson, E. B. Lewis
    Pages 461-487

  9. Root Tips for Studying the Effects of Chemicals on Chromosomes

    • B. A. Kihlman
    Pages 489-514

  10. Cytogenetic Studies in Animals

    • Maimon M. Cohen, Kurt Hirschhorn
    Pages 515-534

  11. Specific Locus Mutation in Mice

    • B. M. Cattanach
    Pages 535-539

  12. Dominant Lethal Mutations in Mammals

    • A. J. Bateman, S. S. Epstein
    Pages 541-568

  13. The Host-Mediated Assay, a Practical Procedure for Evaluating Potential Mutagenic Agents in Mammals

    • M. S. Legator, H. V. Malling
    Pages 569-589

  14. Human Population Monitoring

    • James F. Crow
    Pages 591-605

  15. Conclusion

    • Alexander Hollaender
    Pages 607-610

  16. Back Matter

    Pages 611-650
    Download chapter PDF
Back to top

Keywords

About this book

The best protection against environmental mutagens is to identify them before they ever come into general use. But it is always possible that some substance will escape detection and affect a large number of persons without this being realized until later generations. This article considers ways in which such a genetic emergency might be promptly detected. A mutation-detecting system should be relevant in that it tests for effects that are as closely related as possible to those that are feared. It should be sensitive enough to detect a moderate increase in mutation rate, able to discover the increase promptly before more damage is done, responsive to various kinds of mutational events, and designed in such a way as to maxi­ mize the probability that the Gause of an increase can be found. Methods based on germinal mutation necessarily involve enormous numbers of persons and tests. On the other hand, with somatic mutations the individual cell becomes the unit of measurement rather than the in­ dividual person. For this reason, I think that somatic tests are preferable to germinal tests, despite the fact that it is germinal mutations which are feared.

Editors and Affiliations

  • Division of Biology, Oak Ridge National Laboratory, Oak Ridge, USA

    Alexander Hollaender

Bibliographic Information

  • Book Title: Chemical Mutagens

  • Book Subtitle: Principles and Methods for Their Detection: Volume 2

  • Editors: Alexander Hollaender

  • DOI: https://doi.org/10.1007/978-1-4615-8969-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1971

  • Softcover ISBN: 978-1-4615-8971-6Published: 10 September 2012

  • eBook ISBN: 978-1-4615-8969-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXII, 342

  • Topics: Human Genetics, Bioorganic Chemistry, Veterinary Medicine/Veterinary Science

Publish with us

Policies and ethics

Back to top

Search

Navigation