Cholesterol

1. Front Matter

   Pages i-xxviii

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2. Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway

   • Simon M. Jackson, Johan Ericsson, Peter A. Edwards

   Pages 1-21

3. Coordinate Regulation of Cholesterol 7α-Hydroxylase and HMG-CoA Reductase in the Liver

   • Ingemar Björkhem, Erik Lund, Mats Rudling

   Pages 23-55

4. Polyprenyl Diphosphate Synthases

   • Kyozo Ogura, Tanetoshi Koyama, Hiroshi Sagami

   Pages 57-87

5. Antifungal Sterol Biosynthesis Inhibitors

   • De-an Guo, Anil T. Mangla, Wen Zhou, Monica Lopez, Zhonghua Jia, S. Derrek Nichols et al.

   Pages 89-116

6. The Smith—Lemli—Opitz Syndrome: A Potentially Fatal Birth Defect Caused by a Block in the Last Enzymatic Step in Cholesterol Biosynthesis

   • G. S. Tint, Ashok K. Batta, Guorong Xu, Sarah Shefer, Akira Honda, Mira Irons et al.

   Pages 117-144

7. Has Nature Designed the Cholesterol Side Chain for Optimal Interaction with Phospholipids?

   • Robert Bittman

   Pages 145-171

8. Cholesterol and Myelin

   • G. Jackson Snipes, Ueli Suter

   Pages 173-204

9. Regulation of Mitochondrial Cholesterol Metabolism

   • Federico Martínez, Jerome F. Strauss III

   Pages 205-234

10. Lipoproteins and Cellular Cholesterol Homeostasis

    • William J. Johnson, Michael C. Phillips, George H. Rothblat

    Pages 235-276

11. Cholesterol-Sphingomyelin Interactions in Cells—Effects on Lipid Metabolism

    • J. Peter Slotte

    Pages 277-293

12. Mechanisms and (Patho)Physiological Significance of Biliary Cholesterol Secretion

    • Folkert Kuipers, Ronald P. J. Oude Elferink, Henkjan J. Verkade, Albert K. Groen

    Pages 295-318

13. Cholesterol Deposition in Atherosclerotic Lesions

    • Howard S. Kruth

    Pages 319-362

14. Cholesterol Metabolism and Tumor Cell Proliferation

    • Peter S. Coleman, Li-Chuan Chen, Laura Sepp-Lorenzino

    Pages 363-435

15. Biological Implications of the Niemann-Pick C Mutation

    • Peter G. Pentchev, E. Joan Blanchette-Mackie, Laura Liscum

    Pages 437-451

16. Sitosterolemia

    • Gerald Salen, Sarah Shefer, Lien Nguyen, Gene C. Ness, G. S. Tint, Ashok K. Batta

    Pages 453-476

17. Cholesterol Cytochemistry in Cell Biology and Disease

    • Nicholas J. Severs

    Pages 477-505

18. Approaches for the Design of Novel Anti-Atherogenic Compounds

    • Erik A. L. Biessen, Leo A. J. M. Sliedregt, Theo J. C. Van Berkel

    Pages 507-539

19. Back Matter

    Pages 541-548

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Experts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broad range of topics, including key steps in the cholesterol biosynthetic pathway, and the role of cholesterol in cancer, atherosclerosis, and diseases of the nervous system. The book's comprehensive coverage also includes the pathological consequences and potential therapies for various disease states, and the development of new anti-atherogenic drugs.

• Lipid
• development
• metabolism
• nervous system
• proteins
• reductase

`An excellent and up-to-date overview...A useful volume for libraries, investigators, or graduate students.'
Inform, September 1998

• Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, USA

  Robert Bittman

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