Advances in Ocular Toxicology

1. Front Matter

   Pages i-xv

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2. Welcome and Opening of Congress

   • Keith Green

   Pages 1-2

3. Cytochrome P450 and Arachidonic Acid Metabolism in the Corneal Epithelium

   • Michal Laniado Schwartzman

   Pages 3-20

4. The Effects of 12(R)Hete and Its Metabolite 8(R)HHDTre on Corneal Endothelial Function

   • Henry F. Edelhauser, K. Keven Williams, Glenn P. Holley, Wendell D. Woods

   Pages 21-26

5. Protein-Thiol Mixed Disulfides and Thioltransferase in the Lens

   • Marjorie F. Lou

   Pages 27-46

6. Corneal Lesions in Beagle Dogs Given Oral 5-Ethynyluracil Followed by 5-Fluorouracil

   • Robert L. Peiffer Jr., J. E. Dillberger

   Pages 47-53

7. Corneal Damage Following Continuous Infusion in Rats

   • Olivier Loget, Camélia Nanuel, Jean-François Le Bigot, Roy Forster

   Pages 55-62

8. Ultraviolet Light-Induced Damage in Rabbit Corneal Epithelial Cells in Vitro

   • Mercedes Palmero, Alfonso Blanco, Juan L. Bellot, Nuria Alcoriza, Irene Perez, Alfredo Orts

   Pages 63-72

9. The Effects of AD Libitum (AL) Overfeeding and Moderate Dietary Restriction (DR) on the Incidence of Spontaneous Corneal Dystrophy in Control Sprague-Dawley (SD) Rats

   • M.-F. Hubert, Ph. Laroque, G. Durand-Cavagna, P. Delort, K. P. Keenan

   Pages 73-80

10. Barotoxic Effects on Morphology and Viability of Trabecular Cells

    • Brenda J. Tripathi, Ramesh C. Tripathi, Junping Li, Ying Qian, W. Kosnosky, K. V. Chalam

    Pages 81-86

11. Topical Fluorescein Application Can Induce Iritis and Glaucoma

    • Clayton Bryan, Junping Li, Brenda J. Tripathi, K. V. Chalam, Vytautas Al Pakalnis, Ramesh C. Tripathi

    Pages 87-91

12. Ocular Toxicity of Sodium Diethylthiocarbamate, DDTC, in the Beagle Dog

    • Stephen Bistner, Tom Palmer, Lydia Dickrell

    Pages 93-95

13. Do Therapeutic Doses of Ethambutol Cause Optic Nerve Toxicity?

    • Dinesh Talwar, Randeep Guleria, Anant Pai, S. P. Garg

    Pages 97-101

14. Testing of Ocular Viscoelastics by Injection into the Rabbit Vitreous

    • P. J. Upman, K. A. Herkowski, M. J. Shepherd

    Pages 103-106

15. Effects of Antiviral Agents on Retinal Function in Vertebrate Retina

    • C. Lüke, P. Walter, K. U. Bartz-Schmidt, R. Brunner, K. Heimann, W. Sickel

    Pages 107-112

16. Experimental Implantation of Devices for Electrical Retinal Stimulation In Rabbits

    • Peter Walter, Peter Szurman, Ralf Krott, Uta Baum, Karl-Ullrich Bartz-Schmidt, Klaus Heimann

    Pages 113-120

17. Nitric Oxide in Ocular Inflammation

    • J. B. Allen, M. C. McGahan, L. N. Fleisher, G. J. Jaffe, T. Keng, C. T. Privalle

    Pages 121-131

18. Role of Nitric Oxide in Vascular Dysfunction Associated with Ocular Diseases

    • Ronald G. Tilton

    Pages 133-149

19. Effects of the Inhibition of Nitric Oxide Synthase and Lipoxygenase on the Development of Endotoxin-Induced Uveitis

    • Juan L. Bellot, Nuria Alcoriza, Mercedes Palmero, Alfonso Blanco, Rafael Espí, Claude Hariton et al.

    Pages 151-158

20. Evaluation of Two Rabbit Ocular Implantation Models Using Polymethylmethacrylate Intraocular Lenses

    • John N. Norton, Robert B. Hackett, Robert J. Munger

    Pages 159-167

This volume represents the proceedings of the Fifth Congress of the International Society of Ocular Toxicology (ISOT), which was held at the Grove Park Inn and Resort in Asheville, North Carolina, October 13-17, 1996. We are delighted to present this volume to the ophthalmic community, especially those with a significant interest in ocular toxicol­ ogy. The Fifth Congress was developed around themes relating to ocular drug metabolism, the ocular pathophysiological effects of nitric oxide, government issues relating to the use of alternative methods for toxicity testing, and a workshop that encompassed comparisons of both in vitro versus in vivo models as well as different animal models. The outcome of this congress, embodied in this volume, is a contribution to the methodologies currently employed or under development and to various drug or physical effects on different ocular tissues. While the focus of this proceedings is on ocular effects of drugs or other materials, many of the contributions deal with topics that have a much broader interest. The workshop concerning the use of different model systems and the choice of the best animal model for drug testing covers a wide range of interests that ex­ tends far beyond specific ocular effects. This is especially true in the area of alternative methods and in the choice of the best animal model for examination of different disease entities.

• cytochrome P450
• development
• drug
• eye
• inflammation
• metabolism
• research
• tissue
• toxicity
• toxicity testing
• toxicology
• uveitis

• Medical College of Georgia, Augusta

  Keith Green, David S. Hull

• Emory University, Atlanta

  Henry F. Edelhauser

• Alcon Laboratories, Inc., Fort Worth

  Robert B. Hackett

• Morehouse School of Medicine, Atlanta

  David E. Potter

• University of South Carolina School of Medicine, Columbia

  Ramesh C. Tripathi

Policies and ethics