Hormones and Cancer

1. Front Matter

   Pages i-ix

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2. The Polynucleotide Binding Sites of Estradiol Receptor Complexes

   • Herbert W. Dickerman, S. Anand Kumar

   Pages 1-18

3. Estrogen Receptor and the Development of Estrogenic Responses in Embryonic Chick Liver

   • Catherine B. Lazier, Susan A. Nadin-Davis, Alex Elbrecht, Marie-Luise Blue, David L. Williams

   Pages 19-38

4. Biochemical and Estrogenic Activity of Some Diethylstilbestrol Metabolites and Analogs in the Mouse Uterus

   • Kenneth S. Korach

   Pages 39-62

5. Etiology of DES-Induced Uterine Tumors in the Syrian Hamster

   • Wendell W. Leavitt, Rawden W. Evans, William J. Hendry III

   Pages 63-86

6. Neonatal Stimulation of the Uterus by Clomiphene, Tamoxifen and Nafoxidine: Relationship to the Development of Reproductive Tract Abnormalities

   • James H. Clark, Sylvia C. Guthrie, Shirley A. McCormack

   Pages 87-98

7. Effect of Estradiol and Progesterone on the Secretory Immune System in the Female Genital Tract

   • Charles R. Wira, David A. Sullivan

   Pages 99-111

8. The Search for Progesterone-Dependent Proteins Secreted by Human Endometrium

   • David T. MacLaughlin, Paul E. Sylvan, George S. Richardson

   Pages 113-131

9. Estrogen Regulation of Growth and Specific Protein Synthesis in Human Breast Cancer Cells in Tissue Culture

   • Dean P. Edwards, David J. Adams, William L. McGuire

   Pages 133-149

10. Regulation of Pituitary Growth and Prolactin Gene Expression by Estrogen

    • Mara E. Lieberman, Richard A. Maurer, Philippa Claude, Julie Wiklund, Nancy Wertz, Jack Gorski

    Pages 151-163

11. Comparative Antioestrogen Action in Experimental Breast Cancer

    • V. Craig Jordan

    Pages 165-178

12. Inhibition of Estrogen Biosynthesis and Regression of Mammary Tumors by Aromatase Inhibitors

    • A. M. H. Brodie, H. J. Brodie, L. Romanoff, J. G. Williams, K. I. H. Williams, J. T. Wu

    Pages 179-190

13. Biologic Activity of the Iodoestrogens and Their Use in Breast Cancer

    • C. Longcope, T. Arunachalam, I. Rafkind, E. Caspi

    Pages 191-210

14. Prolactin and Prolactin Receptor Interactions in Normal and Neoplastic Tissue

    • Paul A. Kelly, Jean Djiane, Lucile Turcot-Lemay

    Pages 211-229

15. Retinoid Binding in Normal and Neoplastic Mammary Tissue

    • Richard C. Moon, Rajendra G. Mehta

    Pages 231-249

16. Feedback Effects of Mammary Gland Tumors on the Host Pituitary Prolactin Cell

    • W. C. Hymer, Arthur Signorella

    Pages 251-286

17. Mammalian Cell Proliferation is Regulated by the Synergistic Actions of Multiple Growth Factors

    • W. J. Pledger, C. A. Hart, W. R. Wharton

    Pages 287-300

18. Defective Steroid Receptors in a Glucocorticoid Resistant Clone of a Human Leukemic Cell Line

    • J. M. Harmon, T. J. Schmidt, E. B. Thompson

    Pages 301-313

19. Deacylcortivazol, a Potent Glucocorticoid with Unusual Structure and Unusual Anti-Leukemic Cell Activity

    • E. B. Thompson, S. S. Simons Jr., J. M. Harmon

    Pages 315-324

20. New Observation on Androgen Action: Androgen Receptor Stabilization and Antisteroid Effects of LHRH Agonists

    • W. Wright, K. Chan, K. Sundaram, C. W. Bardin

    Pages 325-336

The papers in this volume were presented at the Symposium on Hormones and Cancer held March 24-26, 1980, at the Worcester Foundation for Experimental Biology, Shrewsbury, MA. The meeting was organized to review recent advances in basic and clinical research work on hormone-responsive tumors of the reproductive system. The association between protracted hormone action and cancer of the reproductive system is now irrefutable. Yet we still do not know how hormones initiate and promote neoplastic transformation of their target cells. A major effort is cur­ rently being directed at understanding the hormonal regulation of neoplastic cells, especially those arising from the breast, uterus, pituitary gland and prostate. The symposium brought together leading experts whose research is focused on this impor­ tant area of human health. Although many questions remain to be answered by future studies, the material covered in this volume provides an up-to-date overview of the current status of work in this area. The subjects range from the mechanism of hormone action to the treatment of hormone-dependent tumors, and topics include estrogen, progestin, androgen and glucocorticoid action~ hormone receptors~ specific protein responses~ developmental effects of estrogens and antiestrogens~ the DES syndrome~ regu­ lation of the cell cycle~ therapeutic effects of antiestrogens, aromatase inhibitors, iodoestrogens, progestins on estrogen­ dependent tumors~ characterization of retinoid-binding sites~ and the utility of various tumor markers.

• breast cancer
• cancer
• carcinoma
• cell
• endometrium
• etiology
• hormones
• liver
• tumor

• Worcester Foundation for Experimental Biology, Shrewsbury, USA

  Wendell W. Leavitt

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