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Table of contents (17 chapters)
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Developments in Immuno-, Molecular, and Cell Biology: Implications for Clinical Stem Cell Transplantation
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Sources of Hematopoietic Stem Cells and Their Ex Vivo Expansion
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Reducing the Toxicity Associated with Hematopoietic Stem Cell Transplantation
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Clinical Applications: Continued Progress and New Frontiers
Keywords
About this book
Possible applications of stem cell transplantation continue to grow with the identification of alternative sources of stem cells and the potential to engineer and/orexpand the graft. Although the use of unrelated and mismatched donors continues to increase, the possibilities associated with umbilical cord blood transplantation are legion, especially if stem cells can be expanded ex vivo to provide grafts for full-sized adults. Using techniques in which contaminating malignant cells may be eliminated from autografts through positive selection, autologous transplantation may prove highly effective, especially when coupled with post-transplant immunotherapy. Some of these same methodologies have helped facilitate the use of autologous grafts for transplantation in patients with chronic myelogenous leukemia without allogeneic donors.
Advances in the supportive care of transplant patients, including the pretransplant identification of those at risk from pulmonary complications and the use of cytokines to speed engraftment, have reduced morbidity and mortality to such a degree that it is appropriate to consider high-dose therapy and stem cell reconstitution in patients with nonmalignant diseases. The impressive advances that have occurred in transplantation for thalassemia are described by pioneers in their area of investigation. The burgeoning field of transplantation for autoimmune disorders, including its immunobiologic basis and soon-to- be-realized clinical potential, is also summarized. Continued progress in the use of high-dose therapy with stem cell rescue for the treatment of pediatric tumors, which derives in part from improved supportive care, is detailed.
The sobering voice of the health care economists underscores the necessary limitations to our seemingly unbridled imagination. Cost- consciousness and financial know-how will need to be reflected in future study designs. Given the seemingly endless applications of our technology, strategies to insure its cost-effectiveness will be necessary. Continued financial support for laboratory investigation and for the clinical experiments they generate will be required if we are to go forward. Blood Stem Cell Transplantation lays the foundation for many of these future advances; it is incumbent upon us all to insure its realization.
Editors and Affiliations
Bibliographic Information
Book Title: Blood Stem Cell Transplantation
Editors: Jane N. Winter
Series Title: Cancer Treatment and Research
DOI: https://doi.org/10.1007/978-1-4615-6349-5
Publisher: Springer New York, NY
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eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 1997
Hardcover ISBN: 978-0-7923-4260-1Published: 31 March 1997
Softcover ISBN: 978-1-4613-7916-4Published: 08 October 2012
eBook ISBN: 978-1-4615-6349-5Published: 06 December 2012
Series ISSN: 0927-3042
Series E-ISSN: 2509-8497
Edition Number: 1
Number of Pages: XV, 416
Topics: Oncology, Surgical Oncology