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Triple Helix Forming Oligonucleotides

  • Book
  • © 1999

Overview

Editors:
  1. Claude Malvy

    1. CNRS, France

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    You can also search for this editor in PubMed   Google Scholar

  2. Annick Harel-Bellan

    1. CNRS, France

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    You can also search for this editor in PubMed   Google Scholar

  3. Linda L. Pritchard

    1. CNRS, France

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Perspectives in Antisense Science (DARE, volume 2)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xv
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  2. Background and Structural Aspects

    1. Front Matter

      Pages 1-1
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    2. The Antigene Strategy: Progress and Perspectives in Selective Gene Silencing

      • Claude Hélène
      Pages 3-16

    3. Triple-Helix Structure. The Triple-Helix-Forming Oligonucleotide

      • Horea Porumb
      Pages 17-31

    4. Thermodynamic State Diagrams of Oligonucleotide Triple Helices

      • G. Eric Plum, K. J. Breslauer
      Pages 33-47

    5. Imaging of Triplexes by Electron and Scanning Force Microscopy

      • Dmitry Cherny
      Pages 49-62

    6. Chemical Modifications of Triple Helix Forming Oligonucleotides

      • Ulysse Asseline
      Pages 63-73

    7. Triple Helix Formation with Modified Oligonucleotides

      • Sergei M. Gryaznov
      Pages 75-85

    8. Oligonucleotides as Artificial DNases

      • Valentina Zarytova, Asya Levina
      Pages 87-97

  3. The Biology of Triple Helices

    1. Front Matter

      Pages 99-99
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    2. Potential Mechanisms of Action

      • L. James Maher
      Pages 101-115

    3. Oligonucleotide Uptake and Delivery in Tissue Culture Cells

      • Scot W. Ebbinghaus, Nadarajah Vigneswaran, Charles M. Mayfield, David T. Curiel, Donald M. Miller
      Pages 117-127

    4. Triple-Stranded Complexes as Antigene Molecules: Transcription Inhibition Ex Vivo

      • Carine Giovannangeli
      Pages 129-143

    5. Gene-Targeting Triple Helix Forming Purine Oligonucleotides

      • Fedor Svinarchuk, Claude Malvy
      Pages 145-157

    6. DNA Triple Helix as a Tool to Regulate Cytokine Gene Expression

      • Marina Kochetkova, Mary Frances Shannon
      Pages 159-166

    7. Genome Modification by Triplex-Forming Oligonucleotides

      • Karen M. Vasquez, Peter M. Glazer
      Pages 167-179

    8. Psoralen-Coupled Oligonucleotides: In Vivo Binding and Repair

      • François-Xavier Barre, Linda L. Pritchard, Annick Harel-Bellan
      Pages 181-192

    9. Structure and Biology of H DNA

      • Sergei M. Mirkin
      Pages 193-222

    10. Triplex-Binding Proteins

      • Anne-Laure Guieysse, Daniele Praseuth
      Pages 223-231

    11. RNA and Triple Helices

      • Kyonggeun Yoon, Jörg Jendis, Karin Moelling
      Pages 233-242
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Keywords

About this book

Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.

Editors and Affiliations

  • CNRS, France

    Claude Malvy, Annick Harel-Bellan, Linda L. Pritchard

Bibliographic Information

  • Book Title: Triple Helix Forming Oligonucleotides

  • Editors: Claude Malvy, Annick Harel-Bellan, Linda L. Pritchard

  • Series Title: Perspectives in Antisense Science

  • DOI: https://doi.org/10.1007/978-1-4615-5177-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • Hardcover ISBN: 978-0-7923-8418-2Published: 28 February 1999

  • Softcover ISBN: 978-1-4613-7358-2Published: 30 October 2012

  • eBook ISBN: 978-1-4615-5177-5Published: 06 December 2012

  • Series ISSN: 1566-0389

  • Edition Number: 1

  • Number of Pages: XV, 297

  • Topics: Cell Biology, Biochemistry, general, Pharmacy, Human Genetics

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