Issues and Reviews in Teratology

1. Front Matter

   Pages i-xvii

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2. Problems in Human Teratology

   • Hideo Nishimura

   Pages 1-18

3. Teratology

   • Josef Warkany

   Pages 19-31

4. Cytogenetics of Human Reproductive Wastage

   • David H. Carr

   Pages 33-72

5. Twenty Years of Study of the Etiology of Congenital Malformations in Finland

   • Lauri Saxén

   Pages 73-110

6. Genome and Chromosome Mutations Balance Between Appearance and Elimination

   • A. Boué, Pia Gallano, Joëlle Boué, J. L. Serre, J. Feingold

   Pages 111-147

7. Developmental Toxicity and Nonhuman Primates

   • Andrew G. Hendrickx, Pamela E. Binkerd, Jon M. Rowland

   Pages 149-180

8. Teratogenic Risk Assessment

   • James L. Schardein

   Pages 181-214

9. Thalidomide and Embryonic Sensory Peripheral Neuropathy

   • Charles T. Theisen

   Pages 215-249

10. Restorative Growth in Mammalian Embryos

    • Michael H. L. Snow

    Pages 251-284

11. Functional Teratology of the Cardiovascular and Other Organ Systems

    • Casimer T. Grabowski, George P. Daston

    Pages 285-308

12. Searching for the Mechanism of Acetazolamide Teratogenesis

    • Kenneth S. Hirsch, William J. Scott Jr.

    Pages 309-347

13. Back Matter

    Pages 349-354

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Teratology is at once among the oldest and youngest of human preoccupations. Coincident with man's first observations of the stars were his recordings of human and animal deformities. But, such aberrancies must have occurred even earlier, for although it is one of those things-like evolution-that cannot be proven, it is nevertheless indisputable that dysmorphogenesis must have occurred from the time complex forms of life first arose on our planet; and that from the beginnings of human awareness our species was conscious of such happenings. From the earliest recordings of this fascination with the form and meaning of abnormality a tortuous but continuous line extends to modern struggles to understand and control these manifestations. And now, after long occupying an honorable but peripheral place in the halls of philosophical and scientific pursuits, teratology has quite suddenly come to take a prominent position at the hub of a complex crossroads of human concerns. This shift in its fortune has taken several forms. Fetal maldevelopment has become the concern of environmentalists, activists of various persuasions, indus­ trial organizations, government agencies, ethicists, parents-i. e. , individuals and groups whose actions are impelled by apprehension. Such motives are of course not without basis; the trauma of thalidomide left a scar yet raw. For still others­ clinicians, academics, experimentalists-the upsurge in the interest in fetal mal­ development is at a different level, and their pursuits are broad, taking external agents as but one of the causes of defective development.

• anatomy
• chromosome
• cytogenetics
• embryology
• environment
• epidemiology
• genes
• genetics
• morphogenesis
• natural selection
• pathology
• philosophy
• population
• protein
• sex

• Children’s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA

  Harold Kalter

Policies and ethics