Clinical Applications of Cytokines and Growth Factors

1. Front Matter

   Pages i-xii

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2. Biology of Hematopoietic and Lymphopoietic Cytokines

   1. Front Matter

      Pages 1-1

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   2. Cytokines, Growth Factors and Hematopoiesis

      • Grover C. Bagby Jr., Michael C. Heinrich

      Pages 2-55

   3. The Interaction of Cytokines with Stem Cell and Stromal Cell Physiology

      • Paul J. Simmons, David N. Haylock, Jean-Pierre Levesque, Andrew C. W. Zannettino

      Pages 56-73

   4. The Interaction of Cytokines with T cell and Natural Killer Cell Physiology

      • Richard A. Carter, Edmund K. Waller

      Pages 74-89

   5. Improving on Nature by Re-Engineering Hematopoietic Growth Factors

      • Yiqing Feng, John McKearn

      Pages 90-116

3. Management of Neutropenia and Neutropenic Fever

   1. Front Matter

      Pages 117-117

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   2. The Influence of Colony-Stimulating Factors on Neutrophil Production, Distribution, and Function

      • J. Milton Gaviria, W. Conrad Liles, David C. Dale

      Pages 118-136

   3. Evidence-Based Use of Hematopoietic Cytokines in Clinical Oncology

      • George D. Demetri

      Pages 137-149

   4. Economic, Public Health, and Policy Implications of Hematopoietic Growth Factors, High-dose Chemotherapy, and Stem Cell Rescue

      • Charles L. Bennett, Tammy J. Stinson

      Pages 150-158

   5. Outpatient Management of Neutropenic Fever: Antibiotics, Growth Factors or Both?

      • Edward B Rubenstein, Linda S. Elting, Charlotte C. Sun, Kenneth V. I. Rolston

      Pages 159-177

   6. The Use of Hematopoietic Growth Factors for Recruitment of Leukocytes for Transfusion

      • David B. Jendiroba, Benjamin Lichtiger, Emil J. Freireich

      Pages 178-185

4. Management of Anemia

   1. Front Matter

      Pages 186-186

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   2. Pathophysiology of the Anemia of Malignancy

      • John W. Adamson

      Pages 187-197

   3. The Use of Recombinant Erythropoietin in the Treatment and Prevention of Cancer and Chemotherapy-related Anemia

      • Jerry L. Spivak

      Pages 198-216

5. Management of Thrombocytopenia

   1. Front Matter

      Pages 217-217

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   2. Regulation of Human Megakaryocytopoiesis

      • Ronald Hoffman, Michael W. Long

      Pages 218-236

   3. The Effects of Multilineage Cytokines on Platelet Recovery

      • Ravi Vij, John DiPersio

      Pages 237-268

   4. Clinical Studies of Thrombopoietin

      • Russell L. Basser

      Pages 269-277

6. The Role of Cytokines to Enhance Cancer Chemotherapy

   1. Front Matter

      Pages 278-278

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The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity. The activity of the hematopoietic system is staggering: daily, a normal adult produces approximately 2.5 billion erythrocytes, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight. This production is adjusted in a timely fashion to changes in actual needs and can vary from nearly none to many times the normal rate depending on needs which vary from day to day, or even minute to minute. In response to a variety of stimuli, the cellular components of the blood are promptly increased or decreased in production to maintain appropriate numbers to optimally protect the host from hypoxia, infection, and hemorrhage. How does this all happen and happen without over or under responding? There has been extraordinary growth in our understanding ofhematopoiesis over the last two decades. Occupying center stage is the pluripotent stern cell and its progeny. Hematopoietic stern cells have been characterized by their capacity for self renewal and their ability to proliferate and differentiate along multiple lineages. Few in number, the stern cell gives rise to all circulating neutrophils, erythrocytes, lymphoid cells, and platelets. In hematopoietic transplantation, the stern cell is capable of restoring long-term hematopoiesis in a lethally irradiated host.

• anemia
• blood
• chemotherapy
• cytokine
• cytokines
• growth
• growth factor
• transplantation

• Bone Marrow Transplant Program, Division of Hematology/Oncology, University of Florida College of Medicine, Shands Hospital, Gainesville, USA

  John R. Wingard

• Department of Adult Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA

  George D. Demetri

Policies and ethics