Overview
- Editors:
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Roger H. Kennett
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University of Pennsylvania School of Medicine, Philadelphia, USA
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Thomas J. McKearn
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University of Pennsylvania School of Medicine, Philadelphia, USA
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Kathleen B. Bechtol
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The Wistar Institute, Philadelphia, USA
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Table of contents (20 chapters)
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Front Matter
Pages i-xxii
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Introduction
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- Dale E. Yelton, David H. Margulies, Betty Diamond, Matthew D. Scharff
Pages 3-17
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- Vincent R. Zurawski Jr., Paul H. Black, Edgar Haber
Pages 19-33
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Analysis of Immunoglobulin Structure and Genetics
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- Brian Clevinger, James Schilling, Rogers Griffith, Daniel Hansburg, Leroy Hood, Joseph Davie
Pages 37-48
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- Kathleen Denis, Roger H. Kennett, Norman Klinman, Christine Molinaro, Linda Sherman
Pages 49-59
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- Hans Hengartner, Tomaso Meo, Edith Müller
Pages 61-71
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Detection and Analysis of Human Gene Products
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- C. A. Slaughter, M. C. Coseo, C. Abrams, M. P. Cancro, H. Harris
Pages 103-120
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- Richard A. Goldsby, Barbara A. Osborne, Edgar G. Engleman
Pages 121-135
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- Ronald Levy, Jeanette Dilley, Sherri Brown, Yehudit Bergman
Pages 137-153
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- Roger H. Kennett, Zdenka L. Jonak, Kathleen B. Bechtol
Pages 155-168
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Monoclonal Antibodies as Probes in the Study of Cellular Differentiation and Immunogenetics
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Front Matter
Pages 169-169
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- Kathleen B. Bechtol, Zdenka L. Jonak, Roger H. Kennett
Pages 171-184
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- Thomas J. McKearn, Dawn E. Smilek, Frank W. Fitch
Pages 219-234
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- Jeffrey A. Ledbetter, James W. Goding, Takeshi Tokuhisa, Leonard A. Herzenberg
Pages 235-249
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- Donald W. Mason, Roger J. Brideau, W. Robert McMaster, Michael Webb, Robert A. H. White, Alan F. Williams
Pages 251-273
About this book
On August 7, 1975, Kohler and Milstein published in Nature (256:495) a report describing "Continuous cultures of fused cells secreting antibody of predefined specificity. " Their report has become a classic and has already had a profound effect on basic and applied research in biology and medicine. By the time the first Workshop on Lymphocyte Hybridomas (Current Topics in Microbiology and Im munology 81, 1978) was held on April 3-5, 1978, in Bethesda, Maryland, investi gators from many laboratories had made hybrids between plasmacytomas and spleen cells from immunized animals and had obtained monoclonal antibodies reacting with a broad variety of antigenic determinants. At the time Kohler and Milstein introduced this new technology, the editors of this volume were involved in the production of antisera against differentiation antigens (K. B. B. ), histocompatibility antigens (T. ]. McK. ), and human tumor associated antigens (R. H. K. ). Because of the potential usefulness of monoclonal antibodies in these areas, we each began production of hybridomas and analysis of the resulting monoclonal reagents. One of the most interesting aspects of participation in the early stages of the development and application of hybrid oma technology has been observing how the implications of the initial observa tions gradually spread first among the practitioners of immunology and immu nogenetics, and then to other areas of the biological sciences, such as developmental biology, biochemistry, human genetics, and cell and tumor biology.
