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Regulation of Cell Proliferation and Differentiation

  • Book
  • © 1977

Overview

Editors:
  1. Warren W. Nichols

    1. Institute for Medical Research, Camden, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Donald G. Murphy

    1. National Institute on Aging, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cellular Senescence and Somatic Cell Genetics (CSSCG)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xii
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  2. Clinical Overgrowth, Undergrowth, and Failure to Thrive

    1. Dysplasia, Malformations and Cancer, Especially with Respect to the Wiedemann-Beckwith Syndrome

      • Jürgen Herrmann, Enid F. Gilbert, John M. Opitz
      Pages 1-64

    2. Delayed Mutation as a Cause of Genetic Disease in Man: Achondroplasia and the Wiedemann-Beckwith Syndrome

      • Jürgen Herrmann, John M. Opitz
      Pages 65-79

    3. Undergrowth Disorders

      • David W. Smith
      Pages 81-85

  3. Cellular Regulation in Cell Proliferation In vitro

    1. A Review of Controversial Issues in Myogenesis

      • H. Holtzer, G. Yeoh, N. Rubinstein, J. Chi, S. Fellini, S. Dienstman
      Pages 87-104

    2. The Culture Environment and Its Control of Myogenesis

      • Irwin R. Konigsberg
      Pages 105-137

    3. Fusion, Phospholipase C, and Myogenesis

      • Mark Nameroff
      Pages 139-142

  4. Molecular Studies in Regulation of Cell Proliferation

    1. Application of Clonal Assay Methods to the Analysis of Tissue Development and Diseased States

      • Stephen D. Hauschka
      Pages 143-164

    2. Proliferative Growth during Myogenesis In Vitro

      • Frank E. Stockdale
      Pages 165-176

    3. Cell Fusion and Terminal Differentiation in Myogenic Cell Cultures

      • Richard C. Strohman, Paul Moss
      Pages 177-196

  5. Back Matter

    Pages 197-204
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Keywords

About this book

In 1974 The National Institute on Aging established a somatic cell genetic resource for aging research at the Institute for Medical Research in Camden, New Jersey. Within this program there is a yearly workshop to promote theory and concept develop­ ment in aging research with the specific purpose of addressing the use of genetically marked cells for aging research and to stimulate interest in aging research by workers in a variety of disciplines. This monograph, The Regulation of Cell Proliferation and Differentiation, is the result of the first workshop held May 15-17, 1975. The concept of the workshop was to consider two main areas: First, a discussion of clinical syndromes expressing as a major manifestation excessive growth, deficient growth or failure to thrive; and second, to present work in cellular and molecular biology on a model system suitable for in vitro study of regulation of cell proliferation and diff2rentiation. The model selected for this was skeletal muscle. It has been widely accepted that normal somatic cells from individual human donors display limited replicative lifespans when cultivated in vitro (1,2). That such "clonal senescence" may be related to in vivo aging is suggested by observations relating the replicative lifespans of cultures to donor age (3-5,13) donor genotype (4-7) and donor's tissue of origin (5,8). A variety of theories have been developed to explain in vitro clonal senescence (9).

Editors and Affiliations

  • Institute for Medical Research, Camden, USA

    Warren W. Nichols

  • National Institute on Aging, Bethesda, USA

    Donald G. Murphy

Bibliographic Information

  • Book Title: Regulation of Cell Proliferation and Differentiation

  • Editors: Warren W. Nichols, Donald G. Murphy

  • Series Title: Cellular Senescence and Somatic Cell Genetics

  • DOI: https://doi.org/10.1007/978-1-4615-8846-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1977

  • Softcover ISBN: 978-1-4615-8848-1Published: 27 December 2012

  • eBook ISBN: 978-1-4615-8846-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 204

  • Topics: Anatomy

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