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Purine and Pyrimidine Metabolism in Man VII

Part B: Structural Biochemistry, Pathogenesis, and Metabolism

  • Book
  • © 1991

Overview

Editors:
  1. R. Angus Harkness

    1. Institute of Child Health, London, UK

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  2. Gertrude B. Elion

    1. Burroughs Wellcome Co., Research Triangle Park, USA

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  3. Nepomuk Zöllner

    1. Universität München, München, Germany

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 309B)

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Table of contents (87 chapters)

  1. Front Matter

    Pages i-xix
    Download chapter PDF

  2. Structural Biochemistry, Pathogenesis and Metabolism

    1. Measurement of Purine and Pyrimidines in Tissues and Biological Fluids

      1. Capillary Electrophoresis for the Analysis of Cellular Nucleotides
        • David Perrett, Gordon Ross
        Pages 1-5
      2. An Improved Screening Method for Inherited Disorders of Purine and Pyrimidine Metabolism by HPLC
        • P. M. Davies, M. B. McBride, H. A. Simmonds
        Pages 7-10
      3. A Single HPLC System for the Evaluation of Purine and Pyrimidine Metabolites in Body Fluids
        • I. A. Rivera, I. Tavares de Almeida, C. Silveira
        Pages 11-14
      4. Simple Method for the Quantitative Analysis of Dihydropyrimidines and N-Carbamyl-ß-Amino Acids in Urine
        • Albert H. van Gennip, Sandra Busch, Eline G. Scholten, Lida E. Stroomer, Nico G. Abeling
        Pages 15-19
      5. Diagnostic Potential of HPLC: Experimental and Clinical Trials
        • R. T. Toguzov, Yu. V. Tikhonov
        Pages 21-26
      6. Reference Values of Orotic Acid, Uracil and Pseudouridine in Urine
        • Satoru Ohba, Kiyoshi Kidouchi, Chie Nakamura, Toshiyuki Katoh, Masanori Kobayashi, Yoshiro Wada
        Pages 27-30
      7. Automated Quantitative Analysis for Orotidine and Uridine/Thymine in Urine by High-Performance Liquid Chromatography with Column Switching
        • Kiyoshi Kidouchi, Chie Nakamura, Toshiyuki Katoh, Tetsuya Kibe, Satoru Ohba, Yoshiro Wada
        Pages 31-34
      8. HPLC Assay of Uridine Monophosphate Synthase (UMPS) in Chorionic Villus Samples (CVS) and Erythrocytes (RBC)
        • Lynette D. Fairbanks, John A. Duley, Ailsa J. Shores, H. Anne Simmonds
        Pages 35-38
      9. A RP-HPLC Method for the Measurement of Guanine, Other Purine Bases and Nucleosides
        • C. P. Quaratino, E. Messina, P. Bertuglia, G. Spoto, G. Sciarra, G. Bucci et al.
        Pages 39-42
      10. Some Aspects of Purine Nucleotide Metabolism in Human Lymphocytes before and after Infection with HIV-1 Virus: Nucleotide Content
        • Roberto Pagani, Antonella Tabucchi, Filippo Carlucci, Roberto Leoncini, Elena Consolmagno, Massimo Molinelli et al.
        Pages 43-46
      11. Prenatal Diagnosis of Lesch-Nyhan Syndrome by Purine Analysis of Amniotic Fluid and Cordocentesis
        • Felícitas A. Mateos, Juan G. Puig, Teresa H. Ramos, Manuel L. Jiménez, Nuria M. Romera, Antonio G. González
        Pages 47-50

    2. Structural Biochemistry

      1. Gene Therapy in Man and Mice: Adenosine Deaminase Deficiency, Ornithine Transcarbamylase Deficiency, and Duchenne Muscular Dystrophy
        • Markus Grompe, Kohnosuke Mitani, Cheng-Chi Lee, Stephen N. Jones, C. Thomas Caskey
        Pages 51-56
      2. Regulation of the Human Adenosine Deaminase Gene by First Intron Sequences: A T-Cell Enhancer
        • Dan Wiginton, Bruce Aronow, Richard Silbiger, Steven Potter, John Hutton
        Pages 57-60
      3. Expression of the APRT Gene in an Adenovirus Vector System as a Model for Studying Gene Therapy
        • Qing Wang, Vincent Konan, Milton W. Taylor
        Pages 61-66
      4. Transcriptional Regulation of Ribonucleotide Reductase
        • Daniel A. Albert, Enrique Rozengurt
        Pages 67-72
      5. Mutational Basis of Adenine Phosphoribosyltransferase Deficiency
        • Amrik Sahota, Ju Chen, Peter J. Stambrook, Jay A. Tischfield
        Pages 73-76
      6. Analysis of the Promoter Region of the CHO APRT Gene
        • Bin Ru She, Milton W. Taylor
        Pages 77-81
      7. A Splice Mutation at the Adenine Phosphoribosyltransferase Locus Detected in a German Family
        • Birgit S. Gathof, Amrik Sahota, Ursula Gresser, Ju Chen, Peter S. Stambrook, Jay A. Tischfield et al.
        Pages 83-86
      8. Germline and Somatic Mutations Leading to Adenine Phosphoribosyltransferase (APRT) Deficiency
        • Masayuki Hakoda, Naoyuki Kamatani, Sanae Ohtsuka, Sadao Kashiwazaki
        Pages 87-90
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Keywords

About this book

These two volumes record the scientific and clinical work presented at the VIIth International and 3rd European joint symposium on purine and pyrimidine metabolism in man held at the Bournemouth International Conference Centre, Bournemouth, UK, from 30th June to 5th July 1991. The series of international meetings at three yearly intervals have previously been held initially in 1973 in Israel, then Austria, Spain, the Netherlands, USA and Japan. The European Society for the Study of Purine and pyrimidine Metabolism in Man (ESSPPM) which has its own executive and some finance first met in switzerland in 1987, then in Germany in 1989. The steady evolution of the science in this series of meetings is intellectually satisfying; the subsequent clinical progress is emotionally and economically reassuring. As befits the position of purines and pyrimidines at the centre of biochemistry, there has been steady scientific development into molecular genetics and now onto developmental controls and biochemical pharmacology. The complexities of the immune system are being unravelled but an understanding of the human brain largely eludes us. Laboratory based scientists now predominate over those who work as clinical specialists in VIi rheumatology, immunology, oncology and paediatrics. However, there continue to be major clinical objectives since large sections are concerned with major causes of death like ATP depletion, cancer and now AIDS; the laboratory work is providing clinical solutions.

Editors and Affiliations

  • Institute of Child Health, London, UK

    R. Angus Harkness

  • Burroughs Wellcome Co., Research Triangle Park, USA

    Gertrude B. Elion

  • Universität München, München, Germany

    Nepomuk Zöllner

Bibliographic Information

  • Book Title: Purine and Pyrimidine Metabolism in Man VII

  • Book Subtitle: Part B: Structural Biochemistry, Pathogenesis, and Metabolism

  • Editors: R. Angus Harkness, Gertrude B. Elion, Nepomuk Zöllner

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-7703-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1991

  • Softcover ISBN: 978-1-4615-7705-8Published: 14 June 2012

  • eBook ISBN: 978-1-4615-7703-4Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIX, 393

  • Topics: Biochemistry, general

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