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Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity

Molecular Approaches to Determine Mechanisms of Toxicity

  • Book
  • © 1999

Overview

Authors:
  1. Maria E. Ariza

    1. Arizona Cancer Center, University of Arizona, USA

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  2. Gautam N. Bijur

    1. Behavioral Neurobiology, University of Alabama at Birmingham, UK

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    You can also search for this author in PubMed   Google Scholar

  3. Marshall V. Williams

    1. Department of Medical Microbiology & Immunology, The Ohio State University, USA

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Environmental Metal Pollutants: Sources and Determinants of Toxicity

    • Maria E. Ariza, Gautam N. Bijur, Marshall V. Williams
    Pages 1-16

  3. Toxicological Profiles

    • Maria E. Ariza, Gautam N. Bijur, Marshall V. Williams
    Pages 17-52

  4. Metals, Metalloids and Oxidative Stress

    • Maria E. Ariza, Gautam N. Bijur, Marshall V. Williams
    Pages 53-95

  5. Metals, Metalloids and Genetic Stability

    • Maria E. Ariza, Gautam N. Bijur, Marshall V. Williams
    Pages 97-129

  6. Cell Cycle and Apoptosis

    • Maria E. Ariza, Gautam N. Bijur, Marshall V. Williams
    Pages 131-169

  7. Effects of Environmental Metal and Metalloid Pollutants on Human Health

    • Maria E. Ariza, Gautam N. Bijur, Marshall V. Williams
    Pages 171-181

  8. Back Matter

    Pages 183-189
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Keywords

About this book

Humans are exposed daily to low concentrations of metals that are released into the environment by both natural and industrial processes. Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity: Molecular Approaches to Determine Mechanisms of Toxicity examines concerns about the acute and/or chronic exposure of humans to concentrations of these metals that are below the threshold levels established by various federal regulatory agencies. Some of these metals are accumulated in various tissues and over time this may result in the accumulation of a significant body burden. This could increase the risk of developing a variety of diseases later in life, at a time when thresholds for such effects may already be reduced by the processes of aging. Such possibilities could only further compromise the quality of life in the elderly population and could contribute to the rising cost of health care in this country.
Studies that have been conducted to determine the possible risks associated with exposure to relatively non-toxic concentrations of environmental metals have been hampered by a lack of appropriate models and a lack of funding. It has also been difficult for researchers to demonstrate a correlation between the exposure of humans or animals to low concentrations of environmental pollutants and disease. This book examines recent technological advances in the areas of molecular biology, biochemistry, and computer-enhanced image analyses that provide researchers with the tools to begin elucidating the genotoxic effects of environmental metal pollutants and the mechanisms by which these metals cause DNA damage.
Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity: Molecular Approaches to Determine Mechanisms of Toxicity presents data that demonstrate that certain environmental metal pollutants are genotoxic. The authors describe the role of reactive oxygen intermediates in causing the DNA damage induced by environmental metal pollutants and discuss their possible role in human disease.

Authors and Affiliations

  • Arizona Cancer Center, University of Arizona, USA

    Maria E. Ariza

  • Behavioral Neurobiology, University of Alabama at Birmingham, UK

    Gautam N. Bijur

  • Department of Medical Microbiology & Immunology, The Ohio State University, USA

    Marshall V. Williams

Bibliographic Information

  • Book Title: Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity

  • Book Subtitle: Molecular Approaches to Determine Mechanisms of Toxicity

  • Authors: Maria E. Ariza, Gautam N. Bijur, Marshall V. Williams

  • DOI: https://doi.org/10.1007/978-1-4615-5153-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • Hardcover ISBN: 978-0-7923-8448-9Published: 31 March 1999

  • Softcover ISBN: 978-1-4613-7346-9Published: 09 October 2012

  • eBook ISBN: 978-1-4615-5153-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 189

  • Topics: Public Health, Ecotoxicology, Environmental Management, Veterinary Medicine/Veterinary Science, Environmental Engineering/Biotechnology

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