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  • Book
  • © 1982

Etiology: Chemical and Physical Carcinogenesis

Editors:

  1. Frederick F. Becker

    1. Department of Anatomic and Research Pathology, M.D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, USA

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Part of the book series: Cancer, a compresensive treatise (C)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xxii
    PDF

  2. General Concepts

    1. Front Matter

      Pages 1-1
      PDF

    2. Cytogenetics

      • Peter C. Nowell
      Pages 3-46

    3. Genetics: Animal Tumors

      • W. E. Heston
      Pages 47-71

    4. Genetic Influences in Human Tumors

      • Alfred G. Knudson Jr.
      Pages 73-88

    6. Pathogenesis of Plasmacytomas in Mice

      • Michael Potter
      Pages 135-159

    7. Immunocompetence and Malignancy

      • Cornelis J. M. Melief, Robert S. Schwartz
      Pages 161-199

    8. Epidemiologic Approach to Cancer

      • Vincent F. Guinee
      Pages 201-225

  3. Chemical Carcinogenesis

    1. Front Matter

      Pages 227-227
      PDF

    3. Metabolism of Chemical Carcinogens

      • J. H. Weisburger, G. M. Williams
      Pages 241-333

    4. Chemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acids

      • S. Rajalakshmi, Prema M. Rao, D. S. R. Sarma
      Pages 335-409

    5. Some Effects of Carcinogens on Cell Organelles

      • Donald J. Svoboda, Janardan K. Reddy
      Pages 411-449

    7. Sequential Events in Chemical Carcinogenesis

      • Emmanuel Farber
      Pages 485-506

    8. Neoantigen Expression in Chemical Carcinogenesis

      • Robert W. Baldwin, Michael R. Price
      Pages 507-548

  4. Physical Carcinogenesis

    1. Front Matter

      Pages 549-549
      PDF

    3. Biophysical Aspects of Radiation Carcinogenesis

      • Albrecht M. Kellerer, Harald H. Rossi
      Pages 569-616
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About this book

Six years ago when the first edition of this volume appeared as the first of the series, questions were posed in its preface that are as valid today as they were then. In that preface, I proposed the following challenges: (1) We must identify carcinogenic agents, and by an analysis of their "nature," e. g. , structure and physical characteristics, we may better understand their mechanism of action. (2) We must identify crucial interactions between these carcinogens and impor­ tant macromolecules within the cell, distinguishing those which relate to carcinogenesis from those which are extraneous. (3) We must examine the alterations of cell function induced by these reactions, for it is with an understanding of phenotypic variation that we may know why malignant cells escape from normal homeostatic control. (4) Last, and perhaps of greatest importance, we must define malignancy--define those charac­ teristics of cellular activity that permit the malignant cell to compete so effectively with the normal constituent, which ultimately Ieads to such destructive events. Although great strides have been made toward those goals, as evidenced by a number of new chapters and the new information gathered into others, and although the achievement of those goals sometimes appears but a tantalizing experiment away, none have been achieved. For example, several chapters indude descriptions of the progress that has been made toward the development of "quick assays.
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Editors and Affiliations

  • Department of Anatomic and Research Pathology, M.D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, USA

    Frederick F. Becker

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Bibliographic Information

  • Book Title: Etiology: Chemical and Physical Carcinogenesis

  • Editors: Frederick F. Becker

  • Series Title: Cancer, a compresensive treatise

  • DOI: https://doi.org/10.1007/978-1-4615-6598-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1982

  • Softcover ISBN: 978-1-4615-6600-7Published: 27 December 2013

  • eBook ISBN: 978-1-4615-6598-7Published: 12 June 2019

  • Edition Number: 1

  • Number of Pages: XXII, 714

  • Number of Illustrations: 32 b/w illustrations

  • Topics: Cancer Research, Oncology

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Buy it now

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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