Soft Tissue Sarcomas: Present Achievements and Future Prospects

1. Front Matter

   Pages i-xi

   PDF

2. Value of peer review of pathology in soft tissue sarcomas

   • Martin Harris, Ann L. Hartley

   Pages 1-8

3. Cytogenetics of soft tissue tumors

   • Jonathan A. Fletcher

   Pages 9-29

4. Molecular genetics of soft tissue sarcomas

   • Colin S. Cooper, Paul Cornes

   Pages 31-50

5. PET imaging in soft tissue sarcomas

   • Floro Miraldi, Lee P. Adler, Peter Faulhaber

   Pages 51-64

6. Metastasectomy for soft tissue sarcomas

   • Ugo Pastorino

   Pages 65-75

7. Post-treatment limb function in soft tissue sarcomas

   • Martin H. Robinson

   Pages 77-93

8. Benign and low-grade tumors of the soft tissues: Role for radiation therapy

   • Herman D. Suit, Ira J. Spiro, Matthew Spear

   Pages 95-105

9. Brachytherapy for soft tissue sarcomas

   • Phillip M. Devlin, Louis B. Harrison

   Pages 107-128

10. Three-dimensional planning and conformal radiotherapy

    • Clive Harmer, Margaret Bidmead

    Pages 129-141

11. Radiation-induced bone and soft tissue sarcomas: Clinical aspects and molecular biology

    • Ira J. Spiro, Herman D. Suit

    Pages 143-155

12. Chemotherapy for metastatic soft tissue sarcomas

    • William P. Steward

    Pages 157-172

13. Adjuvant chemotherapy of soft tissue sarcomas

    • Jaap Verweij, Herbert M. Pinedo

    Pages 173-187

14. Isolated limb perfusion with high-dose tumor necrosis factor-α for locally advanced extremity soft tissue sarcomas

    • A. M. M. Eggermont, H. Schraffordt Koops, J. M. Klausner, P. M. Schlag, B. B. R. Kroon, G. Ben-Ari et al.

    Pages 189-203

15. Soft tissue sarcomas in children

    • Alberto S. Pappo, Charles B. Pratt

    Pages 205-222

16. Back Matter

    Pages 223-232

    PDF

The previous volumes in this series on soft tissue sarcomas highlighted the importance of the multidisciplinary approach to treatment, and this focus is continued in the present volume. Proper diagnosis and staging remain the cornerstone of the treatment strategy. Sophisticated histopathology tech­ niques and growing consensus on grading systems have further increased the importance of the histopathologist in providing estimates of patient prognosis as well as in providing data for planning the treatment strategy. The use of cytogenetics in this field is rapidly increasing and might enable the distinction of subgroups in specific histological tumor types. Furthermore, molecular biological studies not only help reveal inherited predispositions and details in tumor oncogenesis, but they may also provide additional predictive factors for tumor behavior. Further data on treatment strategy will be provided by diag­ nostic imaging, and in this volume the value of PET imaging, a relatively new achievement, is highlighted. As far as the actual treatment is concerned, surgery still provides the major opportunity for cure. The addition of radiotherapy to surgery is of utmost importance in efforts to spare as much tissue as possible. The chapters on the planning of radiotherapy, brachytherapy, and the treatment of benign soft tissue lesions using radiotherapy are new contributions to this book. One of the potential late problems of radiotherapy is the occurrence of secondary soft tissue sarcomas, which is discussed in Chapter 10.

• brachytherapy
• cytogenetics
• genetics
• histopathology
• imaging
• metastasis
• metastatic disease
• molecular genetics
• pathology
• radiotherapy
• tumor

• Department of Medical Oncology, Rotterdam Cancer Institute, Rotterdam, The Netherlands

  J. Verweij

• Department of Medical Oncology, Free University Hospital, Amsterdam, The Netherlands

  H. M. Pinedo

• Department of Radiation Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA

  H. D. Suit

Policies and ethics