Analytical and Quantitative Cardiology

1. Front Matter

   Pages i-xvi

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2. Molecular Signalling

   1. Front Matter

      Pages 1-1

      PDF

   2. CA2+-Signaling in Cardiac Myocytes: Evidence from Evolutionary and Transgenic Models

      • Martin Morad, Yuichiro J. Suzuki

      Pages 3-12

   3. Diastolic Viscoelastic Properties of Rat Cardiac Muscle; Involvement of Ca2+

      • Bruno D. M. Y. Stuyvers, Masahito Miura, Henk E. D. J. ter Keurs

      Pages 13-28

   4. The Beta Subunit, Kvβ1.2, Acts as a Rapid Open Channel Blocker of NH₂-Terminal Deleted Kv1.4 α-Subunits

      • Randall L. Rasmusson, Shimin Wang, Robert C. Castellino, Michael J. Morales, Harold C. Strauss

      Pages 29-37

   5. Signal Transduction in Ischemic Preconditioning

      • James M. Downey, Michael V. Cohen

      Pages 39-55

   6. CA2+ Sparks within 200 nm of the Sarcolemma of Rat Ventricular Cells: Evidence from Total Internal Reflection Fluorescence Microscopy

      • Lars Cleemann, Giancarlo DiMassa, Martin Morad

      Pages 57-65

   7. Uncoupling of G-Protein Coupled Receptors in vivo: Insights from Transgenic Mice

      • Howard A. Rockman

      Pages 67-72

3. The Contractile Mechanism and Energetics

   1. Front Matter

      Pages 73-73

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   2. Molecular Control of Myocardial Mechanics and Energetics: The Chemo-Mechanical Conversion

      • Amir Landesberg

      Pages 75-87

   3. Myocardial Cell Energetics

      • Helmut Kammermeier

      Pages 89-96

   4. Human Heart Failure: Determinants of Ventricular Dysfunction

      • Norman R. Alpert, Louis A. Mulieri

      Pages 97-108

4. Cardiac Mechanics and Flow Dynamics

   1. Front Matter

      Pages 109-109

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   2. How Cardiac Contraction Affects the Coronary Vasculature

      • Nicolaas Westerhof, Pieter Sipkema, Martijn A. Vis

      Pages 111-121

   3. Dynamic Interaction between Myocardial Contraction and Coronary Flow

      • Rafael Beyar, Samuel Sideman

      Pages 123-137

   4. The Relations between Microvascular Structure and Oxygen Supply

      • Uri Dinnar

      Pages 139-151

5. Vascular Structure and Remodeling

   1. Front Matter

      Pages 153-153

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   2. Endothelial Gene Regulation by Laminar Shear Stress

      • Nitzan Resnick, Hava Yahav, Levon M. Khachigian, Tucker Collins, Keith R. Anderson, Forbes C. Dewey et al.

      Pages 155-164

   3. 3D Architecture of Myocardial Microcirculation in Intact Rat Heart: A Study with Micro-CT

      • Patricia E. Beighley, Paul J. Thomas, Steven M. Jorgensen, Erik L. Ritman

      Pages 165-175

   4. Vascular Imaging by Ultrasound: 3D Reconstruction of Flow Velocity Fields for Endothelial Shear Stress Calculation

      • Dan R. Adam, Pablo Burstein

      Pages 177-185

The tenth Henry Goldberg Workshop is an excellent occasion to recall our goals and celebrate some of our humble achievements. Vision and love of our fellow man are combined here to: 1) Foster interdisciplinary interaction between leading world scientists and clinical cardiologists so as to identify missing knowledge and catalyze new research ideas; 2) relate basic microscale, molecular and subcellular phenomena to the global clinically manifested cardiac performance; 3) apply conceptual modelling and quantitative analysis to better explore, describe, and understand cardiac physiology; 4) interpret available clinical data and design new revealing experiments; and 5) enhance international cooperation in the endless search for the secrets of life and their implication on cardiac pathophysiology. The first Goldberg Workshop, held in Haifa, in 1984, explored the interaction of mechanics, electrical activation, perfusion and metabolism, emphasizing imaging in the clinical environment. The second Workshop, in 1985, discussed the same parameters with a slant towards the control aspects. The third Goldberg Workshop, held in the USA at Rutgers University, in 1986, highlighted the transformation of the microscale activation phenomena to macro scale activity and performance, relating electrophysiology, energy metabolism and cardiac mechanics. The fourth Goldberg Workshop continued the effort to elucidate the various parameters affecting cardiac performance, with emphasis on the ischemic heart. The fifth Workshop concentrated on the effect of the inhomogeneity of the cardiac muscle on its performance. The sixth Workshop highlighted new imaging techniques which allow insight into the local and global cardiac performance.

• endothelium
• genes
• metabolism
• pathophysiology
• physiology
• tissue
• viscoelastic properties

• The Julius Silver Institute, Technion–Israel Institute of Technology, Haifa, Israel

  Samuel Sideman, Rafael Beyar

Policies and ethics