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Lipoxygenases and their Metabolites

Biological Functions

  • Book
  • © 1999

Overview

Editors:
  1. Santosh Nigam

    1. Free University of Berlin, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Cecil R. Pace-Asciak

    1. Hospital for Sick Children, University of Toronto, Toronto, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 447)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Introductory Remarks

    • Tankred Schewe, Cecil R. Pace-Asciak, Santosh Nigam
    Pages 1-4

  3. Mammalian 15-Lipoxygenases

    • Hartmut Kühn, Sabine Borngräber
    Pages 5-28

  4. Molecular Cloning of a Second Human 15S-Lipoxygenase and its Murine Homologue, an 8S-Lipoxygenase

    • Alan R. Brash, Mitsuo Jisaka, William E. Boeglin, Min S. Chang
    Pages 29-36

  5. Arachidonate 12-Lipoxygenase Isozymes

    • Shozo Yamamoto, Hiroshi Suzuki, Michihiro Nakamura, Kazunori Ishimura
    Pages 37-44

  6. Expression of Leukocyte-Type 12-Lipoxygenase and Reticulocyte-Type 15-Lipoxygenase in Rabbits

    • Bernd-Joachim Thiele, Mario Berger, Kristin Schwarz, Sabine Borngräber, Hartmut Kühn, Antje Ostareck-Lederer et al.
    Pages 45-61

  7. Lipoxygenase Gene Disruption Studies

    • Eric N. Johnson, Duxin Sun, Xin-Sheng Chen, Colin D. Funk
    Pages 63-73

  8. The Release of Polyunsaturated Fatty Acids and Their Lipoxygenation in the Brain

    • Hee-Yong Kim, Lisa Edsall, Martha Garcia, Hongjian Zhang
    Pages 75-85

  9. Biological Relevance of the 12-Lipoxygenase Pathway for Platelet and Lymphocyte Functions

    • M. Lagarde, C. Calzada, A. Zakaroff, N. Meskini, A. F. Prigent, E. Véricel
    Pages 87-93

  10. Effect of 15-Hete on the 5-Lipoxygenase Pathway in Neutrophils

    • Tankred Schewe, Karen Petrich, Peter Ludwig, Hartmut Kühn, Santosh Nigam
    Pages 95-105

  11. Adenosine

    • Eric Krump, Pierre Borgeat
    Pages 107-115

  12. Pharmacological Aspects of 5-Lipoxygenase Inhibition

    • R. Müller-Peddinghaus
    Pages 117-121

  13. The Hepoxilins

    • Cecil R. Pace-Asciak, Denis Reynaud, Peter Demin, Santosh Nigam
    Pages 123-132

  14. Aspirin-Triggered 15-Epi-Lipoxin A4 and Stable Analogs of Lipoxin A4 are Potent Inhibitors of Acute Inflammation

    • Charles N. Serhan, Tomoko Takano, Jane F. Maddox
    Pages 133-149

  15. Modulation of LTB4 Receptor in T-Lymphocytes by Lipoxin A4 (LXA4) and Its Role in Delayed-Type Hypersensitivity

    • King-Teh Lin, Henry P. Godfrey, Eric G. Spokas, Frank F. Sun, Patrick Y-K Wong
    Pages 151-163

  16. Receptors for Cysteinyl-Leukotrienes in Human Cells

    • Simonetta Nicosia, Valérie Capra, Maria Rosa Accomazzo, Daniela Ragnuni, Saula Ravasi, Alessia Caiani et al.
    Pages 165-170

  17. Cysteinyl-Leukotrienes and the Human Lung

    • Isabelle Gorenne, Carlos Labat, Xavier Norel, Jean-Pierre Gascard, Charles Brink
    Pages 171-179

  18. 12(S)-HETE in Cancer Metastasis

    • Keqin Tang, Kenneth V. Honn
    Pages 181-191

  19. A 12(s)-Hete Receptor in Lewis Lung Carcinoma Cells

    • Helena Herbertsson, Tobias Kühme, Sven Hammarström
    Pages 193-198

  20. Fatty Acids, Eicosanoids, and Hypolipidemic Agents Regulate Gene Expression Through Direct Binding to Peroxisome Proliferator-Activated Receptors

    • Walter Wahli, Pallavi R. Devchand, Annemieke I. Jpenberg, Béatrice Desvergne
    Pages 199-209
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Keywords

About this book

This book is a result of the First Conference on Lipoxygenases, held at Malta, May 17th-2l st, 1997. The goal was very ambitious: having lipoxygenases as a focus for distant and diverse experimental approaches, we brought together scientists to discuss and build a consensus on the biological role of lipoxygenases. Although still fuzzy in many details, the Malta conference has shown that a unifying view on lipoxygenases is finally taking shape, and that the experimental evidence of links and conjugations among events OCCUf­ ing from cell membranes to intracellular compartments and the nucleus is becoming in­ creasingly convincing. The editors are deeply grateful to Hospital for Sick Children, Toronto, Free Univer­ sity Berlin, NOAA Sea Grant College Program (U. S. A. ), Schering, Berlin (F. R. G. ), and Cayman Chemicals, Ann Arbor, Michigan (U. S. A. ), for their generous financial support, which was crucial in making the conference a scientific success. The conference received financial support from a number of additional sponsors, and we express our gratitude to Abbott Labs (U. S. A. ), Air Malta (Malta), Ass. Int. Cancer Res. (U. K. ), Biometra (F. R. G. ), Bayer AG (F. R. G. ), IBL Co. (F. R. G. ), Merck Frosst (Canada), Perkin Elmer (F. R. G. ), Scotia Pharmaceuticals (Canada), Searle (U. S. A. ), SPI Chemicals (France), and TOPCRO (Austria).

Editors and Affiliations

  • Free University of Berlin, Berlin, Germany

    Santosh Nigam

  • Hospital for Sick Children, University of Toronto, Toronto, Canada

    Cecil R. Pace-Asciak

Bibliographic Information

  • Book Title: Lipoxygenases and their Metabolites

  • Book Subtitle: Biological Functions

  • Editors: Santosh Nigam, Cecil R. Pace-Asciak

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-4861-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1999

  • Hardcover ISBN: 978-0-306-46044-9Published: 31 January 1999

  • Softcover ISBN: 978-1-4613-7205-9Published: 23 October 2012

  • eBook ISBN: 978-1-4615-4861-4Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: IX, 230

  • Topics: Biochemistry, general, Pharmacology/Toxicology

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