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Pain and Neuroimmune Interactions

  • Book
  • © 2000

Overview

Editors:
  1. Nayef E. Saadé

    1. American University of Beirut, Beirut, Lebanon

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  2. A. Vania Apkarian

    1. SUNY Health Science Center, Syracuse, USA

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  3. Suhayl J. Jabbur

    1. American University of Beirut, Beirut, Lebanon

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-x
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  2. Nociceptors and Proinflammatory Mediators

    1. Front Matter

      Pages 1-1
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    2. Persistent Hyperalgesia and Cytokines

      • Sergio H. Ferreira, Daniela Sachs, Fernando Q. Cunha, B. B. Lorenzetti
      Pages 3-8

    3. Nociceptor Excitation by Sensitization: A Novel Hypothesis, Its Cellular and Molecular Background

      • Peter W. Reeh, Gabor Pethö
      Pages 9-19

    4. Tachykinins in Visceral Pain and Hyperalgesia

      • Fernando Cervero, Jennifer M. A. Laird
      Pages 21-29

    5. Bradykinin, Cytokines and Inflammatory Hyperalgesia

      • Stephen Poole, Fernando de Queiroz Cunha, Sergio Henriques Ferreira
      Pages 31-54

  3. Hyperalgesia: Peripheral and Central Mechanisms

    1. Front Matter

      Pages 55-55
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    2. Neurotransmitter and Inflammatory Correlates in Experimental Neuropathy: Modulation by Electric Spinal Cord Stimulation

      • Bengt Linderoth, Jian-Guo Cui, Vadym Yakhnitsa, T.-J. Sten Shi, Carl-Olav Stiller, William T. O’Connor et al.
      Pages 57-68

    3. Diffuse Noxious Inhibitory Controls and Arthritis in the Rat

      • Nicolas Danziger, Daniel Le Bars, Didier Bouhassira
      Pages 69-78

    4. NSAIDs and Some Safe Strategies of Their Use: Spinal C-Fos Protein Studies in Carrageenan Model of Inflammatory Nociceptive Processes

      • Jaroslava Buritova, Jean-Marie Besson
      Pages 79-98

    5. The Role of Dorsal Root Reflexes in Neurogenic Inflammation and Pain

      • William D. Willis, J. Wu, Qing Lin
      Pages 99-110

    6. Pain and Neurogenic Inflammation: A Neural Substrate for Neuroendocrine-Immune Interactions

      • Nayef E. SaadĂ©, Cynthia A. Massaad, Salim A. Kanaan, Bared Safieh-Garabedian, Suhayl J. Jabbur, Samir F. Atweh
      Pages 111-123

  4. Pain and Central Neuroimmune Mechanisms

    1. Front Matter

      Pages 125-125
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    2. Thymic Peptides: Transmitters Between the Neuroendocrine and the Immune System

      • Mireille Dardenne, Bared Safieh-Garabedian, Jean-Marie Pleau
      Pages 127-137

    3. Thymulin and Inflammatory Pain: A Possible Substrate for Pge-2 Dependent Neuroimmune Loop

      • Bared Safieh-Garabedian, Salim A. Kanaan, Suhayl J. Jabbur, Samir F. Atweh, Nayef E. SaadĂ©
      Pages 139-147

    4. The Role of Peripheral and Brain-Borne Cytokines in Immune-Neuro-Endocrine Interactions

      • Hugo O. Besedovsky, Fernando Pitossi, Detlev Balschun, Horst Schneider, Adriana del Rey
      Pages 149-155

    5. Interleukin-1 Receptors and Ligands in the Nervous System

      • France Haour, Eleni Dicou
      Pages 157-169

    6. Biphasic Modulation of Pain by Hypothalamic Cytokines

      • T. Hori, T. Oka, M. Hosoi, M. Abe, K. Oka
      Pages 171-189

  5. Pain Consciousness and Limbic Mechanisms

    1. Front Matter

      Pages 191-191
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    2. In Search of Pain Consciousness or Pain and the Metaphysics of a Porsche 911

      • A. Vania Apkarian
      Pages 193-208
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Keywords

About this book

For those of us involved in research on the neural mechanisms that relate tissue damage to pain. it is becoming more evident that the sensation of pain and suffering could be considered as part of a mechanism that involves not only sizeable areas in the brain but also simultaneous activations of the immune and the endocrine systems as well. A consensus is growing among specialists in the field that pain involves the sharing of molecular mechanisms between the nervous, immune and endocrine systems that can interact at peripheral and, ultimately, central levels. Furthermore, chronic pain could then be looked upon as a corollary of the imbalance in the cross talk between these systems, which could lead to new treatment strategies. The aim of this book is not to deal with acute pain that serves as an alarm signal, but to attempt to explain the molecular mechanisms of chronic pains considered as a multifactorial syndrome or disease.

Editors and Affiliations

  • American University of Beirut, Beirut, Lebanon

    Nayef E. Saadé, Suhayl J. Jabbur

  • SUNY Health Science Center, Syracuse, USA

    A. Vania Apkarian

Bibliographic Information

  • Book Title: Pain and Neuroimmune Interactions

  • Editors: Nayef E. SaadĂ©, A. Vania Apkarian, Suhayl J. Jabbur

  • DOI: https://doi.org/10.1007/978-1-4615-4225-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2000

  • Hardcover ISBN: 978-0-306-46371-6Published: 30 April 2000

  • Softcover ISBN: 978-1-4613-6897-7Published: 01 March 2013

  • eBook ISBN: 978-1-4615-4225-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 244

  • Topics: Neurology, Pain Medicine, Biological and Medical Physics, Biophysics, Neurosciences

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