Anticarcinogenesis and Radiation Protection 2

1. Front Matter

   Pages i-xv

   PDF

2. Introductory Papers

   1. Cancer - Facts, Dilemmas and Mysteries

      • D. T. Kanazir

      Pages 1-12

   2. Environmental Causes of Cancer

      • Arthur C. Upton

      Pages 13-20

   3. The Evolution of Mutation Rates and Its Implications for Antimutagenesis

      • John W. Drake

      Pages 21-24

   4. Phenotypic Complementation of Cells from Human Hereditary Diseases with Defects in Cellular Responses to DNA Damage, by Single Human Chromosomes

      • Karla A. Henning, Clare Lambert, Roger A. Schultz, Errol C. Friedberg

      Pages 25-31

   5. Secondary Tumors

      • I. Spuzic, R. Tomin, M. Djordjevic

      Pages 33-37

   6. Strategies for the Prevention of Treatment-Induced Secondary Cancer

      • Hans P. Rutz, Rene O. Mirimanoff, John B. Little

      Pages 39-45

3. Molecular Biology

   1. The Expression of Bacterial DNA Repair Genes in Eukaryotic Cells and Vice Versa

      • Jin Chen, G. William Rebeck, Bruce Derfler, Leona Samson

      Pages 47-56

   2. Molecular Basis of Mutagenesis in Escherichia Coli K12 Deficient for DNA Polymerase I: Special Role of the Gtcg Sequence

      • Dragutin J. Savic, Mila Jankovic, Tatjana Kostic, Barry W. Glickman

      Pages 57-60

   3. Oxidative Mutagenesis by the Glutathione-Gamma-Glutamyl Transpeptidase System: Mechanism and Possible Relevance to Hepatocarcinogenesis

      • Avishay A. Stark, Dennis A. Pagano, Errol Zeiger

      Pages 61-71

   4. The Significance of Thymidine Kinase in Determining Resistance to Mutagenesis in Friend Mouse Leukemia Cells

      • P. Gerald McKenna, Yvonne A. Wilkinson, Valerie J. McKelvey

      Pages 73-77

   5. Single-Strand DNA Shuttle Vectors for Analyzing DNA-Damage Processing

      • Catherine Madzac, Alain Sarasin

      Pages 79-84

   6. Janus Neutron Irradiation of a Mouse Cell Line Containing a Shuttle Vector Plasmid

      • Biserka Nagy, David J. Grdina, Charles R. Ashman

      Pages 85-92

   7. Analysis of Constitutive and TCDD-Inducible Expression of Genes in the [Ah] Battery

      • Vesna Rapic, Daniel W. Nebert

      Pages 93-98

   8. Molecular Analysis of Tumorigenesis in Drosophila

      • Bernard Mechler

      Pages 99-106

   9. Tumor Suppressor Genes and the Age-Dependence of Cancer Incidence

      • Alfred G. Knudson Jr.

      Pages 107-109

   10. Expression and Regional Induction of c-fos Gene in the Central Nervous System After Brain Injury

       • Sabera Ruzdijic, Selma Kanazir, Mirjana Stojiljkovic, Ljubisav Rakic

       Pages 111-115

   11. Molecular Genetics of Oncogene Activation and Gene Loss in Carcinogen-Induced Animal Tumours

       • C. J. Kemp, R. Bremner, A. Balmain

       Pages 117-122

   12. Phorbol Ester Tumor Promoters and the Anti-Tumor-Promoter Dexamethasone Share a Molecular Target: Modulation of the Transcription Factor Ap-1 by a Novel Type of Interaction

       • Peter Herrlich, Carsten Jonat, Helmut Ponta, Hans Jobst Rahmsdorf

       Pages 123-127

   13. Transformation of Human Fibroblasts by N-RAS Oncogene

       • Lucja Fiszer-Maliszewska, Anne R. Kinsella

       Pages 129-134

The dramatic decrease in the incidence of stomach cancer in industrialized countries during the past 50 years, which is yet to be fully explained, and the observation that carcinogenesis in laboratory animals can be inhibited by antioxidants, retinoids, and caloric restriction, among other influences, challenge us to press on in the search for practical means to prevent cancer. It is in relation to this goal that the studies summarized in this book have special significance. This book is based on the invited and contributed papers presented at the Third Internationai Conference on Anticarcinogenesis and Radiation Protection, held on October 15-21, 1989, in Dubrovnik, Yugoslavia. They cover a broad range of investigations into the mechanisms and inhibition of carcinogenesis. In keeping with recent advances in our understanding of the importance of oncogenes and tumor-suppressor genes in carcinogenesis, many of the reports focus on mutations and related changes at the level of DNA. At the same time, however, other reports deal with nutritional, immunological, endocrinological, and epidemiological aspects. In all, the various reports address carcinogenesis and its inhibition at virtually every level of biological organization. Included in this compendium are timely reviews of diverse and promising research strategies for cancer prevention, as pursued by investigators in different parts of the world. The Organizers of the Conference are grateful to the many scientists who have contributed to the volume, as well as to the sponsors of the Conference, without whose generous support this book would not have been possible.

• DNA
• cancer prevention
• carcinogenesis
• hormones
• mutagen
• prevention
• radiation protection

• Case Western Reserve University, Cleveland, USA

  Oddvar F. Nygaard

• New York University Medical Center, New York, USA

  Arthur C. Upton

Policies and ethics