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The Bile Acids: Chemistry, Physiology, and Metabolism

Volume 3: Pathophysiology

  • Book
  • © 1976

Overview

Editors:
  1. Padmanabhan P. Nair

    1. Biochemistry Research Division, Department of Medicine, Sinai Hospital of Baltimore, Inc., Baltimore, USA

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  2. David Kritchevsky

    1. The Wistar Institute of Anatomy and Biology, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Bile Acids and Brain

    • Harold J. Nicholas
    Pages 1-15

  3. Tissue Distribution of Bile Acids: Methodology and Quantification

    • Jacqueline Dupont, Suk Yon Oh, Phyllis Janson
    Pages 17-28

  4. Bile-Salt-Protein Interactions

    • P. P. Nair
    Pages 29-52

  5. Bile Acids in Hepato-Biliary Diseases

    • Helmut Greim
    Pages 53-80

  6. Pathophysiology and Dissolution of Cholesterol Gallstones

    • Jay W. Marks, George G. Bonorris, Leslie J. Schoenfield
    Pages 81-113

  7. The Metabolism of Sterols and Bile Acids in Cerebrotendinous Xanthomatosis

    • G. Salen, E. H. Mosbach
    Pages 115-153

  8. Bile Acids and Intestinal Cancer

    • Norman D. Nigro, Robert L. Campbell
    Pages 155-168

  9. Fecal Steroids in the Etiology of Large Bowel Cancer

    • M. J. Hill
    Pages 169-200

  10. Dietary Fiber and Bile Acid Metabolism

    • David Kritchevsky, Jon A. Story
    Pages 201-209

  11. Back Matter

    Pages 211-229
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Keywords

About this book

The first two volumes of this series addressed themselves to the chemistry, physiology, and metabolism of the bile acids. The present volume is devoted to the pathophysiology of bile acids. As the role of bile acids in health and disease is being increasingly recognized, we have chosen for discussion a wide range of topics of current importance. The presence of bile acids in brain tissue and their possible role in demyelinating diseases form the subject of a provocative discussion. As an extension of this theme, the presence and quantification of bile acids in extrahepatic tissues is the subject of one chapter. The pathophysiological implications of bile acids at the macromolecular level is highlighted by a chapter on the influence of bile salts on the activity of various enzymes. The general area of hepatobiliary diseases is discussed in two chapters: one describes changes in bile salt metabolism in liver diseases and the other focuses on cholesterol gallstones and their formation and dissolution. Cerebrotendinous xanthomatosis has been shown to entail a defect in bile acid and sterol metabolism, and this metabolic error is the subject of an illuminating exposition. There is presently a concerted research effort being brought to bear on the causes of colon cancer, and one important aspect of this work centers on bile acid metabolism. Aspects of bile acid metabolism and cancer are the subject of two chapters. And finally, the role of dietary fiber in bile acid metabolism is updated.

Editors and Affiliations

  • Biochemistry Research Division, Department of Medicine, Sinai Hospital of Baltimore, Inc., Baltimore, USA

    Padmanabhan P. Nair

  • The Wistar Institute of Anatomy and Biology, Philadelphia, USA

    David Kritchevsky

Bibliographic Information

  • Book Title: The Bile Acids: Chemistry, Physiology, and Metabolism

  • Book Subtitle: Volume 3: Pathophysiology

  • Editors: Padmanabhan P. Nair, David Kritchevsky

  • DOI: https://doi.org/10.1007/978-1-4615-7563-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1976

  • Softcover ISBN: 978-1-4615-7565-8Published: 12 July 2012

  • eBook ISBN: 978-1-4615-7563-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 230

  • Number of Illustrations: 18 b/w illustrations

  • Topics: Biochemistry, general

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