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Chemical Mutagens

Principles and Methods for Their Detection

  • Book
  • © 1982

Overview

Editors:
  1. Frederick J. Serres

    1. National Institute of Environmental Health Science, Research Triangle Park, USA

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  2. Alexander Hollaender

    1. Associated Universities, Inc., USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xxvi
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  2. Effects of Chemicals on Chromosome-Aberration Production in Male and Female Germ Cells

    • Ilse-Dore Adler, J. Grant Brewen
    Pages 1-35

  3. The Use of Immunological Techniques to Detect Cells of Rare Genotype

    • Aftab A. Ansari, H. V. Mailing
    Pages 37-93

  4. Metabolic Activation Systems in Vitro for Carcinogen/Mutagen Screening Tests

    • H. Bartsch, T. Kuroki, M. Roberfroid, C. Malaveille
    Pages 95-161

  5. Microbial Metabolism of Environmental Chemicals to Mutagens and Carcinogens

    • David F. Callen
    Pages 163-188

  6. Short-Term Tests for Chemicals That Promote Aneuploidy

    • A. J. F. Griffiths
    Pages 189-210

  7. Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology

    • Philip E. Hartman
    Pages 211-294

  8. The Relation between Reaction Kinetics and Mutagenic Action of Monofunctional Alkylating Agents in Higher Eukaryotic Systems: Interspecies Comparisons

    • E. Vogel, A. T. Natarajan
    Pages 295-336

  9. The Human Leukocyte Test System

    • Günter Obe, Bernd Beek
    Pages 337-400

  10. The Activation of Chemicals into Mutagens by Green Plants

    • Michael J. Plewa, James M. Gentile
    Pages 401-420

  11. Unscheduled DNA Synthesis in Mammalian Germ Cells—Its Potential Use in Mutagenicity Testing

    • Gary A. Sega, Rene E. Sotomayor
    Pages 421-445

  12. Aspergillus nidulans—An Organism for Detecting a Range of Genetic Damage

    • Barry R. Scott, Etta Käfer
    Pages 447-479

  13. Back Matter

    Pages 481-497
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Keywords

About this book

New developments in the study of environmental mutagens continue to evolve in this rapidly emerging field. In Volume 7 of Chemical Mutagens, we have focused on various new techniques for the detection of genetic damage in somatic cells and germ cells of mammals and the use of lower eukaryotic microorganisms to detect aneuploidy as well as other types of genetic damage. Attention has also been given to the role of in vitro metabolic activation as a mechanism for modifying the genetic effects of different environmental chemicals. In a chapter on compar­ ative mutagenesis, reaction kinetics and their relationship to the mu­ tagenic action of monofunctional alkylating agents in higher eukaryotic organisms are examined. In another chapter, the pharmacology and toxicology of nitrites and nitrates, which are in widespread distribution in the environment, are discussed in detail. The books in this series have provided a mechanism for the publication of many important new developments in the study of the genetic effects of environmental chemicals. This series was launched by Dr. Alexander Hollaender who, beginning in 1971, edited Volumes 1-4 and then coedited Volumes 5-7. The success of his lO-year effort with these volumes is another testimony to Dr. Hollaender's many contri­ butions to the field of environmental mutagenesis. As Dr.

Editors and Affiliations

  • National Institute of Environmental Health Science, Research Triangle Park, USA

    Frederick J. Serres

  • Associated Universities, Inc., USA

    Alexander Hollaender

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