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Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

  • Book
  • © 1999

Overview

Editors:
  1. Emel Arinç

    1. Middle East Technical University, Ankara, Turkey

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    You can also search for this editor in PubMed   Google Scholar

  2. John B. Schenkman

    1. University of Connecticut Health Center, Farmington, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Ernest Hodgson

    1. North Carolina State University, Raleigh, USA

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Part of the book series: NATO Science Series A: (NSSA, volume 303)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. The Fate of Xenobiotics in the Body

    • John B. Schenkman
    Pages 1-20

  3. Protein-Protein Interactions in the P450 Monooxygenase System

    • John B. Schenkman, Ingela Jansson, Gary Davis, Paul P. Tamburini, Zhongqing Lu, Zhe Zhang et al.
    Pages 21-39

  4. Structures of Mitochondrial P450 System Proteins

    • Israel Hanukoglu
    Pages 41-54

  5. Biochemical Aspects of Flavin-Containing Monooxygenases (FMOs)

    • Ernest Hodgson, Nathan J. Cherrington, Richard M. Philpot, Randy L. Rose
    Pages 55-70

  6. Expression and Regulation of Flavin-Containing Monooxygenases

    • Richard M. Philpot, Christine P. Biagini, Geraldine T. Carver, Lila H. Overby, M. Keith Wyatt, Kiyoshi Itagaki
    Pages 71-79

  7. Correlations between in Vivo and in Vitro Studies in Human Drug Metabolism

    • Michel Eichelbaum
    Pages 81-90

  8. Pharmacogenetics Polymorphisms in Xenobiotic Metabolism

    • Frank J. Gonzalez
    Pages 91-110

  9. Clinical Aspects of Polymorphic Drug Metabolism in Humans

    • Michel Eichelbaum
    Pages 111-126

  10. Genetic Polymorphisms of Cytochromes P450 1A1 and 2E1 and of Glutathione S-Transferase Ml and Cancer Susceptibility in the Human

    • Minro Watanabe
    Pages 127-143

  11. Cytochrome P450 Isoforms

    • Ernest Hodgson, R. Michael Roe, Joyce E. Goldstein, Siming Liu, Scott C. Coleman, Randy L. Rose
    Pages 145-155

  12. Inhibitors of CYP51 As Antifungal Agents and Resistance to Azole Antifungals

    • Steven L. Kelly, David C. Lamb, Diane E. Kelly
    Pages 157-172

  13. The Role of Oxidative Drug Metabolizing Enzymes in Liver and Lung Specific Toxicity

    • Richard M. Philpot
    Pages 173-182

  14. Importance of Drug Metabolism in Drug Discovery and Development

    • Rodolfo Gasser
    Pages 183-193

  15. Aflatoxin Biotransformation and Toxicology

    • David L. Eaton
    Pages 195-209

  16. Role of Individual Enzymes in the Control of Genotoxic Metabolites

    • Franz Oesch, Michael Arand
    Pages 211-220

  17. Enhancement of the Mutagenicity of Ethylene Oxide and Several Directly Acting Mutagens by Human Erythrocytes and its Reduction by Xenobiotic Interaction

    • Jan G. Hengstler, Jochen Walz, Rani Kübel, Tri Truong, Jürgen Fuchs, Albrecht Seidel et al.
    Pages 221-246

  18. Cytochrome P4501A1 (CYP 1A1) and Associated MFO Activities in Fish as an Indicator of Pollution with Special Reference to Izmir Bay

    • Emel Arinç, Alaattin Sen
    Pages 247-257

  19. CYP 1A Concentrations as an Indicator of Exposure of Fish to Pulp-Mill Effluents

    • R. F. Addison, J. Y. Wilson
    Pages 259-270

  20. The Biochemistry And Physiology of Prostacyclin- and Thromboxane-Synthase

    • Volker Ullrich
    Pages 271-282
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Keywords

Editors and Affiliations

  • Middle East Technical University, Ankara, Turkey

    Emel Arinç

  • University of Connecticut Health Center, Farmington, USA

    John B. Schenkman

  • North Carolina State University, Raleigh, USA

    Ernest Hodgson

Bibliographic Information

  • Book Title: Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

  • Editors: Emel Arinç, John B. Schenkman, Ernest Hodgson

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4615-4855-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • Hardcover ISBN: 978-0-306-46048-7Published: 31 January 1999

  • Softcover ISBN: 978-1-4613-7202-8Published: 08 October 2012

  • eBook ISBN: 978-1-4615-4855-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 294

  • Topics: Biochemistry, general, Pharmacology/Toxicology

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