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Enzyme-Prodrug Strategies for Cancer Therapy

  • Book
  • © 1999

Overview

Editors:
  1. Roger G. Melton

    1. Enzacta Ltd., Porton Down, Wiltshire, UK

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  2. Richard J. Knox

    1. Imperial College School of Medicine, Charing Cross Campus, London, UK

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Introduction

    • Richard J. Knox, Roger G. Melton
    Pages 1-9

  3. Prodrugs in Cancer Chemotherapy

    • Tom Connors
    Pages 11-37

  4. Factors Influencing Tumor-Selective Localization of Antibody Conjugates

    • M. A. Sims, Roger G. Melton
    Pages 39-96

  5. Enzymes and Prodrugs Used for ADEPT

    • Richard J. Knox
    Pages 97-131

  6. The Design and Synthesis of Prodrugs for Antibody-Directed Enzyme Prodrug Therapy (ADEPT)

    • P. J. Burke
    Pages 133-154

  7. Preparation and Purification of Antibody-Enzyme Conjugates for Therapeutic Applications

    • Roger G. Melton
    Pages 155-178

  8. Phage Technology for Producing Antibody-Enzyme Fusion Proteins

    • K. A. Chester, Roger G. Melton, R. E. Hawkins
    Pages 179-198

  9. Early Clinical Studies with ADEPT

    • K. D. Bagshawe, M. Napier
    Pages 199-207

  10. Gene-Directed Enzyme Prodrug Therapy (GDEPT) of Cancer

    • Richard J. Knox
    Pages 209-243

  11. Back Matter

    Pages 245-257
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Keywords

About this book

Antibody-directed enzyme prodrug therapy (ADEPT) directly addresses the major problem in cancer chemotherapy-its lack of selectivity. Antibody delivery combined with the amplification provided by the enzymatic activation of prodrugs enables selection to be made between tumour and normal tissue. ADEPT offers a novel field of opportunities in the therapy of systemic cancer and may be a major advance for the treatment of solid tumours.
This book is the first to describe ADEPT in detail. Each chapter reviews an aspect of the immunology, enzymology, biochemistry, chemistry, and cancer chemotherapy which have been integrated into the ADEPT concept. An additional chapter describes the related approach of gene-directed enzyme prodrug therapy (GDEPT). This latter approach is still in its infancy but ADEPT has entered the clinic. The initial clinical studies with ADEPT are included and discussed in detail.

Editors and Affiliations

  • Enzacta Ltd., Porton Down, Wiltshire, UK

    Roger G. Melton

  • Imperial College School of Medicine, Charing Cross Campus, London, UK

    Richard J. Knox

Bibliographic Information

  • Book Title: Enzyme-Prodrug Strategies for Cancer Therapy

  • Editors: Roger G. Melton, Richard J. Knox

  • DOI: https://doi.org/10.1007/978-1-4615-4823-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • Hardcover ISBN: 978-0-306-45895-8Published: 31 January 1999

  • Softcover ISBN: 978-1-4613-7186-1Published: 06 October 2012

  • eBook ISBN: 978-1-4615-4823-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 257

  • Topics: Internal Medicine, Oncology, Immunology, Biochemistry, general, Biomedical Engineering and Bioengineering

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