Anticarcinogenesis and Radiation Protection

1. Front Matter

   Pages i-xiv

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2. Free Radical Mechanisms

   1. The Involvement of Free Radicals in Chemical Carcinogenesis

      • William A. Pryor

      Pages 1-9

   2. Autoxidation and Enzymatic Oxidation of Unsaturated Lipids

      • Ned A. Porter

      Pages 11-16

   3. Electron vs. H-Atom Transfer in Chemical Repair

      • Michael G. Simic, Edward P. L. Hunter, Slobodan V. Jovanovic

      Pages 17-24

   4. Radiation Induced Reactions of Glutathione with Oxygen and their Possible Role in Biological Systems

      • M. Tamba, G. Simone, M. Quintiliani

      Pages 25-32

   5. Potential Limitation to Hydrogen Atom Donation as a Mechanism of Repair in Chemical Models of Radiation Damage

      • J. A. Raleigh, A. F. Fuciarelli, C. R. Kulatunga

      Pages 33-39

   6. Mechanisms of Inactivation of Oxygen Species by Carotenoids

      • Norman I. Krinsky

      Pages 41-46

   7. Inhibition of Autoxidation by Vitamin E and Bilirubin

      • Mohammed Al-Sheikhly, Michael G. Simic

      Pages 47-50

3. Oxygen Species in Carcinogenesis

   1. The Role of Active Oxygen and the Metabolism of Arachidonic Acid in the Formation of Clastogenic Factor by Human Monocytes

      • Walter Kozumbo, Dominique Muehlematter, Takafumi Ochi, Peter Cerutti

      Pages 51-57

   2. Clastogenic Factors, A Link Between Chronic Inflammation and Carcinogenesis

      • Ingrid Emerit

      Pages 59-62

   3. Role of Eicosanoids in Tumor Cell-Platelet-Endothelial Cell Interactions

      • Bruce W. Steinert, Bonnie F. Sloane, David G. Menter, John D. Crissman, John D. Taylor, Kenneth V. Honn

      Pages 63-69

   4. The Involvement of Peroxyl Free Radicals in Tumor Initiation and Promotion

      • Lawrence J. Marnett

      Pages 71-80

   5. Amplification of Tissue Peroxides in Disease

      • William E. M. Lands, Robert B. Pendleton

      Pages 81-84

   6. Peroxisome Proliferation-Related Oxidative Stress and Hepato-Carcinogenesis

      • Janardan K. Reddy, M. Sambasiva Rao

      Pages 85-91

   7. Hydroxyl Free Radical Mediated Strand Breaks in PBR322 Plasmid DNA

      • E. Schneider, J. J. Watson, R. A. Floyd

      Pages 93-96

   8. Radiation-Like Modification of DNA and H2O2 Formation by Activated Human Polymorphonuclear Leukocytes (PMNs)

      • Krystyna Frenkel, Kazimierz Chrzan

      Pages 97-102

   9. Mitochondrial DNA Damage during Mitochondrial Lipid Peroxidation

      • Andrew M. Hruszkewycz

      Pages 103-108

   10. Mitigation of Singlet Oxygen (1ΔgO2) Damage in Biological Systems

       • Thomas A. Dahl, Philip E. Hartman, W. Robert Midden

       Pages 109-113

   11. Reactive Oxygen Species are Mutagenic to Mammalian Cells

       • Abraham W. Hsie

       Pages 115-119

4. Enzymatic Repair of DNA Damage

   1. The Expression of Bacterial DNA Alkylation Repair Enzymes in Mer- Human Cells

      • Leona Samson, Patrick Carroll, Bruce Derfler, William Rebeck

      Pages 121-127

This book is based on the invited and contributed papers presented at the 2nd International Conference on Anticarcinogenesis and Radiation Protection held at the National Bureau of Standards, Gaithersburg, Maryland, USA, on March 8-12, 1987. The conference documented developments that have taken place in areas that were addressed during the first conference in 1982. A number of new topics, such as biological response modifiers, were included because of their emerging relevance to anticarcinogenesis and radiation protection. The organization of the material in this book does not follow the conference program; rather, we have attempted to provide a different sequence for didactic reasons. The aim of the conference, which is reflected in this book, was to promote further development of mechanistic approaches to cancer prevention and treatment based on recent progress in molecular biology and free radical chemistry. At the basis of carcinogenesis lie changes in the dynamics of growth and differentiation of specific cell subpopulations in the target tissue. 'These changes are brought about by selective toxicity and modulation of gene expression that are induced by xenobiotic carcinogens and affected by physiological and genetic factors. The book deals with oxidative stress and molecular damage caused by radiation and chemical pro-oxidants and their role in carcinogenesis, and it discusses mechanisms of deregulation of the expression of oncogenes and other genes involved in carcinogenic initiation and promotion.

• cancer prevention
• carcinogenesis
• cell
• molecular biology
• prevention
• radiation protection

• Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

  Peter A. Cerutti

• Case Western Reserve University, Cleveland, USA

  Oddvar F. Nygaard

• National Bureau of Standards, Gaithersburg, USA

  Michael G. Simic

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