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Molecular and Cellular Mechanisms of Neuronal Plasticity

Basic and Clinical Implications

  • Book
  • © 1998

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 446)

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Table of contents (13 chapters)

Keywords

About this book

Numerous studies have proven the biological basis of memory formation and have begun to identify the biochemical traces and cellular circuits that are formed by experience, and which participate int the storage of information in the brain, its retention for long durations, and its retrieval upon demand. Cells in the nervous system have the capability of undergoing extremely long-lasting alterations in response to hormonal, pharmacological, and environmental stimulations. The mechanisms underlying this neuronal plasticity are activated by experiential inputs and operate in the process of learning and the formation of memories in the brain. This volume presents research areas which have not been highlighted in the past. In addition to studies on the involement of functional proteins in neuronal adaptation, this volume presents recent developments on the critical roles of bioactive lipids and nucleotides in these processes. In addition to the widely studied role of second messengers, a review of studies on extracellular phosphorylation systems operating on the surface of brain neurons is presented.The first section of the volume presents studies of basic mechanisms operating in a wide range of adaptive processes. The second section presents recent advances in investigations that have demonstrated the clinical implications of this research. These include: state of the art use of transgenic models in studies of molecular and cellular mechanisms implicated in familial Alzheimer's disease and Amyotrophic Lateral Sclerosis; studies of specific proteins implicated in Alzheimer's disease, including an adapter that binds to the beta-amyloid precurser protein (beta-APP) and the microtubular protein Tau and its membrane-bound counterpart. The advantages of using cell culture models for elucidating the causes of neuronal degeneration and for identifying mechanisms of neuroprotection are also presented among the chapters in the section on clinical implications.

Editors and Affiliations

  • The College of Staten Island of The City University of New York, USA

    Yigal H. Ehrlich

  • The CSI/IBR Center for Developmental Neuroscience Staten Island, New York, USA

    Yigal H. Ehrlich

  • The City University Graduate School, New York, USA

    Yigal H. Ehrlich

Bibliographic Information

  • Book Title: Molecular and Cellular Mechanisms of Neuronal Plasticity

  • Book Subtitle: Basic and Clinical Implications

  • Editors: Yigal H. Ehrlich

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-4869-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1998

  • Hardcover ISBN: 978-0-306-46040-1Published: 31 March 1999

  • Softcover ISBN: 978-1-4613-7209-7Published: 27 September 2012

  • eBook ISBN: 978-1-4615-4869-0Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 229

  • Topics: Neurosciences, Neurology, Human Genetics, Anatomy

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