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Research Methods in Neurochemistry

Volume 1

  • Book
  • © 1972

Overview

Editors:
  1. Neville Marks

    1. New York State Research Institute, Neurochemistry and Drug Addiction, New York, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Richard Rodnight

    1. Department of Biochemistry, Institute Psychiatry, University of London, London, Great Britain

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Ultrastructure and Fragmentation of Neural Tissues

    1. Front Matter

      Pages 1-1
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    2. Nervous System Cell Preparations: Microdissection and Micromanipulation

      • Betty I. Roots, Patricia V. Johnston
      Pages 3-17

    3. The Bulk Separation of Neuroglia and Neuron Perikarya

      • Shirley E. Poduslo, William T. Norton
      Pages 19-32

    4. Separation of Myelin Fragments from the Central Nervous System

      • Martha Spohn, Alan N. Davison
      Pages 33-43

    5. Principles for the Optimization of Centrifugation Conditions for Fractionation of Brain Tissue

      • Carl W. Cotman
      Pages 45-93

    6. Brain Ribosomes

      • Claire E. Zomzely-Neurath, Sidney Roberts
      Pages 95-137

    7. Isolation of Brain Cell Nuclei

      • Bruce S. McEwen, Richard E. Zigmond
      Pages 139-161

  3. Properties of Intact Neural Tissues

    1. Front Matter

      Pages 163-163
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    2. Ventriculocisternal Perfusion as a Technique for Studying Transport and Metabolism Within the Brain

      • Joseph D. Fenstermacher
      Pages 165-178

    3. The Estimation of Extracellular Space of Brain Tissue in Vitro

      • Stephen R. Cohen
      Pages 179-219

  4. Components of Neural Tissues

    1. Front Matter

      Pages 221-221
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    2. Ethanolamine Plasmalogens

      • Lloyd A. Horrocks, Grace Y. Sun
      Pages 223-231

    3. Methods for Separation and Determination of Gangliosides

      • L. S. Wolfe
      Pages 233-248

    4. Mucopolysaccharides and Glycoproteins

      • Richard U. Margolis, Renée K. Margolis
      Pages 249-284

  5. Biologically Active Amines

    1. Front Matter

      Pages 285-285
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    2. Assay of Biogenic Amines and Their Deaminating Enzymes in Animal Tissues

      • Solomon H. Snyder, Kenneth M. Taylor
      Pages 287-315

    3. Enzymes Involved in the Catalysis of Catecholamine Biosynthesis

      • M. Goldstein
      Pages 317-340

    4. Detection and Quantitative Analysis of Some Noncatecholic Primary Aromatic Amines

      • Alan A. Boulton, John R. Majer
      Pages 341-356

  6. Back Matter

    Pages 357-368
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Keywords

About this book

On picking up this first volume of a new series of books the reader may ask the two questions: (a) why research methods? and (b) why in neurochem­ istry? The answers to these questions are easy - they more than justify the volumes to come and show the strong need for their existence. It is customary to think of methods as a necessary but unexciting means to an end - to relegate advances in methodology to a minor role in the creative, original portion of advances in science. This is not the case; the pace-setting function of methodology is well illustrated in most areas of neurobiology. To formulate our questions to Nature (which is the essence of experimental design), methodology is needed; to get answers to our ques­ tions we have to devise yet new methods. The chapters of the present volume fully illustrate how the development of a new method can cut a new path­ how it can open new fields, just as the microscope founded histology. Heter­ ogeneity of structures presents a formidable challenge for methodology in the nervous system, yet methods for separating the structures are essential if we ever want to decipher the enigma of functional contribution of the ele­ ments to the whole. The problem is not only physical separation-clearly methods are essential to study complex structures in situ.

Editors and Affiliations

  • New York State Research Institute, Neurochemistry and Drug Addiction, New York, USA

    Neville Marks

  • Department of Biochemistry, Institute Psychiatry, University of London, London, Great Britain

    Richard Rodnight

Bibliographic Information

  • Book Title: Research Methods in Neurochemistry

  • Book Subtitle: Volume 1

  • Editors: Neville Marks, Richard Rodnight

  • DOI: https://doi.org/10.1007/978-1-4615-7748-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1972

  • Softcover ISBN: 978-1-4615-7750-8Published: 15 April 2012

  • eBook ISBN: 978-1-4615-7748-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXII, 368

  • Topics: Neurosciences

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