Neutrons in Biology

1. Front Matter

   Pages i-x

   PDF

2. Neutrons in Biology: A Perspective

   1. Neutrons in Biology

      • R. B. Knott, B. P. Schoenborn

      Pages 1-15

3. Plenary Lecture

   1. Neutron Anatomy

      • G. E. Bacon

      Pages 17-27

4. Neutron Sources

   1. Neutron Scattering Facilities

      • D. L. Price

      Pages 29-29

   2. The NIST NBSR and Cold Neutron Research Facility

      • J. J. Rush

      Pages 31-31

   3. Neutron Scattering Instrumentation for Biology at Spallation Neutron Sources

      • Roger Pynn

      Pages 33-33

   4. The Potential for Biological Structure Determination with Pulsed Neutrons

      • C. C. Wilson

      Pages 35-55

5. Neutron Instrumentations

   1. High Precision Thermal Neutron Detectors

      • V. Radeka, N. A. Schaknowski, G. C. Smith, B. Yu

      Pages 57-67

   2. Neutron Scattering in Australia

      • Robert B. Knott

      Pages 69-93

   3. Structural Biology Facilities at Brookhaven National Laboratory’s High Flux Beam Reactor

      • Z. R. Korszun, A. M. Saxena, D. K. Schneider

      Pages 95-103

   4. Neutron Instrumentation for Biology

      • S. A. Mason

      Pages 105-105

   5. Neutron Scattering and Diffraction Instrument for Structural Study on Biology in Japan

      • Nobuo Niimura

      Pages 107-113

   6. Small-Angle Neutron Scattering Instrument of Institute for Solid State Physics, the University of Tokyo (SANS-U) and its Application to Biology

      • Yuji Ito, Masayuki Imai, Shiro Takahashi

      Pages 115-126

6. Small Angle Scattering

   1. Neutron Scattering Studies on Chromatin Higher-Order Structure

      • Vito Graziano, Sue Ellen Gerchman, Dieter K. Schneider, Venki Ramakrishnan

      Pages 127-136

   2. The Structure of the Muscle Protein Complex 4Ca2+·Troponin C·Troponin I

      • Glenn Allen Olah, Jill Trewhella

      Pages 137-147

   3. Structural Model of the 50S Subunit of E. Coli Ribosomes from Solution Scattering

      • D. I. Svergun, M. H. J. Koch, J. Skov Pedersen, I. N. Serdyuk

      Pages 149-174

   4. Probing Self Assembly in Biological Mixed Colloids by Sans, Deuteration, and Molecular Manipulation

      • Rex P. Hjelm, P. Thiyagarajan, A. Hoffman, C. Schteingart, Hayat Alkan-Onyuksel

      Pages 175-190

7. Membrane Structures and Dynamics

   1. Neutron Diffraction Studies of Amphipathic Helices in Phospholipid Bilayers

      • J. P. Bradshaw, K. C. Duff, P. J. Gilchrist, A. M. Saxena

      Pages 191-202

   2. Fluid Bilayer Structure Determination

      • S. H. White, M. C. Wiener

      Pages 203-204

   3. Neutron Reflectivity Studies of Single Lipid Bilayers Supported on Planar Substrates

      • S. Krueger, B. W. Koenig, W. J. Orts, N. F. Berk, C. F. Majkrzak, K. Gawrisch

      Pages 205-213

This compendium presents some of the major applications of neutron scattering techniques to problems in biology. It is a record of the papers presented at the Neutrons in Biology Conference, the third in an occasional series held to highlight progress in the field and to provide a focus for future direction. The strength ofthe neutron scattering technique remains principally in the manipula­ tion of scattering density through hydrogen and deuterium atoms. The development ofad­ vanced detectors, innovative instrument and beamline components, and sophisticated data acquisition systems through the 1970s and early 1980s provided a sound foundation for the technique. With continued development, some of the exotic and expensive equipment has become affordable by the medium-sized facilities, thereby broadening the user base considerably. Despite problems with the major neutron sources in the late 1980s and early 1990s, some spectacular results have been achieved. Whilst the high and medium flux beam reac­ tors will continue to make a major impact in the field, the results from the first experi­ ments, and the planned developments on spallation neutron sources, clearly indicate that the technique has enormous potential.

• DNA
• Lipid
• base
• development
• protein

• Los Alamos National Laboratory, Los Alamos, USA

  Benno P. Schoenborn

• Australian Nuclear Science and Technology Organisation, Menai, Australia

  Robert B. Knott

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