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Oxidative Stress and Vascular Disease

  • Book
  • © 2000

Overview

Editors:
  1. John F. Keaney

    1. Boston University School of Medicine, Boston, USA

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 224)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvii
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  2. General Concepts

    1. Front Matter

      Pages 1-1
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    2. What is Oxidative Stress?

      • Helmut Sies
      Pages 1-8

    3. Sources of Vascular Oxidative Stress

      • Jay W. Heinecke
      Pages 9-25

    4. Antioxidant Defenses in the Vascular Wall

      • Roland Stocker
      Pages 27-47

  3. Atherosclerosis

    1. Front Matter

      Pages 49-49
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    2. The Oxidative Modification Hypothesis of Atherogenesis

      • Sotirios Tsimikas, Joseph L. Witztum
      Pages 49-74

    3. Mechanisms of LDL Oxidation

      • Mark R. McCall, Balz Frei
      Pages 75-98

    4. Oxidized Phospholipids as Mediators of Vascular Disease

      • Sean Davies, Thomas McIntyre, Stephen Prescott, Guy Zimmerman
      Pages 99-118

    5. MM-LDL and Atherogenesis — A Major Role for Phospholipid Oxidation Products

      • Norbert Leitinger, Judith A. Berliner
      Pages 119-134

    6. Oxidation-Sensitive Transcription and Gene Expression in Atherosclerosis

      • Charles Kunsch, Russell M. Medford
      Pages 135-154

    7. Atherosclerosis, Oxidative Stress, and Endothelial Function

      • John F. Keaney Jr.
      Pages 155-181

    8. Oxidants and Antioxidants in Platelet Function

      • Jane E. Freedman
      Pages 183-194

    9. Antioxidants and Atherosclerosis: Animal Studies

      • John F. Keaney Jr.
      Pages 195-211

    10. Human Studies of Antioxidants and Vascular Function

      • Elizabeth S. Biegelsen, Joseph A. Vita
      Pages 213-243

    11. Antioxidants and Cardiovascular Disease

      • J. Michael Gaziano
      Pages 245-258

  4. Diabetes

    1. Front Matter

      Pages 259-259
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    2. Glycation and Glycoxidation in Diabetic Vascular Disease

      • Suzanne R. Thorpe, Timothy J. Lyons, John W. Baynes
      Pages 259-285

    3. Advanced Glycosylation Endproducts and Diabetic Vascular Disease

      • Richard Bucala
      Pages 287-303

    4. Hyperglycemia and Diabetes — Induced Vascular Dysfunction: Role of Oxidative Stress

      • Galen M. Pieper
      Pages 305-322
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Keywords

About this book

One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all­ cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.

Editors and Affiliations

  • Boston University School of Medicine, Boston, USA

    John F. Keaney

Bibliographic Information

  • Book Title: Oxidative Stress and Vascular Disease

  • Editors: John F. Keaney

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4615-4649-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2000

  • Hardcover ISBN: 978-0-7923-8678-0Published: 31 December 1999

  • Softcover ISBN: 978-1-4613-7103-8Published: 12 October 2012

  • eBook ISBN: 978-1-4615-4649-8Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XVII, 373

  • Topics: Cardiology

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