Genomic Adaptability in Somatic Cell Specialization

1. Front Matter

   Pages i-xiii

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2. Introduction Early Development and Cell Commitment

   • Laurence D. Etkin

   Pages 1-12

3. DNA Gains, Losses, and Rearrangements in Eukaryotes

   • David M. Prescott

   Pages 13-29

4. Fate and Nuclear Localization of Germinal Vesicle Proteins during Embryogenesis

   • Christine Dreyer

   Pages 31-57

5. Genomic Imprinting in the Mouse

   • S. K. Howlett, W. Reik, S. C. Barton, M. L. Norris, M. A. H. Surani

   Pages 59-77

6. Phenotypic Changes in Cell Culture

   • Morgan Harris

   Pages 79-95

7. Developmental Regulation of the Heat-Shock Response

   • Leon W. Browder, Michael Pollock, Robert W. Nickells, John J. Heikkila, Robert S. Winning

   Pages 97-147

8. Transdifferentiation in Animals A Model for Differentiation Control

   • David S. McDevitt

   Pages 149-173

9. Genomic Activation in Differentiated Somatic Cells

   • Marie A. DiBerardino

   Pages 175-198

10. Neoplastic Cells Modulation of the Differentiated State

    • Robert Gilmore McKinnell

    Pages 199-236

11. Back Matter

    Pages 237-242

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I am pleased to include this book as Volume 6 of Developmental Biology: A Comprehensive Synthesis. It has been edited by two of the foremost investiga­ tors in the study of genomic adaptability. lowe a special debt of gratitude to Dr. Marie A. DiBerardino, who developed the concept of the volume. Dr. DiBerar­ dino is also a very active member of the editorial board for this series. Much of the success of this series is due to her valuable advice. This series was established to create comprehensive treatises on specific topics in developmental biology. Such volumes serve a useful role in develop­ mental biology, since it is a very diverse field that receives contributions from a wide variety of disciplines. This series is a meeting ground for the various practitioners of this science, facilitating an integration of heterogeneous infor­ mation on specific topics. Each volume is intended to provide the conceptual basis for a comprehen­ sive understanding of its topic as well as analysis of the key experiments upon which that understanding is based. The specialist in any aspect of developmen­ tal biology should understand the experimental background of the field and be able to place that body of information in context to ascertain where additional research would be fruitful. At that point, the creative process generates new experiments. This series is intended to be a vital link in that process of learning and discovery.

• Embryo
• Imprinting
• development
• developmental biology
• genes
• oogenesis
• phenotype
• tissue

• Department of Physiology and Biochemistry, The Medical College of Pennsylvania, Philadelphia, USA

  Marie A. DiBerardino

• Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, Houston, USA

  Laurence D. Etkin

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