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Ribosomes

  • Book
  • © 1999

Overview

Authors:
  1. Alexander S. Spirin

    1. Russian Academy of Sciences, Moscow, Russia

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Part of the book series: Cellular Organelles (CORG)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xv
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  2. Historical and Fundamental Introduction

    1. Front Matter

      Pages 1-1
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    2. Protein Biosynthesis

      • Alexander S. Spirin
      Pages 3-5

    3. Messenger RNA and the Genetic Code

      • Alexander S. Spirin
      Pages 7-22

    4. Transfer RNA and Aminoacyl-tRNA Synthetases

      • Alexander S. Spirin
      Pages 23-45

    5. Ribosomes and Translation

      • Alexander S. Spirin
      Pages 47-60

  3. Structure of the Ribosome

    1. Front Matter

      Pages 61-61
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    2. Morphology of the Ribosome

      • Victor D. Vasiliev
      Pages 63-73

    3. Ribosomal RNA

      • Alexey A. Bogdanov
      Pages 75-95

    4. Ribosomal Proteins

      • Alexander S. Spirin
      Pages 97-116

    5. Mutual Arrangement of Ribosomal RNA and Proteins (Quaternary Structure)

      • Alexander S. Spirin
      Pages 117-129

  4. Function of the Ribosome

    1. Front Matter

      Pages 131-131
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    2. Functional Activities and Functional Sites of the Ribosome

      • Alexander S. Spirin
      Pages 133-161

    3. Elongation Cycle, Step I: Aminoacyl-tRNA Binding

      • Alexander S. Spirin
      Pages 163-193

    4. Elongation Cycle, Step II: Transpeptidation (Peptide Bond Formation)

      • Alexander S. Spirin
      Pages 195-211

    5. Elongation Cycle, Step III: Translocation

      • Alexander S. Spirin
      Pages 213-239

    6. Elongation Rate and its Modulation

      • Alexander S. Spirin
      Pages 241-259

    7. Termination of Translation

      • Alexander S. Spirin
      Pages 261-270

    8. Initiation of Translation

      • Alexander S. Spirin
      Pages 271-308

    9. Translational Control in Prokaryotes

      • Alexander S. Spirin
      Pages 309-338
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Keywords

About this book

This book is based on an advanced course of lectures on ribosome structure and protein biosynthesis that I offer at the Moscow State University. These lectures have been part of a general course on molecular biology for almost three decades, and they have undergone considerable evolution as knowledge has been pro­ gressing in this field. The progress continues, and readers should be prepared that some facts, statements, and ideas included in the book may be incomplete or out­ of-date. In any case, this is primarily a textbook, but not a comprehensive review. It provides a background of knowledge and current ideas in the field and gives ex­ amples of observations and their interpretations. I understand that some interpre­ tations and generalizations may be tentative or disputable, but I hope that this will stimulate thinking and discussing better than if I left white spots. The book has a prototype: it is my monograph "Ribosome Structure and Pro­ tein Biosynthesis" published by the Benjamin/Cummings Publishing Company, Menlo Park, California, in 1986. Here I have basically kept the former order of pre­ sentation ofthe topics and the subdivision into chapters. The contents ofthe chap­ ters, however, have been significantly revised and supplemented. The newly writ­ ten chapters on translational control in prokaryotes (Chapter 16) and eukaryotes (Chapter 17) are added.

Authors and Affiliations

  • Russian Academy of Sciences, Moscow, Russia

    Alexander S. Spirin

Bibliographic Information

  • Book Title: Ribosomes

  • Authors: Alexander S. Spirin

  • Series Title: Cellular Organelles

  • DOI: https://doi.org/10.1007/978-1-4615-7817-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • Softcover ISBN: 978-0-306-46146-0Published: 23 March 2000

  • eBook ISBN: 978-1-4615-7817-8Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: XV, 416

  • Topics: Biochemistry, general

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