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Advances in Swine in Biomedical Research

Volume 2

  • Book
  • © 1996

Overview

Editors:
  1. Mike E. Tumbleson

    1. University of Illinois, Urbana, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Lawrence B. Schook

    1. University of Minnesota, St. Paul, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (37 chapters)

  1. Front Matter

    Pages i-xviii
    Download chapter PDF

  2. Methods and Techniques

    1. Swine Research Breeds, Methods, and Biomedical Models

      • Michael P. Murtaugh, Nancy A. Monteiro-Riviere, Linda Panepinto
      Pages 423-424

    2. The Pig as a Model for Cutaneous Pharmacology and Toxicology Research

      • Nancy A. Monteiro-Riviere, Jim Riviere
      Pages 425-458

    3. An in vitro Pig Skin Model for Predicting Human Skin Penetration and Irritation Potential

      • William G. Reifenrath, Barbara W. Kemppainen, Winifred G. Palmer
      Pages 459-474

    4. Swine Liver Usage in Extracorporeal Detoxification

      • Vyacheslav E. Ryabinin
      Pages 475-483

    5. Pig Behavior and Biomedical Research

      • Harold W. Gonyou
      Pages 485-490

    6. Current Status of in vitro Production of Porcine Embryos

      • Hiroaki Funahashi, Billy N. Day
      Pages 491-502

    7. Reproductive Physiology in Chinese Meishan Pigs

      • Brett R. White, JoElla Barnes, Matthew B. Wheeler
      Pages 503-521

    8. Selection for Extremes in Serum FSH Concentrations Results in Reduced Testis Size and Fertility in Meishan and White Composite Boars

      • Donald D. Lunstra, J. Joe Ford, Thomas H. Wise
      Pages 523-531

    9. Reproductive Characteristics in Sinclair Miniature Swine

      • Guy F. Bouchard, Ronald M. McLaughlin, Mark R. Ellersieck, Gary F. Krause, Craig Franklin, Chada S. Reddy
      Pages 533-542

    10. A Comparison of Physiological and Biochemical Parameters in Fully Conscious Hormel-Hanford and Yucatan Strains of Miniature Pig

      • George J. Ikeda, Theodore C. Michel, Dennis W. Gaines, Vira L. Olivito, Philip P. Sapienza, Leonard Friedman et al.
      Pages 543-555

    11. Biochemical Indices of Stress Associated with Short-Term Restraint in Hormel and Yucatan Miniature Swine

      • Leonard Friedman, Linda Panepinto, Dennis W. Gaines, Ruey Chi, Robert C. Braunberg, James Terris
      Pages 557-570

    12. The Minipig as a Model for the Study of Aging in Humans

      • Sam J. Bhathena, Elliott Berlin, Wesley A. Johnson
      Pages 571-579

    13. Aging and Miniature Swine Heart and Liver Plasma Membranes

      • Elliott Berlin, Melanie A. Banks, Sam J. Bhathena, Renee C. Peters, Wesley A. Johnson
      Pages 581-593

    14. Comparing Porcine Models of Coronary Restenosis

      • Robert N. Willette, Hong Zhang, Calvert Louden, Robert K. Jackson
      Pages 595-606

    15. Sinclair Miniature Swine Melanoma as a Model for Evaluating Novel Lymphography Contrast Agents

      • David K. Johnson, Erik R. Wisner, Stephen M. Griffey, Adele R. Vessey, Patrick J. Haley
      Pages 607-612

    16. The Yucatan Miniature Pig Model of Ventricular Septal Defect

      • M. Michael Swindle, Robert P. Thompson, Alison C. Smith, George B. Keech, Blase A. Carabello, Wolfgang Radtke et al.
      Pages 613-620

    17. An External Thoracic Duct Venous Shunt to Allow for Long Term Collection of Lymph and Blood in the Conscious Pig

      • H. Vince Mendenhall, Christopher Horvath, Marek Piechowiak, Lisa Johnson, Kim Bayer
      Pages 621-627

    18. Pregnant Yucatan Miniature Swine as a Model for Investigating Fetal Drug Therapy

      • Donald B. Wiest, M. Michael Swindle, Sandra S. Garner, Alison C. Smith, Paul C. Gillette
      Pages 629-635

    19. A Swine Model for Determining the Bioavailability of Lead from Contaminated Media

      • Stan W. Casteel, Ross P. Cowart, Christopher P. Weis, Gerry M. Henningsen, Eva Hoffman, William J. Brattin et al.
      Pages 637-646
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Keywords

About this book

Similarities in structure and function between pigs and human beings include size, feeding patterns, digestive physiology, dietary habits, kidney structure and function, pulmo­ nary vascular bed structure, coronary artery distribution, propensity to obesity, respiratory rates, tidal volumes and social behaviors. Since the pig is an omnivore, it provides an adaptable model to evaluate chronic and acute exposures to xenobiotics such as alcohoL caffeine, tobacco, food additives and environmental pollutants. Swine have been used successfully as models to evaluate alcoholism, diabetes, absorption, digestion, total paren­ teral nutrition, organ transplantation, atherosclerosis, exercise, hypertension. hemorrhagic hypotension, melanoma, gingivitis, obstructive and reflux nephropathy. osteochondrosis. dermal healing and septic shock. A severe and worsening shortage of organs and tissues for transplantation in patients with severe organ failure has encouraged the consideration of inter species or xenotransplan­ tation. In developing programs toward this end, the pig generally is viewed as the preferred donor because of its size, physiology and availability. The pig harbors relatively few diseases which could be transmitted inadvertently to human patients. The ability to genetically modify swine to ameliorate the consequences of the human immune response offers a further significant advantage. Another important consideration for an animal model is that basic biologic back­ ground information be available for investigators to design future prospective studies.

Editors and Affiliations

  • University of Illinois, Urbana, USA

    Mike E. Tumbleson

  • University of Minnesota, St. Paul, USA

    Lawrence B. Schook

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