Osteoporosis: Genetics, Prevention and Treatment

1. Front Matter

   Pages i-xi

   PDF

2. Osteoporosis: Understanding and Managing a Growing Health Care Problem

   1. Osteoporosis: Understanding and Managing a Growing Health Care Problem

      • John S. Adams, Barbara P. Lukert

      Pages 1-4

3. Genetics

   1. Front Matter

      Pages 5-5

      PDF

   2. Molecular Genetics of Skeletal Morphogenesis

      • Vicki Rosen, Laura Gamer

      Pages 7-23

   3. Genetics of Osteoporosis

      • John S. Adams

      Pages 25-32

   4. Genetic Strategies in Preclinical Osteoporosis Research

      • Robert F. Klein

      Pages 33-55

   5. Interdependence of Genetic and Epigenetic Factors in Determining Bone Strength

      • Janet Rubin, Clinton T. Rubin

      Pages 57-72

4. Diagnosis, Prevention, and Treatment

   1. Front Matter

      Pages 73-73

      PDF

   2. Quantitation of Bone Mineral Density in the Growing Skeleton: Methods and Meaning

      • Vicente Gilsanz

      Pages 75-88

   3. Prevention of Osteoporosis: Strategies for Optimizing Peak Bone Mass

      • Susan H. Allen

      Pages 89-119

   4. Skeletal Consequences Of Physical Activity

      • Robert Marcus

      Pages 121-133

   5. Postmenopausal Osteoporosis

      • Patrick M. Doran, Sundeep Khosla

      Pages 135-154

   6. Individualizing Osteoporosis Therapy

      • Stuart L. Silverman

      Pages 155-165

5. Osteoporotic Syndromes of Emerging Impact

   1. Front Matter

      Pages 167-167

      PDF

   2. Fall Prevention and Physical Therapy

      • Sally Rigler, Stephanie Studenski

      Pages 169-182

   3. Diagnosis and Treatment of Male Osteoporosis

      • Eric S. Orwoll

      Pages 183-204

   4. Diagnosis and Treatment of Renal Osteodystrophy

      • Dean T. Yamaguchi, Arnold J. Felsenfeld

      Pages 205-232

   5. Diagnosis and Treatment of Osteoporosis Associated with Immunosuppressive Therapy

      • Maria A. Rodino, Elizabeth Shane

      Pages 233-246

   6. Cancer and Bone Disease

      • Mark S. Nanes, Louisa Titus

      Pages 247-274

   7. Common Diseases Which May Complicate the Osteoporosis Phenotype

      • Michael Davies

      Pages 275-291

Modern society is altering the lifestyle and longevity of its members much more quickly than evolutionary adaptation to these changes can take place. The problem of calcium deficiency in the population is compounded by the growing percentage of aged individuals with relatively fragile, less massive skeletons. Current-day civilizations are much more effective in prolonging human life in a state of relative debility than even a few decades ago. This reality is unlikely to change and mandates that we develop strategies to prevent aging-related diseases like osteoporosis before they become manifest.
Osteoporosis: Genetics, Prevention and Treatment places emphasis on the (1) genetic predisposition, (2) early recognition and (3) prevention of osteoporosis. The intent is not to move the practitioner's attention away from intervention therapy of osteoporosis, but rather to expand their view of this disease as one beginning at birth and one in which susceptibility is manifest at the conclusion of adolescence, not at menopause. The book concludes with an informed view of the future in terms of the recognition, prevention and management of osteoporosis.

• bone
• calcium
• genetics
• hormone
• hormones
• molecular genetics
• osteoporosis
• physical therapy
• prevention
• diabetes

• Cedars-Sinai Medical Center, Los Angeles, USA

  John S. Adams

• University of Kansas Medical School, Kansas City, USA

  Barbara P. Lukert

Policies and ethics